| # | Title | Journal | Year | Citations |
|---|
| 1 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 2 | Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer | Science | 2009 | 2,730 |
| 3 | FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0 | European Journal of Nuclear Medicine and Molecular Imaging | 2015 | 2,188 |
| 4 | DNA methylation-based classification of central nervous system tumours | Nature | 2018 | 1,872 |
| 5 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 6 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 7 | Genome-wide association study identifies 30 loci associated with bipolar disorder | Nature Genetics | 2019 | 1,191 |
| 8 | FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0 | European Journal of Nuclear Medicine and Molecular Imaging | 2010 | 1,147 |
| 9 | Mesenchymal Stem Cells Can Be Differentiated Into Endothelial Cells In Vitro | Stem Cells | 2004 | 1,143 |
| 10 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 11 | Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial | Lancet, The | 2014 | 1,008 |
| 12 | Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial | Lancet Oncology, The | 2010 | 873 |
| 13 | A meta-analysis of structural brain abnormalities in PTSD | Neuroscience and Biobehavioral Reviews | 2006 | 788 |
| 14 | Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis | Journal of Experimental Medicine | 2011 | 739 |
| 15 | Expanding global access to radiotherapy | Lancet Oncology, The | 2015 | 709 |
| 16 | Radiation oncology in the era of precision medicine | Nature Reviews Cancer | 2016 | 636 |
| 17 | Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology | Nature Genetics | 2021 | 629 |
| 18 | Obesity accelerates epigenetic aging of human liver | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 620 |
| 19 | Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity | Blood | 2011 | 612 |
| 20 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial | Lancet Oncology, The | 2012 | 585 |
| 21 | Oxaliplatin added to fluorouracil-based preoperative chemoradiotherapy and postoperative chemotherapy of locally advanced rectal cancer (the German CAO/ARO/AIO-04 study): final results of the multicentre, open-label, randomised, phase 3 trial | Lancet Oncology, The | 2015 | 577 |
| 22 | Neoadjuvant treatment of unresectable colorectal liver metastases: correlation between tumour response and resection rates | Annals of Oncology | 2005 | 560 |
| 23 | Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group | Molecular Psychiatry | 2018 | 558 |
| 24 | Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy | European Journal of Cancer | 2016 | 546 |
| 25 | 2015 Gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative | Annals of the Rheumatic Diseases | 2015 | 545 |
| 26 | Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma | Nature Medicine | 2019 | 541 |
| 27 | Clinical picture and treatment of 2212 patients with common variable immunodeficiency | Journal of Allergy and Clinical Immunology | 2014 | 512 |
| 28 | Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation | Science Translational Medicine | 2017 | 512 |
| 29 | Neurological, respiratory, musculoskeletal, cardiac and ocular side-effects of anti-PD-1 therapy | European Journal of Cancer | 2016 | 490 |
| 30 | Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta‐analysis | Acta Psychiatrica Scandinavica | 2013 | 481 |
| 31 | Local Treatment of Unresectable Colorectal Liver Metastases: Results of a Randomized Phase II Trial | Journal of the National Cancer Institute | 2017 | 466 |
| 32 | ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer | Radiotherapy and Oncology | 2015 | 462 |
| 33 | Protective Mechanical Ventilation during General Anesthesia for Open Abdominal Surgery Improves Postoperative Pulmonary Function | Anesthesiology | 2013 | 416 |
| 34 | Association between driving pressure and development of postoperative pulmonary complications in patients undergoing mechanical ventilation for general anaesthesia: a meta-analysis of individual patient data | Lancet Respiratory Medicine,the | 2016 | 404 |
| 35 | 2015 Gout Classification Criteria: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative | Arthritis and Rheumatology | 2015 | 393 |
| 36 | Association of Type and Location ofBRCA1andBRCA2Mutations With Risk of Breast and Ovarian Cancer | JAMA - Journal of the American Medical Association | 2015 | 390 |
| 37 | Treatment of patients with advanced cancer with the natural killer cell line NK-92 | Cytotherapy | 2013 | 386 |
| 38 | Discovery of common and rare genetic risk variants for colorectal cancer | Nature Genetics | 2019 | 377 |
| 39 | Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients | Cancer Cell | 2016 | 375 |
| 40 | Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation | Blood | 2009 | 366 |
| 41 | Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study | Lancet Diabetes and Endocrinology,the | 2019 | 364 |
| 42 | Variation of human milk oligosaccharides in relation to milk groups and lactational periods | British Journal of Nutrition | 2010 | 361 |
| 43 | Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer | Nature Genetics | 2017 | 356 |
| 44 | Adjuvant Radiotherapy Versus Wait-and-See After Radical Prostatectomy: 10-year Follow-up of the ARO 96–02/AUO AP 09/95 Trial | European Urology | 2014 | 354 |
| 45 | The Psoriasis Area and Severity Index Is the Adequate Criterion to Define Severity in Chronic Plaque-Type Psoriasis | Dermatology | 2005 | 353 |
| 46 | The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach | Nature Reviews Clinical Oncology | 2012 | 352 |
| 47 | Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion* | Anaesthesia | 2006 | 345 |
| 48 | Big Endothelin-1 and Endothelin-1 Plasma Levels Are Correlated With the Severity of Primary Pulmonary Hypertension | Chest | 2001 | 344 |
| 49 | Effects and safety of rituximab in systemic sclerosis: an analysis from the European Scleroderma Trial and Research (EUSTAR) group | Annals of the Rheumatic Diseases | 2015 | 340 |
| 50 | World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders in Primary Care | World Journal of Biological Psychiatry | 2007 | 335 |
