| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | The Pathogenesis of Rheumatoid Arthritis | New England Journal of Medicine | 2011 | 4,200 |
| 3 | Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial | Lancet, The | 2012 | 2,691 |
| 4 | DNA methylation-based classification of central nervous system tumours | Nature | 2018 | 1,872 |
| 5 | The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1 | Epilepsia | 2011 | 1,454 |
| 6 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 7 | Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy | Lancet Oncology, The | 2018 | 1,327 |
| 8 | Standardized surgery for colonic cancer: complete mesocolic excision and central ligation – technical notes and outcome | Colorectal Disease | 2009 | 1,233 |
| 9 | Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 1,201 |
| 10 | LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells | Cell Metabolism | 2016 | 1,126 |
| 11 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 12 | European Society of Contact Dermatitis guideline for diagnostic patch testing – recommendations on best practice | Contact Dermatitis | 2015 | 1,012 |
| 13 | Myocarditis in Patients Treated With Immune Checkpoint Inhibitors | Journal of the American College of Cardiology | 2018 | 997 |
| 14 | Large-scale genotyping identifies 41 new loci associated with breast cancer risk | Nature Genetics | 2013 | 960 |
| 15 | Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties | Cell | 2013 | 889 |
| 16 | STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing | Journal of Experimental Medicine | 2009 | 880 |
| 17 | International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods | Epilepsia | 2013 | 816 |
| 18 | Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) | European Journal of Immunology | 2019 | 766 |
| 19 | Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines | Nature Medicine | 2014 | 734 |
| 20 | Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes | American Journal of Human Genetics | 2019 | 711 |
| 21 | Consensus guidelines for the detection of immunogenic cell death | OncoImmunology | 2014 | 686 |
| 22 | Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016 | Modern Pathology | 2017 | 652 |
| 23 | Comparison of gene expression profiles between human and mouse monocyte subsets | Blood | 2010 | 609 |
| 24 | Catheter-based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED): a randomised, sham-controlled, proof-of-concept trial | Lancet, The | 2017 | 597 |
| 25 | 5-year results of accelerated partial breast irradiation using sole interstitial multicatheter brachytherapy versus whole-breast irradiation with boost after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: a randomised, phase 3, non-inferiority trial | Lancet, The | 2016 | 578 |
| 26 | Gastroenteropancreatic neuroendocrine neoplasms: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2020 | 571 |
| 27 | Transcription Factor E2-2 Is an Essential and Specific Regulator of Plasmacytoid Dendritic Cell Development | Cell | 2008 | 567 |
| 28 | The skin prick test – European standards | Clinical and Translational Allergy | 2013 | 562 |
| 29 | Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche | Nature | 2014 | 548 |
| 30 | Patient selection for accelerated partial-breast irradiation (APBI) after breast-conserving surgery: Recommendations of the Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) breast cancer working group based on clinical evidence (2009) | Radiotherapy and Oncology | 2010 | 546 |
| 31 | Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy | European Journal of Cancer | 2016 | 546 |
| 32 | The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis | Nature Medicine | 2008 | 535 |
| 33 | Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO): a multicentre, international, single-blind, randomised, sham-controlled trial | Lancet, The | 2018 | 526 |
| 34 | Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy | JAMA - Journal of the American Medical Association | 2015 | 523 |
| 35 | Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer | Nature Genetics | 2015 | 513 |
| 36 | Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer | Cell Death and Differentiation | 2016 | 506 |
| 37 | Guidelines for the use of flow cytometry and cell sorting in immunological studies* | European Journal of Immunology | 2017 | 505 |
| 38 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer | Nature Genetics | 2013 | 493 |
| 39 | Neurological, respiratory, musculoskeletal, cardiac and ocular side-effects of anti-PD-1 therapy | European Journal of Cancer | 2016 | 490 |
| 40 | Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma | Cancer Cell | 2016 | 486 |
| 41 | Overall Survival with Ribociclib plus Fulvestrant in Advanced Breast Cancer | New England Journal of Medicine | 2020 | 482 |
| 42 | Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab | Clinical Cancer Research | 2016 | 480 |
| 43 | Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE | Journal of Experimental Medicine | 2008 | 467 |
| 44 | Technology in Parkinson's disease: Challenges and opportunities | Movement Disorders | 2016 | 464 |
| 45 | A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis | Nature Genetics | 2015 | 435 |
| 46 | Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk | Nature Genetics | 2017 | 426 |
| 47 | Lapatinib versus trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy (GeparQuinto, GBG 44): a randomised phase 3 trial | Lancet Oncology, The | 2012 | 425 |
| 48 | Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the future | Cancer Treatment Reviews | 2015 | 414 |
| 49 | The Price of Tumor Control: An Analysis of Rare Side Effects of Anti-CTLA-4 Therapy in Metastatic Melanoma from the Ipilimumab Network | PLoS ONE | 2013 | 414 |
| 50 | Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy | PLoS ONE | 2016 | 413 |
