| # | Title | Journal | Year | Citations |
|---|
| 1 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,038 |
| 2 | Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial | Lancet, The | 2005 | 3,840 |
| 3 | Occlusal Caries: Biological Approach for Its Diagnosis and Management | Caries Research | 2016 | 1,469 |
| 4 | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 | Nature Genetics | 2011 | 1,201 |
| 5 | Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells | Stem Cells and Development | 2012 | 693 |
| 6 | Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study | Lancet, The | 2016 | 607 |
| 7 | Flavonoids as Anticancer Agents | Nutrients | 2020 | 605 |
| 8 | HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials | Lancet, The | 2015 | 562 |
| 9 | European Society of Cardiology Heart Failure Long‐Term Registry (ESC‐HF‐LT): 1‐year follow‐up outcomes and differences across regions | European Journal of Heart Failure | 2016 | 538 |
| 10 | The cost of headache disorders in Europe: the Eurolight project | European Journal of Neurology | 2012 | 537 |
| 11 | Are hospitalized or ambulatory patients with heart failure treated in accordance with European Society of Cardiology guidelines? Evidence from 12 440 patients of the ESC Heart Failure Long‐Term Registry | European Journal of Heart Failure | 2013 | 533 |
| 12 | Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data | BMJ, The | 2014 | 528 |
| 13 | Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data | Lancet Respiratory Medicine,the | 2014 | 527 |
| 14 | Preventing problematic internet use during the COVID-19 pandemic: Consensus guidance | Comprehensive Psychiatry | 2020 | 522 |
| 15 | Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies | Diabetologia | 2008 | 496 |
| 16 | Managing Carious Lesions | Advances in Dental Research | 2016 | 493 |
| 17 | European Hernia Society guidelines on the closure of abdominal wall incisions | Hernia: the Journal of Hernias and Abdominal Wall Surgery | 2015 | 460 |
| 18 | Validation of the Edinburgh Depression Scale during pregnancy | Journal of Psychosomatic Research | 2011 | 443 |
| 19 | Effects of Thyroxine as Compared with Thyroxine plus Triiodothyronine in Patients with Hypothyroidism | New England Journal of Medicine | 1999 | 440 |
| 20 | ERS guidelines on the diagnosis and treatment of chronic cough in adults and children | European Respiratory Journal | 2020 | 426 |
| 21 | Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study | European Heart Journal | 2019 | 421 |
| 22 | Trends in childhood type 1 diabetes incidence in Europe during 1989–2008: evidence of non-uniformity over time in rates of increase | Diabetologia | 2012 | 387 |
| 23 | The Role of Catechins in Cellular Responses to Oxidative Stress | Molecules | 2018 | 358 |
| 24 | International Nosocomial Infection Control Consortium (INICC) report, data summary for 2003-2008, issued June 2009 | American Journal of Infection Control | 2010 | 355 |
| 25 | Morphology, distribution, and variability of the epicardiac neural ganglionated subplexuses in the human heart | The Anatomical Record | 2000 | 354 |
| 26 | Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus | Gastroenterology | 2010 | 345 |
| 27 | Guidelines for the pharmacological treatment of anxiety disorders, obsessive–compulsive disorder and posttraumatic stress disorder in primary care | International Journal of Psychiatry in Clinical Practice | 2012 | 327 |
| 28 | Trends and cyclical variation in the incidence of childhood type 1 diabetes in 26 European centres in the 25 year period 1989–2013: a multicentre prospective registration study | Diabetologia | 2019 | 327 |
| 29 | Ten-Year Follow-up of a Prospective, Randomized Clinical Study of Mosaic Osteochondral Autologous Transplantation Versus Microfracture for the Treatment of Osteochondral Defects in the Knee Joint of Athletes | American Journal of Sports Medicine | 2012 | 314 |
| 30 | Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses | Lancet, The | 2019 | 305 |
| 31 | PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study | Lancet Diabetes and Endocrinology,the | 2017 | 298 |
| 32 | Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus | Arthritis Research and Therapy | 2009 | 297 |
| 33 | Expert opinion on the cough hypersensitivity syndrome in respiratory medicine | European Respiratory Journal | 2014 | 294 |
| 34 | Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer | Nature Genetics | 2014 | 294 |
| 35 | Theory of planned behavior approach to understand the green purchasing behavior in the EU: A cross-cultural study | Ecological Economics | 2016 | 293 |
| 36 | International consensus conference on stool banking for faecal microbiota transplantation in clinical practice | Gut | 2019 | 290 |
| 37 | RADIANCE: A Randomized Controlled Study of Ranibizumab in Patients with Choroidal Neovascularization Secondary to Pathologic Myopia | Ophthalmology | 2014 | 274 |
| 38 | The Persistent Exclusion of Older Patients From Ongoing Clinical Trials Regarding Heart Failure | Archives of Internal Medicine | 2011 | 272 |
| 39 | Determinants of cardiovascular disease and other non-communicable diseases in Central and Eastern Europe: Rationale and design of the HAPIEE study | BMC Public Health | 2006 | 269 |
| 40 | Prevention and control of dental caries and periodontal diseases at individual and population level: consensus report of group 3 of joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases | Journal of Clinical Periodontology | 2017 | 252 |
| 41 | Effects of ß-glucans on the immune system | Medicina (Lithuania) | 2007 | 248 |
| 42 | Managing Carious Lesions: Consensus Recommendations on Terminology | Advances in Dental Research | 2016 | 246 |
| 43 | Efficacy and safety of CT-P13 (biosimilar infliximab) in patients with rheumatoid arthritis: comparison between switching from reference infliximab to CT-P13 and continuing CT-P13 in the PLANETRA extension study | Annals of the Rheumatic Diseases | 2017 | 246 |
| 44 | Efficacy of Ursodeoxycholic Acid in Treating Intrahepatic Cholestasis of Pregnancy: A Meta-analysis | Gastroenterology | 2012 | 237 |
| 45 | Type D personality, mental distress, social support and health-related quality of life in coronary artery disease patients with heart failure: a longitudinal observational study | Health and Quality of Life Outcomes | 2015 | 235 |
| 46 | Terminology of Dental Caries and Dental Caries Management: Consensus Report of a Workshop Organized by ORCA and Cariology Research Group of IADR | Caries Research | 2020 | 235 |
| 47 | Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio‐Oncology Council of the European Society of Cardiology (ESC) | European Journal of Heart Failure | 2020 | 234 |
| 48 | There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells | Mitochondrion | 2012 | 232 |
| 49 | Accessibility and use of urban green spaces, and cardiovascular health: findings from a Kaunas cohort study | Environmental Health | 2014 | 225 |
| 50 | Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer | Nature Genetics | 2015 | 224 |
