| # | Title | Journal | Year | Citations |
|---|
| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 2 | Peginterferon Alfa-2a plus Ribavirin for Chronic Hepatitis C Virus Infection | New England Journal of Medicine | 2002 | 6,268 |
| 3 | PACKMOL: A package for building initial configurations for molecular dynamics simulations | Journal of Computational Chemistry | 2009 | 5,831 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 5 | Path integral approach to quantum Brownian motion | Physica A: Statistical Mechanics and Its Applications | 1983 | 2,268 |
| 6 | Box-Behnken design: An alternative for the optimization of analytical methods | Analytica Chimica Acta | 2007 | 2,226 |
| 7 | Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response | Nature Medicine | 2006 | 1,865 |
| 8 | Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer | Cell | 2017 | 1,742 |
| 9 | The IPBES Conceptual Framework — connecting nature and people | Current Opinion in Environmental Sustainability | 2015 | 1,658 |
| 10 | InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams | BMC Bioinformatics | 2015 | 1,609 |
| 11 | TFOS DEWS II Epidemiology Report | Ocular Surface | 2017 | 1,490 |
| 12 | The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1 | Epilepsia | 2011 | 1,454 |
| 13 | Natural-based plasticizers and biopolymer films: A review | European Polymer Journal | 2011 | 1,425 |
| 14 | Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial | Lancet Oncology, The | 2005 | 1,400 |
| 15 | A new discrete-time robust stability condition | Systems and Control Letters | 1999 | 1,300 |
| 16 | Normal mode determination in crystals | Journal of Raman Spectroscopy | 1981 | 1,145 |
| 17 | Adipose-derived circulating miRNAs regulate gene expression in other tissues | Nature | 2017 | 1,107 |
| 18 | Determination of the estrous cycle phases of rats: some helpful considerations | Brazilian Journal of Biology | 2002 | 1,097 |
| 19 | Silver nanoparticles: A new view on mechanistic aspects on antimicrobial activity | Nanomedicine: Nanotechnology, Biology, and Medicine | 2016 | 1,082 |
| 20 | Comparison of the genomes of two Xanthomonas pathogens with differing host specificities | Nature | 2002 | 1,074 |
| 21 | O desafio do conhecimento: pesquisa qualitativa em saúde | Ciencia E Saude Coletiva | 2007 | 1,044 |
| 22 | TRY plant trait database – enhanced coverage and open access | Global Change Biology | 2020 | 1,038 |
| 23 | Re-evaluating prokaryotic species | Nature Reviews Microbiology | 2005 | 1,019 |
| 24 | Mitochondria and reactive oxygen species | Free Radical Biology and Medicine | 2009 | 904 |
| 25 | Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity | Journal of Neuroscience | 2009 | 886 |
| 26 | Transesterification of vegetable oils: a review | Journal of the Brazilian Chemical Society | 1998 | 879 |
| 27 | Hyperdominance in the Amazonian Tree Flora | Science | 2013 | 873 |
| 28 | Seven Shortfalls that Beset Large-Scale Knowledge of Biodiversity | Annual Review of Ecology, Evolution, and Systematics | 2015 | 856 |
| 29 | The genome sequence of the plant pathogen Xylella fastidiosa | Nature | 2000 | 827 |
| 30 | International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods | Epilepsia | 2013 | 816 |
| 31 | Mechanistic aspects of biosynthesis of silver nanoparticles by several Fusarium oxysporum strains | Journal of Nanobiotechnology | 2005 | 813 |
| 32 | Amphibian fungal panzootic causes catastrophic and ongoing loss of biodiversity | Science | 2019 | 805 |
| 33 | A new subfamily classification of the Leguminosae based on a taxonomically comprehensive phylogeny: The Legume Phylogeny Working Group (LPWG) | Taxon | 2017 | 803 |
| 34 | ILAE Treatment Guidelines: Evidence-based Analysis of Antiepileptic Drug Efficacy and Effectiveness as Initial Monotherapy for Epileptic Seizures and Syndromes | Epilepsia | 2006 | 782 |
| 35 | Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer | New England Journal of Medicine | 2018 | 782 |
| 36 | Abiotic and Biotic Stresses and Changes in the Lignin Content and Composition in Plants | Journal of Integrative Plant Biology | 2010 | 781 |
| 37 | A global meta‐analysis of the relative extent of intraspecific trait variation in plant communities | Ecology Letters | 2015 | 768 |
| 38 | The Genome of the Natural Genetic Engineer Agrobacterium tumefaciens C58 | Science | 2001 | 741 |
| 39 | Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance | Diabetes | 2007 | 741 |
| 40 | Nanotoxicity of Graphene and Graphene Oxide | Chemical Research in Toxicology | 2014 | 729 |
| 41 | High sustained efficacy of a prophylactic quadrivalent human papillomavirus types 6/11/16/18 L1 virus-like particle vaccine through 5 years of follow-up | British Journal of Cancer | 2006 | 727 |
| 42 | Mitochondrial permeability transition and oxidative stress | FEBS Letters | 2001 | 722 |
| 43 | Mitochondrial damage induced by conditions of oxidative stress | Free Radical Biology and Medicine | 1999 | 720 |
| 44 | Encapsulation efficiency and oxidative stability of flaxseed oil microencapsulated by spray drying using different combinations of wall materials | Journal of Food Engineering | 2013 | 702 |
| 45 | Practical recommendations for the management of diabetes in patients with COVID-19 | Lancet Diabetes and Endocrinology,the | 2020 | 680 |
| 46 | Geographic Distribution of the 20210 G to A Prothrombin Variant | Thrombosis and Haemostasis | 1998 | 675 |
| 47 | Applications of laccases and tyrosinases (phenoloxidases) immobilized on different supports: a review | Enzyme and Microbial Technology | 2002 | 674 |
| 48 | Characterization and engineering of a plastic-degrading aromatic polyesterase | Proceedings of the National Academy of Sciences of the United States of America | 2018 | 632 |
| 49 | Surface active drugs: self-association and interaction with membranes and surfactants. Physicochemical and biological aspects | Biochimica Et Biophysica Acta - Biomembranes | 2000 | 618 |
| 50 | Cyclohexane oxidation continues to be a challenge | Applied Catalysis A: General | 2001 | 604 |
