| # | Title | Journal | Year | Citations |
|---|
| 1 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 9,122 |
| 2 | “Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A | Analytical Biochemistry | 1981 | 8,736 |
| 3 | Circulating microRNAs as stable blood-based markers for cancer detection | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 7,047 |
| 4 | Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein | Cell | 2020 | 6,979 |
| 5 | Integrated analysis of multimodal single-cell data | Cell | 2021 | 5,912 |
| 6 | Amino acid substitution matrices from protein blocks. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 5,230 |
| 7 | SIFT: predicting amino acid changes that affect protein function | Nucleic Acids Research | 2003 | 5,120 |
| 8 | Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing | Gene | 1984 | 4,616 |
| 9 | Massively parallel digital transcriptional profiling of single cells | Nature Communications | 2017 | 4,535 |
| 10 | Generalized lacZ expression with the ROSA26 Cre reporter strain | Nature Genetics | 1999 | 4,530 |
| 11 | Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel | Blood | 2017 | 4,375 |
| 12 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015 | JAMA Oncology | 2017 | 4,254 |
| 13 | Effects of Conjugated Equine Estrogen in Postmenopausal Women With Hysterectomy | JAMA - Journal of the American Medical Association | 2004 | 3,881 |
| 14 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 15 | Tumour exosome integrins determine organotropic metastasis | Nature | 2015 | 3,688 |
| 16 | A SARS-CoV-2 protein interaction map reveals targets for drug repurposing | Nature | 2020 | 3,542 |
| 17 | Effects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular Disease | New England Journal of Medicine | 1996 | 3,358 |
| 18 | Software for Computing and Annotating Genomic Ranges | PLoS Computational Biology | 2013 | 3,262 |
| 19 | Systematic Localization of Common Disease-Associated Variation in Regulatory DNA | Science | 2012 | 3,129 |
| 20 | From molecular to modular cell biology | Nature | 1999 | 3,121 |
| 21 | Nomenclature for factors of the HLA system, 2010 | Tissue Antigens | 2010 | 3,121 |
| 22 | Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex | Nature | 1998 | 3,102 |
| 23 | Orchestrating high-throughput genomic analysis with Bioconductor | Nature Methods | 2015 | 3,070 |
| 24 | Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor | PLoS Biology | 2008 | 3,067 |
| 25 | Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet | Blood | 2010 | 2,963 |
| 26 | Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 2,852 |
| 27 | The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak | Science | 2020 | 2,784 |
| 28 | Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates | Molecular Cell | 2013 | 2,734 |
| 29 | Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA | Science | 1999 | 2,677 |
| 30 | National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report | Biology of Blood and Marrow Transplantation | 2015 | 2,636 |
| 31 | The accessible chromatin landscape of the human genome | Nature | 2012 | 2,434 |
| 32 | Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT | Blood | 2005 | 2,427 |
| 33 | A reference panel of 64,976 haplotypes for genotype imputation | Nature Genetics | 2016 | 2,421 |
| 34 | Functional Discovery via a Compendium of Expression Profiles | Cell | 2000 | 2,412 |
| 35 | Estimation of failure probabilities in the presence of competing risks: new representations of old estimators | Cell | 1999 | 2,407 |
| 36 | Nextstrain: real-time tracking of pathogen evolution | Bioinformatics | 2018 | 2,287 |
| 37 | The protein Id: A negative regulator of helix-loop-helix DNA binding proteins | Cell | 1990 | 2,214 |
| 38 | Time-Dependent ROC Curves for Censored Survival Data and a Diagnostic Marker | Biometrics | 2000 | 2,211 |
| 39 | Predicting Deleterious Amino Acid Substitutions | Genome Research | 2001 | 2,186 |
| 40 | Prediction of central nervous system embryonal tumour outcome based on gene expression | Nature | 2002 | 2,154 |
| 41 | Asymptotic Properties of Maximum Likelihood Estimators and Likelihood Ratio Tests under Nonstandard Conditions | Journal of the American Statistical Association | 1987 | 2,151 |
| 42 | Oncogenic Signaling Pathways in The Cancer Genome Atlas | Cell | 2018 | 2,111 |
| 43 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | Nature Genetics | 2015 | 2,054 |
| 44 | MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data | Genome Biology | 2015 | 2,047 |
| 45 | Mammalian Ras interacts directly with the serine/threonine kinase raf | Cell | 1993 | 2,015 |
| 46 | A framework for advancing our understanding of cancer-associated fibroblasts | Nature Reviews Cancer | 2020 | 2,012 |
| 47 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 48 | Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer | Science | 2009 | 1,955 |
| 49 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 50 | Estimation of Regression Coefficients When Some Regressors are not Always Observed | Journal of the American Statistical Association | 1994 | 1,811 |
