| # | Title | Journal | Year | Citations |
|---|
| 1 | Improved Survival with Ipilimumab in Patients with Metastatic Melanoma | New England Journal of Medicine | 2010 | 13,065 |
| 2 | Surviving Sepsis Campaign | Critical Care Medicine | 2013 | 6,362 |
| 3 | Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer | Thyroid | 2009 | 6,039 |
| 4 | The metabolic syndrome | Lancet, The | 2005 | 5,212 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 6 | The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure | New England Journal of Medicine | 1996 | 4,294 |
| 7 | Neuroinflammation in Alzheimer's disease | Lancet Neurology, The | 2015 | 4,129 |
| 8 | Biological properties of extracellular vesicles and their physiological functions | Journal of Extracellular Vesicles | 2015 | 3,973 |
| 9 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 10 | Survival in Patients with Primary Pulmonary Hypertension | Annals of Internal Medicine | 1991 | 3,050 |
| 11 | Immunological and Inflammatory Functions of the Interleukin-1 Family | Annual Review of Immunology | 2009 | 2,831 |
| 12 | Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014 | MMWR Surveillance Summaries | 2018 | 2,687 |
| 13 | A Comparison of Continuous Intravenous Epoprostenol (Prostacyclin) with Conventional Therapy for Primary Pulmonary Hypertension | New England Journal of Medicine | 1996 | 2,529 |
| 14 | Age-predicted maximal heart rate revisited | Journal of the American College of Cardiology | 2001 | 2,517 |
| 15 | Fools Rush in? The Institutional Context of Industry Creation | Academy of Management Review | 1994 | 2,480 |
| 16 | Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis | Annals of Neurology | 1996 | 2,365 |
| 17 | Ranibizumab and Bevacizumab for Neovascular Age-Related Macular Degeneration | New England Journal of Medicine | 2011 | 2,355 |
| 18 | Peripheral Arterial Disease Detection, Awareness, and Treatment in Primary Care | JAMA - Journal of the American Medical Association | 2001 | 2,332 |
| 19 | Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes | New England Journal of Medicine | 2013 | 2,294 |
| 20 | Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice | Science | 2005 | 2,181 |
| 21 | Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council | Journal of Pain | 2016 | 2,040 |
| 22 | The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia | New England Journal of Medicine | 2003 | 1,780 |
| 23 | Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV Melanoma | New England Journal of Medicine | 2017 | 1,752 |
| 24 | Customer Switching Behavior in Service Industries: An Exploratory Study | Journal of Marketing | 1995 | 1,723 |
| 25 | 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative | Annals of the Rheumatic Diseases | 2013 | 1,705 |
| 26 | Hypoxia and Inflammation | New England Journal of Medicine | 2011 | 1,692 |
| 27 | Prophylaxis versus Episodic Treatment to Prevent Joint Disease in Boys with Severe Hemophilia | New England Journal of Medicine | 2007 | 1,681 |
| 28 | The Spectrum of Engagement in HIV Care and its Relevance to Test-and-Treat Strategies for Prevention of HIV Infection | Clinical Infectious Diseases | 2011 | 1,677 |
| 29 | Revision of the CEAP classification for chronic venous disorders: Consensus statement | Journal of Vascular Surgery | 2004 | 1,627 |
| 30 | “Economic man” in cross-cultural perspective: Behavioral experiments in 15 small-scale societies | Behavioral and Brain Sciences | 2005 | 1,625 |
| 31 | Nephrectomy Followed by Interferon Alfa-2b Compared with Interferon Alfa-2b Alone for Metastatic Renal-Cell Cancer | New England Journal of Medicine | 2001 | 1,583 |
| 32 | Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma | Cancer Cell | 2012 | 1,551 |
| 33 | Customer Switching Behavior in Service Industries: An Exploratory Study | Journal of Marketing | 1995 | 1,534 |
| 34 | The Metabolic Syndrome | Endocrine Reviews | 2008 | 1,513 |
| 35 | Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases | Nature Reviews Drug Discovery | 2012 | 1,479 |
| 36 | Costly Punishment Across Human Societies | Science | 2006 | 1,445 |
| 37 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 38 | Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial | Lancet Oncology, The | 2015 | 1,419 |
| 39 | Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes: One-year results of the Look AHEAD trial | Diabetes Care | 2007 | 1,369 |
| 40 | Continuous Glucose Monitoring and Intensive Treatment of Type 1 Diabetes | New England Journal of Medicine | 2008 | 1,369 |
| 41 | Ceritinib inALK-Rearranged Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2014 | 1,367 |
| 42 | Is Anybody out There? Antecedents of Trust in Global Virtual Teams | Journal of Management Information Systems | 1998 | 1,362 |
| 43 | A Randomized Trial of Aspirin to Prevent Colorectal Adenomas | New England Journal of Medicine | 2003 | 1,358 |
| 44 | Predicting Survival in Pulmonary Arterial Hypertension | Circulation | 2010 | 1,353 |
| 45 | State of Type 1 Diabetes Management and Outcomes from the T1D Exchange in 2016–2018 | Diabetes Technology and Therapeutics | 2019 | 1,332 |
| 46 | Cellular and molecular pathobiology of pulmonary arterial hypertension | Journal of the American College of Cardiology | 2004 | 1,322 |
| 47 | Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2012 | MMWR Surveillance Summaries | 2016 | 1,306 |
| 48 | Update of the LIPID MAPS comprehensive classification system for lipids | Journal of Lipid Research | 2009 | 1,300 |
| 49 | Evolutionary and Biomedical Insights from the Rhesus Macaque Genome | Science | 2007 | 1,283 |
| 50 | Identification of a Gene That Causes Primary Open Angle Glaucoma | Science | 1997 | 1,274 |
