| # | Title | Journal | Year | Citations |
|---|
| 1 | Identification and Importance of Brown Adipose Tissue in Adult Humans | New England Journal of Medicine | 2009 | 3,690 |
| 2 | Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders | New England Journal of Medicine | 1994 | 3,519 |
| 3 | Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein | Science | 2002 | 2,159 |
| 4 | Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role ofPGC1andNRF1 | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 1,800 |
| 5 | Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters | Nature Medicine | 2009 | 1,790 |
| 6 | Suppression of Aging in Mice by the Hormone Klotho | Science | 2005 | 1,634 |
| 7 | Disruption of IRS-2 causes type 2 diabetes in mice | Nature | 1998 | 1,607 |
| 8 | Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein | Nature | 1991 | 1,516 |
| 9 | The insulin signaling system | Journal of Biological Chemistry | 1994 | 1,333 |
| 10 | Antioxidants prevent health-promoting effects of physical exercise in humans | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 1,315 |
| 11 | Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase | Nature | 2000 | 1,307 |
| 12 | A role for melanin-concentrating hormone in the central regulation of feeding behaviour | Nature | 1996 | 1,259 |
| 13 | Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle | Journal of Biological Chemistry | 2002 | 1,254 |
| 14 | The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307 | Journal of Biological Chemistry | 2000 | 1,216 |
| 15 | Protein glycosylation: nature, distribution, enzymatic formation, and disease implications of glycopeptide bonds | Glycobiology | 2002 | 1,210 |
| 16 | Protein kinase C activation and the development of diabetic complications | Diabetes | 1998 | 1,197 |
| 17 | Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene | Nature | 1994 | 1,195 |
| 18 | IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice | Cell | 2004 | 1,189 |
| 19 | Effects of Saline, Mannitol, and Furosemide on Acute Decreases in Renal Function Induced by Radiocontrast Agents | New England Journal of Medicine | 1994 | 1,186 |
| 20 | Care of Children and Adolescents With Type 1 Diabetes: A statement of the American Diabetes Association | Diabetes Care | 2005 | 1,174 |
| 21 | Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats | Diabetes | 1999 | 1,161 |
| 22 | Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study | Lancet, The | 1992 | 1,093 |
| 23 | Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes | Cell | 1999 | 1,093 |
| 24 | Mice lacking melanin-concentrating hormone are hypophagic and lean | Nature | 1998 | 1,085 |
| 25 | Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC beta Inhibitor | Science | 1996 | 1,083 |
| 26 | Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction | Molecular Cell | 2000 | 1,077 |
| 27 | Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes | Diabetes/Metabolism Research and Reviews | 1999 | 1,065 |
| 28 | Diabetes in Older Adults | Diabetes Care | 2012 | 961 |
| 29 | TRANSCRIPTIONAL REGULATION BY CYCLIC AMP | Annual Review of Biochemistry | 1997 | 926 |
| 30 | STAT3 signalling is required for leptin regulation of energy balance but not reproduction | Nature | 2003 | 914 |
| 31 | EXERCISE, GLUCOSE TRANSPORT, AND INSULIN SENSITIVITY | Annual Review of Medicine | 1998 | 874 |
| 32 | Role of IRS-2 in insulin and cytokine signalling | Nature | 1995 | 834 |
| 33 | Diabetes primes neutrophils to undergo NETosis, which impairs wound healing | Nature Medicine | 2015 | 824 |
| 34 | Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist | Cell Metabolism | 2015 | 823 |
| 35 | Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action | Journal of Biological Chemistry | 2002 | 809 |
| 36 | IRS proteins and the common path to diabetes | American Journal of Physiology - Endocrinology and Metabolism | 2002 | 757 |
| 37 | SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2 | Journal of Biological Chemistry | 2002 | 744 |
| 38 | Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications | Circulation Research | 2010 | 743 |
| 39 | Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes | Diabetes | 2002 | 722 |
| 40 | Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance | Journal of Clinical Investigation | 1999 | 721 |
| 41 | Regression of Microalbuminuria in Type 1 Diabetes | New England Journal of Medicine | 2003 | 719 |
| 42 | Solution Structure of the KIX Domain of CBP Bound to the Transactivation Domain of CREB: A Model for Activator:Coactivator Interactions | Cell | 1997 | 705 |
| 43 | Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates | Nature Materials | 2015 | 700 |
| 44 | Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia | Diabetes | 1994 | 690 |
| 45 | The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells | Journal of Experimental Medicine | 2008 | 683 |
| 46 | Predisposition to Hypertension and Susceptibility to Renal Disease in Insulin-Dependent Diabetes Mellitus | New England Journal of Medicine | 1988 | 665 |
| 47 | Insulin Action and the Insulin Signaling Network* | Endocrine Reviews | 1995 | 664 |
| 48 | Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells | Nature | 1985 | 661 |
| 49 | A guide to analysis of mouse energy metabolism | Nature Methods | 2012 | 655 |
| 50 | Vascular Endothelial Growth Factor–Induced Retinal Permeability Is Mediated by Protein Kinase C In Vivo and Suppressed by an Orally Effective β-Isoform–Selective Inhibitor | Diabetes | 1997 | 642 |
