| # | Title | Journal | Year | Citations |
|---|
| 1 | Molecular portraits of human breast tumours | Nature | 2000 | 13,397 |
| 2 | Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol | Lancet, The | 2002 | 4,917 |
| 3 | Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma | Clinical Cancer Research | 2004 | 2,393 |
| 4 | Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial | Lancet, The | 2008 | 1,759 |
| 5 | Approaches to Catheter Ablation for Persistent Atrial Fibrillation | New England Journal of Medicine | 2015 | 1,725 |
| 6 | Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery Disease | New England Journal of Medicine | 1997 | 1,626 |
| 7 | Hydroxyethyl Starch 130/0.42 versus Ringer's Acetate in Severe Sepsis | New England Journal of Medicine | 2012 | 1,594 |
| 8 | Epidemiology of Parkinson’s disease | Journal of Neural Transmission | 2017 | 1,593 |
| 9 | Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol | Lancet, The | 2002 | 1,520 |
| 10 | Genome-wide association study identifies 30 loci associated with bipolar disorder | Nature Genetics | 2019 | 1,191 |
| 11 | FTO Obesity Variant Circuitry and Adipocyte Browning in Humans | New England Journal of Medicine | 2015 | 1,105 |
| 12 | Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial | Lancet Oncology, The | 2013 | 1,017 |
| 13 | EFSUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography. Part 1: Basic Principles and Technology | Ultraschall in Der Medizin | 2013 | 961 |
| 14 | 2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents | Journal of Hypertension | 2016 | 898 |
| 15 | Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence | Nature Genetics | 2018 | 893 |
| 16 | Randomised trial of effects of calcium antagonists compared with diuretics and β-blockers on cardiovascular morbidity and mortality in hypertension: the Nordic Diltiazem (NORDIL) study | Lancet, The | 2000 | 876 |
| 17 | Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients | Nature Medicine | 1996 | 797 |
| 18 | Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal neuroendocrine carcinoma (WHO G3): The NORDIC NEC study | Annals of Oncology | 2013 | 792 |
| 19 | EFSUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography.Part 2: Clinical Applications | Ultraschall in Der Medizin | 2013 | 780 |
| 20 | Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies | PLoS Medicine | 2010 | 764 |
| 21 | Practice guidelines for performance of the routine mid‐trimester fetal ultrasound scan | Ultrasound in Obstetrics and Gynecology | 2011 | 760 |
| 22 | Recommendations for interpretation of 12-lead electrocardiogram in the athlete | European Heart Journal | 2010 | 730 |
| 23 | High sustained efficacy of a prophylactic quadrivalent human papillomavirus types 6/11/16/18 L1 virus-like particle vaccine through 5 years of follow-up | British Journal of Cancer | 2006 | 727 |
| 24 | Subclonal diversification of primary breast cancer revealed by multiregion sequencing | Nature Medicine | 2015 | 711 |
| 25 | Landscape of genomic alterations in cervical carcinomas | Nature | 2014 | 708 |
| 26 | European Resuscitation Council Guidelines for Resuscitation 2015 | Resuscitation | 2015 | 696 |
| 27 | Comparison of different methods for measuring intra-abdominal pressure | Intensive Care Medicine | 2002 | 681 |
| 28 | Single Cell Profiling of Potentiated Phospho-Protein Networks in Cancer Cells | Cell | 2004 | 655 |
| 29 | 450K Epigenome-Wide Scan Identifies Differential DNA Methylation in Newborns Related to Maternal Smoking during Pregnancy | Environmental Health Perspectives | 2012 | 654 |
| 30 | Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology | Nature Genetics | 2021 | 629 |
| 31 | Percutaneous coronary angioplasty versus coronary artery bypass grafting in treatment of unprotected left main stenosis (NOBLE): a prospective, randomised, open-label, non-inferiority trial | Lancet, The | 2016 | 620 |
| 32 | Percutaneous Mechanical Circulatory Support Versus Intra-Aortic Balloon Pump in Cardiogenic Shock After Acute Myocardial Infarction | Journal of the American College of Cardiology | 2017 | 612 |
| 33 | Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines | Journal of Experimental Medicine | 2010 | 593 |
| 34 | Long-term Cultures of Bone Marrow–Derived Human Mesenchymal Stem Cells Frequently Undergo Spontaneous Malignant Transformation | Cancer Research | 2009 | 590 |
| 35 | The HELLP syndrome: Clinical issues and management. A Review | BMC Pregnancy and Childbirth | 2009 | 587 |
| 36 | Formation of new chromatin domains determines pathogenicity of genomic duplications | Nature | 2016 | 582 |
| 37 | Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study | Lancet Oncology, The | 2010 | 576 |
| 38 | Preeclampsia and the Risk of End-Stage Renal Disease | New England Journal of Medicine | 2008 | 569 |
| 39 | Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial | Lancet, The | 2009 | 551 |
| 40 | Rare and low-frequency coding variants alter human adult height | Nature | 2017 | 544 |
| 41 | Vitamin B12 deficiency | Nature Reviews Disease Primers | 2017 | 543 |
| 42 | Chronic Insomnia as a Risk Factor for Developing Anxiety and Depression | Sleep | 2007 | 541 |
| 43 | The variability of critical care bed numbers in Europe | Intensive Care Medicine | 2012 | 529 |
| 44 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer | Nature Genetics | 2013 | 493 |
| 45 | Effective behaviour change techniques for physical activity and healthy eating in overweight and obese adults; systematic review and meta-regression analyses | International Journal of Behavioral Nutrition and Physical Activity | 2017 | 484 |
| 46 | A Switch from E-Cadherin to N-Cadherin Expression Indicates Epithelial to Mesenchymal Transition and Is of Strong and Independent Importance for the Progress of Prostate Cancer | Clinical Cancer Research | 2007 | 472 |
| 47 | Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer | Genes Chromosomes and Cancer | 2006 | 464 |
| 48 | Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: a randomised, multicentre, placebo-controlled phase II study | Lancet Oncology, The | 2007 | 461 |
| 49 | Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder | Nature | 2015 | 461 |
| 50 | The Norwegian Arthroplasty Register: 11 years and 73,000 arthroplasties | Acta Orthopaedica | 2000 | 455 |
