| # | Title | Journal | Year | Citations |
|---|
| 1 | The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments | Clinical Chemistry | 2009 | 12,487 |
| 2 | Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging | Journal of the American Society of Echocardiography | 2015 | 10,755 |
| 3 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,038 |
| 4 | Biological properties of extracellular vesicles and their physiological functions | Journal of Extracellular Vesicles | 2015 | 3,973 |
| 5 | qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data | Genome Biology | 2007 | 3,580 |
| 6 | Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease | Nature Genetics | 2008 | 2,422 |
| 7 | Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci | Nature Genetics | 2010 | 2,284 |
| 8 | Chronic Kidney Disease | Lancet, The | 2017 | 2,274 |
| 9 | ESUR prostate MR guidelines 2012 | European Radiology | 2012 | 2,176 |
| 10 | Immunogenic cell death and DAMPs in cancer therapy | Nature Reviews Cancer | 2012 | 1,984 |
| 11 | Autoantibodies against type I IFNs in patients with life-threatening COVID-19 | Science | 2020 | 1,983 |
| 12 | Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study | Intensive Care Medicine | 2015 | 1,838 |
| 13 | Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 | Science | 2020 | 1,749 |
| 14 | Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1) | Critical Care | 2013 | 1,724 |
| 15 | The revised Ghent nosology for the Marfan syndrome | Journal of Medical Genetics | 2010 | 1,677 |
| 16 | Definition, evaluation, and classification of renal osteodystrophy: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO) | Kidney International | 2006 | 1,586 |
| 17 | European Position Paper on Rhinosinusitis and Nasal Polyps 2020 | Rhinology | 2020 | 1,555 |
| 18 | A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2 | Nature Genetics | 2005 | 1,543 |
| 19 | Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. I. Definitions | Intensive Care Medicine | 2006 | 1,507 |
| 20 | Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 | Intensive Care Medicine | 2021 | 1,503 |
| 21 | Aortic Pulse Wave Velocity Improves Cardiovascular Event Prediction | Journal of the American College of Cardiology | 2014 | 1,446 |
| 22 | Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society* Clinical Practice Guideline | Journal of Clinical Endocrinology and Metabolism | 2017 | 1,442 |
| 23 | Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. II. Recommendations | Intensive Care Medicine | 2007 | 1,432 |
| 24 | Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21 | Nature | 2006 | 1,386 |
| 25 | FlowSOM: Using self‐organizing maps for visualization and interpretation of cytometry data | Cytometry Part A: the Journal of the International Society for Analytical Cytology | 2015 | 1,337 |
| 26 | Prostate Imaging Reporting and Data System Version 2.1: 2019 Update of Prostate Imaging Reporting and Data System Version 2 | European Urology | 2019 | 1,270 |
| 27 | miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis | Nature Cell Biology | 2010 | 1,216 |
| 28 | Identification of ALK as a major familial neuroblastoma predisposition gene | Nature | 2008 | 1,207 |
| 29 | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 | Nature Genetics | 2011 | 1,201 |
| 30 | Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines—2016 revision | Journal of Allergy and Clinical Immunology | 2017 | 1,199 |
| 31 | Intra-abdominal hypertension and the abdominal compartment syndrome: updated consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome | Intensive Care Medicine | 2013 | 1,197 |
| 32 | Micafungin versus liposomal amphotericin B for candidaemia and invasive candidosis: a phase III randomised double-blind trial | Lancet, The | 2007 | 1,185 |
| 33 | The Standardization of Terminology of Lower Urinary Tract Function in Children and Adolescents: Report from the Standardisation Committee of the International Children’s Continence Society | Journal of Urology | 2006 | 1,148 |
| 34 | The Glymphatic Hypothesis of Glaucoma: A Unifying Concept Incorporating Vascular, Biomechanical, and Biochemical Aspects of the Disease | BioMed Research International | 2017 | 1,089 |
| 35 | Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation | PLoS Biology | 2012 | 1,064 |
| 36 | Recent Developments in Myofibroblast Biology | American Journal of Pathology | 2012 | 1,043 |
| 37 | A comparison of single-cell trajectory inference methods | Nature Biotechnology | 2019 | 1,038 |
| 38 | Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper | Journal of Extracellular Vesicles | 2015 | 1,020 |
| 39 | Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury | Critical Care | 2013 | 969 |
| 40 | Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup | Nature Reviews Nephrology | 2017 | 946 |
| 41 | Small-cell lung cancer | Lancet, The | 2011 | 941 |
| 42 | The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications | Endocrine Reviews | 2005 | 938 |
| 43 | Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials | Lancet Respiratory Medicine,the | 2015 | 937 |
| 44 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021 | Critical Care Medicine | 2021 | 927 |
| 45 | Clinical and Economic Outcomes in Critically Ill Patients with Nosocomial Catheter-Related Bloodstream Infections | Clinical Infectious Diseases | 2005 | 899 |
| 46 | Polyphasic taxonomy, a consensus approach to bacterial systematics. | Microbiological Reviews | 1996 | 892 |
| 47 | Role of tissue stroma in cancer cell invasion | Journal of Pathology | 2003 | 878 |
| 48 | European Resuscitation Council Guidelines for Resuscitation 2010 Section 2. Adult basic life support and use of automated external defibrillators | Resuscitation | 2010 | 877 |
| 49 | A novel and universal method for microRNA RT-qPCR data normalization | Genome Biology | 2009 | 849 |
| 50 | Burden and clinical features of chronic obstructive pulmonary disease (COPD) | Lancet, The | 2004 | 844 |
