| # | Title | Journal | Year | Citations |
|---|
| 1 | Biochemistry and molecular cell biology of diabetic complications | Nature | 2001 | 7,641 |
| 2 | New diagnostic criteria for multiple sclerosis: Guidelines for research protocols | Annals of Neurology | 1983 | 7,193 |
| 3 | Autophagy fights disease through cellular self-digestion | Nature | 2008 | 5,714 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 5 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015 | JAMA Oncology | 2017 | 4,254 |
| 6 | Macrophage Diversity Enhances Tumor Progression and Metastasis | Cell | 2010 | 4,106 |
| 7 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 8 | Oxidative Stress and Diabetic Complications | Circulation Research | 2010 | 3,989 |
| 9 | Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages | Science | 2010 | 3,920 |
| 10 | Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage | Nature | 2000 | 3,895 |
| 11 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 12 | Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005–2009 | Epilepsia | 2010 | 3,612 |
| 13 | Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies | Epilepsia | 2010 | 3,400 |
| 14 | A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing | Cell | 2007 | 3,390 |
| 15 | Autophagy regulates lipid metabolism | Nature | 2009 | 3,149 |
| 16 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 17 | Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5 | Science | 1997 | 2,915 |
| 18 | Recent advances in the phencyclidine model of schizophrenia | American Journal of Psychiatry | 1991 | 2,698 |
| 19 | Pembrolizumab plus Chemotherapy for Squamous Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2018 | 2,676 |
| 20 | Stat3 as an Oncogene | Cell | 1999 | 2,610 |
| 21 | Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota | Science | 2015 | 2,539 |
| 22 | Strong Association of De Novo Copy Number Mutations with Autism | Science | 2007 | 2,497 |
| 23 | Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis | Cell | 2006 | 2,377 |
| 24 | Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications | New England Journal of Medicine | 1988 | 2,347 |
| 25 | The adipocyte-secreted protein Acrp30 enhances hepatic insulin action | Nature Medicine | 2001 | 2,334 |
| 26 | An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. | Journal of Experimental Medicine | 1993 | 2,280 |
| 27 | The Global Burden of Cancer 2013 | JAMA Oncology | 2015 | 2,269 |
| 28 | Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2010 | 2,195 |
| 29 | The contribution of de novo coding mutations to autism spectrum disorder | Nature | 2014 | 2,188 |
| 30 | Natural History of Cervicovaginal Papillomavirus Infection in Young Women | New England Journal of Medicine | 1998 | 2,116 |
| 31 | An integrated map of structural variation in 2,504 human genomes | Nature | 2015 | 1,994 |
| 32 | Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA | Cell | 1997 | 1,988 |
| 33 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 34 | A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains | Nature Medicine | 2000 | 1,945 |
| 35 | Prevalence and Burden of Migraine in the United States: Data From the American Migraine Study II | Headache | 2001 | 1,933 |
| 36 | The Global Burden of Headache: A Documentation of Headache Prevalence and Disability Worldwide | Cephalalgia | 2007 | 1,911 |
| 37 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 38 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
| 39 | Adipose Tissue, Inflammation, and Cardiovascular Disease | Circulation Research | 2005 | 1,779 |
| 40 | Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care | World Psychiatry | 2011 | 1,767 |
| 41 | Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes | Immunity | 2013 | 1,767 |
| 42 | Antibodies to von Willebrand Factor–Cleaving Protease in Acute Thrombotic Thrombocytopenic Purpura | New England Journal of Medicine | 1998 | 1,763 |
| 43 | Impaired Degradation of Mutant -Synuclein by Chaperone-Mediated Autophagy | Science | 2004 | 1,762 |
| 44 | Geroscience: Linking Aging to Chronic Disease | Cell | 2014 | 1,709 |
| 45 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 | JAMA Oncology | 2019 | 1,691 |
| 46 | Guidelines for using human event-related potentials to study cognition: Recording standards and publication criteria | Psychophysiology | 2000 | 1,682 |
| 47 | Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders | Pharmacogenetics and Genomics | 1996 | 1,681 |
| 48 | 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation | Heart Rhythm | 2017 | 1,671 |
| 49 | A definition and classification of status epilepticus – Report of the ILAE Task Force on Classification of Status Epilepticus | Epilepsia | 2015 | 1,630 |
| 50 | Characteristics Associated with Liver Graft Failure: The Concept of a Donor Risk Index | American Journal of Transplantation | 2006 | 1,624 |
