| # | Title | Journal | Year | Citations |
|---|
| 1 | The Use of the Morris Water Maze in the Study of Memory and Learning | International Journal of Neuroscience | 1989 | 559 |
| 2 | The coding capacity of SARS-CoV-2 | Nature | 2021 | 464 |
| 3 | A Molecular Basis for Insulin Resistance | Journal of Biological Chemistry | 1997 | 459 |
| 4 | Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept | Journal of Medicinal Chemistry | 2017 | 433 |
| 5 | M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice | Neuron | 2006 | 383 |
| 6 | Chemical Basis of Hashish Activity | Science | 1970 | 306 |
| 7 | Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket | Journal of Biological Chemistry | 1993 | 297 |
| 8 | Antibody Recognition and Neutralization Determinants on Domains I and II of West Nile Virus Envelope Protein | Journal of Virology | 2006 | 272 |
| 9 | Exportation of Monkeypox Virus From the African Continent | Journal of Infectious Diseases | 2022 | 236 |
| 10 | Diagnosis of canine monocytotropic ehrlichiosis (Ehrlichia canis): An overview | Veterinary Journal | 2011 | 223 |
| 11 | AF64A, a cholinergic neurotoxin, selectively depletes acetylcholine in hippocampus and cortex, and produces long-term passive avoidance and radial-arm maze deficits in the rat | Brain Research | 1984 | 218 |
| 12 | Search for Correlates of Protective Immunity Conferred by Anthrax Vaccine | Infection and Immunity | 2001 | 217 |
| 13 | Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice | Neuroscience Letters | 1995 | 207 |
| 14 | Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket | Journal of Biological Chemistry | 1993 | 206 |
| 15 | Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center. | EMBO Journal | 1992 | 205 |
| 16 | Prophylactic and Therapeutic Efficacy of Human Intravenous Immunoglobulin in Treating West Nile Virus Infection in Mice | Journal of Infectious Diseases | 2003 | 204 |
| 17 | Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity | Biochemical Pharmacology | 1993 | 202 |
| 18 | CF2H, a Functional Group-Dependent Hydrogen-Bond Donor: Is It a More or Less Lipophilic Bioisostere of OH, SH, and CH3? | Journal of Medicinal Chemistry | 2019 | 196 |
| 19 | NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis | Nature Communications | 2019 | 190 |
| 20 | The Stoichiometry of Protection against Soman and VX Toxicity in Monkeys Pretreated with Human Butyrylcholinesterase | Toxicology and Applied Pharmacology | 1997 | 180 |
| 21 | Selective Inhibition of Ras-dependent Cell Growth by Farnesylthiosalisylic Acid | Journal of Biological Chemistry | 1995 | 178 |
| 22 | A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge | Nature Communications | 2020 | 177 |
| 23 | Polykaryocytosis induced by newcastle disease virus in monolayers of animal cells | Virology | 1965 | 174 |
| 24 | Psychopharmacological activity of the active constituents of hashish and some related cannabinoids | Psychopharmacology | 1969 | 171 |
| 25 | Aging of phosphylated human acetylcholinesterase: catalytic processes mediated by aromatic and polar residues of the active centre | Biochemical Journal | 1996 | 166 |
| 26 | Critical microcarrier properties affecting the expansion of undifferentiated human embryonic stem cells | Stem Cell Research | 2011 | 166 |
| 27 | Study of thermal comfort in courtyards in a hot arid climate | Solar Energy | 2012 | 164 |
| 28 | The effects of long-term corticosterone administration on hippocampal morphology and cognitive performance of middle-aged rats | Brain Research | 1994 | 162 |
| 29 | Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core. | Journal of Biological Chemistry | 1994 | 161 |
| 30 | Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding. | Journal of Biological Chemistry | 1992 | 159 |
| 31 | Inhibition of Acetylcholinesterase and Butyrylcholinesterase by Chlorpyrifos-oxon | Biochemical Pharmacology | 1998 | 145 |
| 32 | Inhibition of Virus Multiplication by Foreign Nucleic Acid | Nature | 1963 | 144 |
| 33 | Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in mice | Biochemical Pharmacology | 1991 | 142 |
| 34 | Effect of ultrasound on transdermal drug delivery to rats and guinea pigs. | Journal of Clinical Investigation | 1989 | 141 |
| 35 | Age-related structural changes in the rat hippocampus: correlation with working memory deficiency | Brain Research | 1990 | 140 |
| 36 | Functional Characteristics of the Oxyanion Hole in Human Acetylcholinesterase | Journal of Biological Chemistry | 1998 | 139 |
| 37 | M1 Muscarinic Agonists Can Modulate Some of the Hallmarks in Alzheimer's Disease: Implications in Future Therapy | Journal of Molecular Neuroscience | 2003 | 138 |
| 38 | Attenuated Nontoxinogenic and Nonencapsulated Recombinant Bacillus anthracis Spore Vaccines Protect against Anthrax | Infection and Immunity | 2000 | 136 |
| 39 | Fat transport in the locust | Journal of Lipid Research | 1962 | 135 |
| 40 | A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes | Nature Communications | 2020 | 134 |
| 41 | West Nile virus neuroinvasion and encephalitis induced by macrophage depletion in mice | Archives of Virology | 1996 | 133 |
| 42 | Cholinergic Treatments with Emphasis on M1 Muscarinic Agonists as Potential Disease-Modifying Agents for Alzheimer's Disease | Neurotherapeutics | 2008 | 130 |
| 43 | Fat synthesis in cell-free preparations of the locust fat-body | Journal of Lipid Research | 1961 | 126 |
| 44 | Activation of m1 Muscarinic Acetylcholine Receptor Regulates τ Phosphorylation in Transfected PC12 Cells | Journal of Neurochemistry | 1996 | 125 |
| 45 | Dehydroepiandrosterone protects mice from endotoxin toxicity and reduces tumor necrosis factor production | Antimicrobial Agents and Chemotherapy | 1992 | 124 |
| 46 | Microcebus murinus: a useful primate model for human cerebral aging and Alzheimer's disease? | Genes, Brain and Behavior | 2006 | 123 |
| 47 | Feeding Response in Aedes aegypti: Stimulation by Adenosine Triphosphate | Science | 1963 | 122 |
| 48 | Protective effects of melatonin in mice infected with encephalitis viruses | Archives of Virology | 1995 | 122 |
| 49 | Discrete activation of transduction pathways associated with acetylcholine m1 receptor by several muscarinic ligands | European Journal of Pharmacology | 1994 | 121 |
| 50 | Estimation of the Upper Limit of Human Butyrylcholinesterase Dose Required for Protection against Organophosphates Toxicity: a Mathematically Based Toxicokinetic Model | Toxicological Sciences | 2004 | 121 |
