| # | Title | Journal | Year | Citations |
|---|
| 1 | X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy | Nature Genetics | 2001 | 1,648 |
| 2 | Pharmacokinetics of Pegylated Liposomal Doxorubicin | Clinical Pharmacokinetics | 2003 | 1,339 |
| 3 | Pediatric modification of the Montreal classification for inflammatory bowel disease | Inflammatory Bowel Diseases | 2011 | 1,182 |
| 4 | ESPGHAN Revised Porto Criteria for the Diagnosis of Inflammatory Bowel Disease in Children and Adolescents | Journal of Pediatric Gastroenterology and Nutrition | 2014 | 961 |
| 5 | Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease | Journal of Crohn's and Colitis | 2014 | 825 |
| 6 | Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis | Gastroenterology | 2004 | 817 |
| 7 | Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial | Lancet, The | 2016 | 771 |
| 8 | Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline | Endoscopy | 2015 | 678 |
| 9 | Cancer-related pain: a pan-European survey of prevalence, treatment, and patient attitudes | Annals of Oncology | 2009 | 650 |
| 10 | A standardised, generic, validated approach to stratify the magnitude of clinical benefit that can be anticipated from anti-cancer therapies: the European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) | Annals of Oncology | 2015 | 635 |
| 11 | Strategies to Manage the Adverse Effects of Oral Morphine: An Evidence-Based Report | Journal of Clinical Oncology | 2001 | 582 |
| 12 | European Association for Palliative Care (EAPC) recommended framework for the use of sedation in palliative care | Palliative Medicine | 2009 | 566 |
| 13 | Drug Interactions with Tobacco Smoking | Clinical Pharmacokinetics | 1999 | 562 |
| 14 | The Diagnostic Approach to Monogenic Very Early Onset Inflammatory Bowel Disease | Gastroenterology | 2014 | 559 |
| 15 | Advanced heart failure: a position statement of the Heart Failure Association of the European Society of Cardiology | European Journal of Heart Failure | 2018 | 555 |
| 16 | Comparison of Skin-to-Skin (Kangaroo) and Traditional Care: Parenting Outcomes and Preterm Infant Development | Pediatrics | 2002 | 516 |
| 17 | Safety assessment of probiotics for human use | Gut Microbes | 2010 | 513 |
| 18 | Oral Probiotics Prevent Necrotizing Enterocolitis in Very Low Birth Weight Neonates | Journal of Pediatrics | 2005 | 503 |
| 19 | Effectiveness of enzyme replacement therapy in 1028 patients with type 1 Gaucher disease after 2 to 5 years of treatment: a report from the Gaucher Registry | American Journal of Medicine | 2002 | 491 |
| 20 | The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes | Molecular Psychiatry | 2006 | 480 |
| 21 | Gentamicin-Induced Correction of CFTR Function in Patients with Cystic Fibrosis andCFTRStop Mutations | New England Journal of Medicine | 2003 | 473 |
| 22 | ESMO-Magnitude of Clinical Benefit Scale version 1.1 | Annals of Oncology | 2017 | 451 |
| 23 | Coronary Thrombosis and Major Bleeding After PCI With Drug-Eluting Stents | Journal of the American College of Cardiology | 2016 | 445 |
| 24 | Number development and developmental dyscalculia | Developmental Medicine and Child Neurology | 2007 | 432 |
| 25 | Thrombin receptor overexpression in malignant and physiological invasion processes | Nature Medicine | 1998 | 414 |
| 26 | Left atrial appendage closure with amplatzer cardiac plug in atrial fibrillation: Initial european experience | Catheterization and Cardiovascular Interventions | 2011 | 385 |
| 27 | PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia | Nature Genetics | 2019 | 384 |
| 28 | Occurrence of Parkinson's syndrome in type 1 Gaucher disease | QJM - Monthly Journal of the Association of Physicians | 1996 | 376 |
| 29 | Definition and classification of hyperkinetic movements in childhood | Movement Disorders | 2010 | 374 |
| 30 | Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms | Cancer Discovery | 2016 | 372 |
| 31 | Low-dose aspirin and prevention of cranial ischemic complications in giant cell arteritis | Arthritis and Rheumatism | 2004 | 370 |
| 32 | The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach | Nature Reviews Clinical Oncology | 2012 | 352 |
| 33 | Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis | Gastroenterology | 2002 | 333 |
| 34 | Low-level lead-induced neurotoxicity in children: an update on central nervous system effects | Brain Research Reviews | 1998 | 326 |
| 35 | Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood | Human Molecular Genetics | 2012 | 317 |
| 36 | Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: A dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 316 |
| 37 | Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Technical Review | Endoscopy | 2018 | 297 |
| 38 | DEVELOPMENTAL DYSCALCULIA: PREVALENCE AND DEMOGRAPHIC FEATURES | Developmental Medicine and Child Neurology | 1996 | 296 |
| 39 | Effect of tolerance on the evolution of antibiotic resistance under drug combinations | Science | 2020 | 296 |
| 40 | Population-based screening for breast and ovarian cancer risk due to BRCA1 and BRCA2 | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 286 |
| 41 | Beyond muscle destruction: a systematic review of rhabdomyolysis for clinical practice | Critical Care | 2016 | 282 |
| 42 | The minimal detectable change cannot reliably replace the minimal important difference | Journal of Clinical Epidemiology | 2010 | 279 |
| 43 | Ultrasound triggered release of cisplatin from liposomes in murine tumors | Journal of Controlled Release | 2009 | 274 |
| 44 | Validity of a novel computerized cognitive battery for mild cognitive impairment | BMC Geriatrics | 2003 | 263 |
| 45 | High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis | Intensive Care Medicine | 2019 | 254 |
| 46 | Mutant KRAS is a druggable target for pancreatic cancer | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 252 |
| 47 | Breastfeeding and the Use of Human Milk: An Analysis of the American Academy of Pediatrics 2012 Breastfeeding Policy Statement | Breastfeeding Medicine | 2012 | 247 |
| 48 | Worldwide emergence of colistin resistance in Klebsiella pneumoniae from healthy humans and patients in Lao PDR, Thailand, Israel, Nigeria and France owing to inactivation of the PhoP/PhoQ regulator mgrB: an epidemiological and molecular study | International Journal of Antimicrobial Agents | 2014 | 246 |
| 49 | Novel Insights into Wound Healing Sequence of Events | Toxicologic Pathology | 2007 | 244 |
| 50 | NT-Pro-B-type Natriuretic Peptide in Infants and Children: Reference Values Based on Combined Data from Four Studies | Pediatric Cardiology | 2009 | 244 |
