| # | Title | Journal | Year | Citations |
|---|
| 1 | The Sequence of the Human Genome | Science | 2001 | 12,623 |
| 2 | Design and validation of a histological scoring system for nonalcoholic fatty liver disease | Hepatology | 2005 | 8,518 |
| 3 | The number of people with glaucoma worldwide in 2010 and 2020 | British Journal of Ophthalmology | 2006 | 5,850 |
| 4 | Postoperative pancreatic fistula: An international study group (ISGPF) definition | Surgery | 2005 | 3,894 |
| 5 | Global Prevalence and Major Risk Factors of Diabetic Retinopathy | Diabetes Care | 2012 | 3,439 |
| 6 | Clues to the pathogenesis of familial colorectal cancer | Science | 1993 | 2,563 |
| 7 | Ectopic Ossification Following Total Hip Replacement | Journal of Bone and Joint Surgery - Series A | 1973 | 2,549 |
| 8 | The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma | American Journal of Surgical Pathology | 2005 | 2,334 |
| 9 | Cell cycle control and cancer | Science | 1994 | 2,234 |
| 10 | The Development of Human Benign Prostatic Hyperplasia with Age | Journal of Urology | 1984 | 2,145 |
| 11 | Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU | Critical Care Medicine | 2018 | 2,074 |
| 12 | The SCL-90 and the MMPI: A Step in the Validation of a New Self-Report Scale | British Journal of Psychiatry | 1976 | 1,975 |
| 13 | Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival | Cancer Cell | 2014 | 1,892 |
| 14 | Reversal of experimental parkinsonism by lesions of the subthalamic nucleus | Science | 1990 | 1,845 |
| 15 | Spontaneous Intracerebral Hemorrhage | New England Journal of Medicine | 2001 | 1,509 |
| 16 | The New WHO Classification of Brain Tumours | Brain Pathology | 1993 | 1,480 |
| 17 | Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis | Cancer Research | 1993 | 1,427 |
| 18 | Trends in Long-Term Survival Following Liver Resection for Hepatic Colorectal Metastases | Annals of Surgery | 2002 | 1,305 |
| 19 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity | Gastrointestinal Endoscopy | 2004 | 1,287 |
| 20 | HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Personnel, Policy, Procedures and Follow-Up | Heart Rhythm | 2007 | 1,258 |
| 21 | International evidence-based recommendations on ultrasound-guided vascular access | Intensive Care Medicine | 2012 | 1,199 |
| 22 | 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design | Journal of Interventional Cardiac Electrophysiology | 2012 | 1,167 |
| 23 | The Use of Prostate Specific Antigen, Clinical Stage and Gleason Score to Predict Pathological Stage in Men with Localized Prostate Cancer | Journal of Urology | 1993 | 1,152 |
| 24 | Comparison of 1,800 Laparoscopic and Open Partial Nephrectomies for Single Renal Tumors | Journal of Urology | 2007 | 1,101 |
| 25 | Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS | Neuron | 2010 | 1,100 |
| 26 | Pancreatic Intraepithelial Neoplasia | American Journal of Surgical Pathology | 2001 | 1,051 |
| 27 | Diagnosis and management of primary sclerosing cholangitis | Hepatology | 2010 | 1,048 |
| 28 | Vascular Anomalies Classification: Recommendations From the International Society for the Study of Vascular Anomalies | Pediatrics | 2015 | 1,026 |
| 29 | Mental and Behavioral Disturbances in Dementia: Findings From the Cache County Study on Memory in Aging | American Journal of Psychiatry | 2000 | 1,025 |
| 30 | Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome | Nature Genetics | 1997 | 1,018 |
| 31 | HIF-1 and mechanisms of hypoxia sensing | Current Opinion in Cell Biology | 2001 | 1,008 |
| 32 | Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 1,008 |
| 33 | Radical prostatectomy with preservation of sexual function: Anatomical and pathological considerations | Prostate | 1983 | 974 |
| 34 | Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster | Nature | 1982 | 963 |
| 35 | Tricuspid Annular Displacement Predicts Survival in Pulmonary Hypertension | American Journal of Respiratory and Critical Care Medicine | 2006 | 955 |
| 36 | Genetic progression model for head and neck cancer: implications for field cancerization | Cancer Research | 1996 | 928 |
| 37 | Transcatheter Aortic Valve Replacement Using a Self-Expanding Bioprosthesis in Patients With Severe Aortic Stenosis at Extreme Risk for Surgery | Journal of the American College of Cardiology | 2014 | 902 |
| 38 | Epidemiology of Human Papillomavirus–Positive Head and Neck Squamous Cell Carcinoma | Journal of Clinical Oncology | 2015 | 873 |
| 39 | Prevalence of Open-Angle Glaucoma Among Adults in the United States | JAMA Ophthalmology | 2004 | 869 |
| 40 | Adverse Clinical and Economic Outcomes Attributable to Methicillin Resistance among Patients withStaphylococcus aureusSurgical Site Infection | Clinical Infectious Diseases | 2003 | 860 |
| 41 | Genetic mapping of a locus predisposing to human colorectal cancer | Science | 1993 | 846 |
| 42 | Bilateral Orchiectomy with or without Flutamide for Metastatic Prostate Cancer | New England Journal of Medicine | 1998 | 839 |
| 43 | Right ventricular failure in patients with the HeartMate II continuous-flow left ventricular assist device: Incidence, risk factors, and effect on outcomes | Journal of Thoracic and Cardiovascular Surgery | 2010 | 837 |
| 44 | Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology | Trends in Molecular Medicine | 2001 | 830 |
| 45 | Extended Mechanical Circulatory Support With a Continuous-Flow Rotary Left Ventricular Assist Device | Journal of the American College of Cardiology | 2009 | 825 |
| 46 | Long-Term Outcome of Fulminant Myocarditis as Compared with Acute (Nonfulminant) Myocarditis | New England Journal of Medicine | 2000 | 811 |
| 47 | Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma | JAMA Oncology | 2020 | 805 |
| 48 | Radiographical Spinopelvic Parameters and Disability in the Setting of Adult Spinal Deformity | Spine | 2013 | 802 |
| 49 | Prostate cancer | Lancet, The | 2016 | 801 |
| 50 | Clinical management of continuous-flow left ventricular assist devices in advanced heart failure | Journal of Heart and Lung Transplantation | 2010 | 798 |
