| # | Title | Journal | Year | Citations |
|---|
| 1 | Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013 | Lancet, The | 2015 | 2,159 |
| 2 | An updated evolutionary classification of CRISPR–Cas systems | Nature Reviews Microbiology | 2015 | 2,081 |
| 3 | antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters | Nucleic Acids Research | 2015 | 1,764 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 5 | Global, regional, and national levels and causes of maternal mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 1,230 |
| 6 | Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation | Science | 2014 | 938 |
| 7 | Salmonella enterica Serovar Typhimurium Exploits Inflammation to Compete with the Intestinal Microbiota | PLoS Biology | 2007 | 905 |
| 8 | Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 786 |
| 9 | Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) | European Journal of Immunology | 2019 | 766 |
| 10 | Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 765 |
| 11 | Eleven grand challenges in single-cell data science | Genome Biology | 2020 | 742 |
| 12 | The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA | Nature | 2016 | 737 |
| 13 | De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells | Nature Medicine | 2014 | 694 |
| 14 | Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse | Science | 2009 | 680 |
| 15 | Critical Assessment of Metagenome Interpretation—a benchmark of metagenomics software | Nature Methods | 2017 | 635 |
| 16 | T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development | Immunity | 2012 | 621 |
| 17 | Plasticity of Foxp3+ T Cells Reflects Promiscuous Foxp3 Expression in Conventional T Cells but Not Reprogramming of Regulatory T Cells | Immunity | 2012 | 534 |
| 18 | SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition | Nature Immunology | 2021 | 490 |
| 19 | Sequence and cultivation study of Muribaculaceae reveals novel species, host preference, and functional potential of this yet undescribed family | Microbiome | 2019 | 481 |
| 20 | Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013 | JAMA Pediatrics | 2016 | 479 |
| 21 | Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage? | Nature Reviews Immunology | 2009 | 468 |
| 22 | Neutrophils responsive to endogenous IFN-β regulate tumor angiogenesis and growth in a mouse tumor model | Journal of Clinical Investigation | 2010 | 456 |
| 23 | Complete genome sequence of DSM 30083T, the type strain (U5/41T) of Escherichia coli, and a proposal for delineating subspecies in microbial taxonomy | Standards in Genomic Sciences | 2014 | 454 |
| 24 | Targeting cardiac fibrosis with engineered T cells | Nature | 2019 | 404 |
| 25 | A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains | Genome Biology | 2013 | 403 |
| 26 | Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils | Nature Chemical Biology | 2012 | 400 |
| 27 | Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation | Nature Genetics | 2007 | 399 |
| 28 | Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss | Nature Communications | 2018 | 393 |
| 29 | Probiotic Escherichia coli Nissle 1917 Inhibits Leaky Gut by Enhancing Mucosal Integrity | PLoS ONE | 2007 | 386 |
| 30 | Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells | Journal of Allergy and Clinical Immunology | 2009 | 378 |
| 31 | Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation | Science Signaling | 2015 | 372 |
| 32 | DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection | Nature Medicine | 2007 | 371 |
| 33 | Regulation of antiviral T cell responses by type I interferons | Nature Reviews Immunology | 2015 | 371 |
| 34 | Metabolic pathways in T cell activation and lineage differentiation | Seminars in Immunology | 2016 | 361 |
| 35 | Therapeutic Strategies for Tendon Healing Based on Novel Biomaterials, Factors and Cells | Pathobiology | 2013 | 359 |
| 36 | Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke | Brain | 2011 | 346 |
| 37 | A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma | Cancer Cell | 2009 | 345 |
| 38 | Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation | Mucosal Immunology | 2016 | 341 |
| 39 | Uncovering the trimethylamine-producing bacteria of the human gut microbiota | Microbiome | 2017 | 336 |
| 40 | Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth | Nature Medicine | 2009 | 328 |
| 41 | Colonic Butyrate-Producing Communities in Humans: an Overview Using Omics Data | MSystems | 2017 | 328 |
| 42 | Climate influence on Vibrio and associated human diseases during the past half-century in the coastal North Atlantic | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 316 |
| 43 | Fungal diversity notes 367–490: taxonomic and phylogenetic contributions to fungal taxa | Fungal Diversity | 2016 | 314 |
| 44 | Genome-guided design of a defined mouse microbiota that confers colonization resistance against Salmonella enterica serovar Typhimurium | Nature Microbiology | 2017 | 313 |
| 45 | Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature | Blood | 2013 | 300 |
| 46 | Type IIFNs induce anti‐tumor polarization of tumor associated neutrophils in mice and human | International Journal of Cancer | 2016 | 298 |
| 47 | Nanoparticle Geometry and Surface Orientation Influence Mode of Cellular Uptake | ACS Nano | 2013 | 287 |
| 48 | Phylogenomics of Rhodobacteraceae reveals evolutionary adaptation to marine and non-marine habitats | ISME Journal | 2017 | 283 |
| 49 | Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments | Nature Communications | 2016 | 282 |
| 50 | Prevotella copriin individuals at risk for rheumatoid arthritis | Annals of the Rheumatic Diseases | 2019 | 279 |
