| # | Title | Journal | Year | Citations |
|---|
| 1 | Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria | Annals of Neurology | 2011 | 8,001 |
| 2 | Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Scale presentation and clinimetric testing results | Movement Disorders | 2008 | 4,796 |
| 3 | An integrated map of structural variation in 2,504 human genomes | Nature | 2015 | 1,994 |
| 4 | A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease | Annals of Neurology | 2003 | 1,450 |
| 5 | Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation | Cell | 2011 | 1,285 |
| 6 | Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Process, format, and clinimetric testing plan | Movement Disorders | 2007 | 1,097 |
| 7 | Dendritic-cell trafficking to lymph nodes through lymphatic vessels | Nature Reviews Immunology | 2005 | 989 |
| 8 | Diagnostic procedures for Parkinson's disease dementia: Recommendations from the movement disorder society task force | Movement Disorders | 2007 | 885 |
| 9 | International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: The NMSQuest study | Movement Disorders | 2006 | 865 |
| 10 | Variable generalization performance of a deep learning model to detect pneumonia in chest radiographs: A cross-sectional study | PLoS Medicine | 2018 | 771 |
| 11 | American Association of Clinical Endocrinologists and American College of Endocrinology Guidelines for Management of Dyslipidemia and Prevention of Cardiovascular Disease | Endocrine Practice | 2017 | 766 |
| 12 | Artificial intelligence–enabled rapid diagnosis of patients with COVID-19 | Nature Medicine | 2020 | 757 |
| 13 | Identification of a serotonin/glutamate receptor complex implicated in psychosis | Nature | 2008 | 739 |
| 14 | Aerosol emission and superemission during human speech increase with voice loudness | Scientific Reports | 2019 | 709 |
| 15 | Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey | Journal of Extracellular Vesicles | 2016 | 703 |
| 16 | Hallucinogens Recruit Specific Cortical 5-HT2A Receptor-Mediated Signaling Pathways to Affect Behavior | Neuron | 2007 | 692 |
| 17 | The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond | Trends in Cell Biology | 2010 | 687 |
| 18 | The scientific and clinical basis for the treatment of Parkinson disease (2009) | Neurology | 2009 | 685 |
| 19 | A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments | Nature Medicine | 2018 | 679 |
| 20 | Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome | Nature | 2010 | 672 |
| 21 | PD-L1 as a biomarker of response to immune-checkpoint inhibitors | Nature Reviews Clinical Oncology | 2021 | 646 |
| 22 | Von Hippel–Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma | Nature | 1988 | 629 |
| 23 | Understanding cell death in parkinson's disease | Annals of Neurology | 1998 | 605 |
| 24 | Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial | Lancet Neurology, The | 2010 | 589 |
| 25 | An algorithm (decision tree) for the management of Parkinson’s disease (2001): | Neurology | 2001 | 565 |
| 26 | Repurposing Diflunisal for Familial Amyloid Polyneuropathy | JAMA - Journal of the American Medical Association | 2013 | 551 |
| 27 | Early dissemination seeds metastasis in breast cancer | Nature | 2016 | 550 |
| 28 | Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial | Lancet Neurology, The | 2008 | 529 |
| 29 | VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 529 |
| 30 | Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication | Molecular Autism | 2010 | 521 |
| 31 | Wdr5 Mediates Self-Renewal and Reprogramming via the Embryonic Stem Cell Core Transcriptional Network | Cell | 2011 | 521 |
| 32 | Brain charts for the human lifespan | Nature | 2022 | 518 |
| 33 | Influenza A viruses: new research developments | Nature Reviews Microbiology | 2011 | 511 |
| 34 | Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 507 |
| 35 | Failure of the ubiquitin–proteasome system in Parkinson's disease | Nature Reviews Neuroscience | 2001 | 490 |
| 36 | Continuous dopamine-receptor treatment of Parkinson's disease: scientific rationale and clinical implications | Lancet Neurology, The | 2006 | 461 |
| 37 | Fetal nigral transplantation as a therapy for Parkinson's disease | Trends in Neurosciences | 1996 | 455 |
| 38 | Accuracy and calibration of commercial oligonucleotide and custom cDNA microarrays | Nucleic Acids Research | 2002 | 453 |
| 39 | Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions | Nature Cell Biology | 1999 | 444 |
| 40 | Volume of ventricular blood is an important determinant of outcome in supratentorial intracerebral hemorrhage | Critical Care Medicine | 1999 | 442 |
| 41 | Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C) | Cell | 2020 | 440 |
| 42 | Ambulatory monitoring of freezing of gait in Parkinson's disease | Journal of Neuroscience Methods | 2008 | 424 |
| 43 | Manganese-Induced Parkinsonism and Parkinson's Disease | Annals of the New York Academy of Sciences | 2004 | 423 |
| 44 | Antiphospholipid Antibodies and Subsequent Thrombo-occlusive Events in Patients With Ischemic Stroke | JAMA - Journal of the American Medical Association | 2004 | 405 |
| 45 | Consensus Statement By The American Association Of Clinical Endocrinologists And American College Of Endocrinology On The Comprehensive Type 2 Diabetes Management Algorithm – 2016 EXECUTIVE SUMMARY | Endocrine Practice | 2016 | 405 |
| 46 | Levodopa motor complications in Parkinson's disease | Trends in Neurosciences | 2000 | 393 |
| 47 | Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia | Nature Neuroscience | 2009 | 390 |
| 48 | Tendinopathy | Nature Reviews Disease Primers | 2021 | 388 |
| 49 | Mutations in the THAP1 gene are responsible for DYT6 primary torsion dystonia | Nature Genetics | 2009 | 384 |
| 50 | Cortical 5-HT2A Receptor Signaling Modulates Anxiety-Like Behaviors in Mice | Science | 2006 | 375 |
