| # | Title | Journal | Year | Citations |
|---|
| 1 | Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy | JAMA - Journal of the American Medical Association | 2020 | 4,411 |
| 2 | Clinical Management of Hepatocellular Carcinoma. Conclusions of the Barcelona-2000 EASL Conference | Journal of Hepatology | 2001 | 3,959 |
| 3 | Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. | Circulation Research | 1986 | 3,777 |
| 4 | A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement | Journal of Hepatology | 2020 | 2,171 |
| 5 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 6 | Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: A multiple-center epidemiological study* | Critical Care Medicine | 2005 | 1,885 |
| 7 | Moderate and severe traumatic brain injury in adults | Lancet Neurology, The | 2008 | 1,715 |
| 8 | Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease | Nature Genetics | 2011 | 1,685 |
| 9 | Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia | New England Journal of Medicine | 2017 | 1,462 |
| 10 | Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data | BMJ: British Medical Journal | 2017 | 1,408 |
| 11 | 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus | Annals of the Rheumatic Diseases | 2019 | 1,265 |
| 12 | Endometriosis: pathogenesis and treatment | Nature Reviews Endocrinology | 2014 | 1,233 |
| 13 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms | Leukemia | 2022 | 1,211 |
| 14 | Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study | Intensive Care Medicine | 2004 | 1,188 |
| 15 | Effect of Prone Positioning on the Survival of Patients with Acute Respiratory Failure | New England Journal of Medicine | 2001 | 1,184 |
| 16 | Risk Factors Associated With Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy | JAMA Internal Medicine | 2020 | 1,165 |
| 17 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms | Leukemia | 2022 | 1,023 |
| 18 | Albumin Replacement in Patients with Severe Sepsis or Septic Shock | New England Journal of Medicine | 2014 | 947 |
| 19 | Efficacy of a Tyrosine Kinase Inhibitor in Idiopathic Pulmonary Fibrosis | New England Journal of Medicine | 2011 | 930 |
| 20 | Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift | Nature | 2022 | 917 |
| 21 | Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells | Nature Cell Biology | 2007 | 899 |
| 22 | Joint European League Against Rheumatism and European Renal Association–European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis | Annals of the Rheumatic Diseases | 2012 | 868 |
| 23 | Hepatocellular Carcinoma in Italian Patients with Cirrhosis | New England Journal of Medicine | 1991 | 773 |
| 24 | Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) | European Journal of Immunology | 2019 | 766 |
| 25 | The 2016 European Thyroid Association/European Group on Graves' Orbitopathy Guidelines for the Management of Graves' Orbitopathy | European Thyroid Journal | 2016 | 738 |
| 26 | Updated Analysis From KEYNOTE-189: Pembrolizumab or Placebo Plus Pemetrexed and Platinum for Previously Untreated Metastatic Nonsquamous Non–Small-Cell Lung Cancer | Journal of Clinical Oncology | 2020 | 710 |
| 27 | What Has Computed Tomography Taught Us about the Acute Respiratory Distress Syndrome? | American Journal of Respiratory and Critical Care Medicine | 2001 | 706 |
| 28 | Tidal Hyperinflation during Low Tidal Volume Ventilation in Acute Respiratory Distress Syndrome | American Journal of Respiratory and Critical Care Medicine | 2007 | 699 |
| 29 | First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial | Lancet, The | 2021 | 638 |
| 30 | Lung Stress and Strain during Mechanical Ventilation for Acute Respiratory Distress Syndrome | American Journal of Respiratory and Critical Care Medicine | 2008 | 633 |
| 31 | Rapid DNA Methylation Changes after Exposure to Traffic Particles | American Journal of Respiratory and Critical Care Medicine | 2009 | 608 |
| 32 | Elective caesarean-section versus vaginal delivery in prevention of vertical HIV-1 transmission: a randomised clinical trial | Lancet, The | 1999 | 607 |
| 33 | Relationships Between Lung Computed Tomographic Density, Gas Exchange, and PEEP in Acute Respiratory Failure | Anesthesiology | 1988 | 596 |
| 34 | Advances in heart rate variability signal analysis: joint position statement by the e-Cardiology ESC Working Group and the European Heart Rhythm Association co-endorsed by the Asia Pacific Heart Rhythm Society | Europace | 2015 | 589 |
| 35 | Factors Influencing Children’s Eating Behaviours | Nutrients | 2018 | 588 |
| 36 | Chest electrical impedance tomography examination, data analysis, terminology, clinical use and recommendations: consensus statement of the TRanslational EIT developmeNt stuDy group | Thorax | 2017 | 580 |
| 37 | Rivaroxaban vs warfarin in high-risk patients with antiphospholipid syndrome | Blood | 2018 | 573 |
| 38 | Low-Frequency Positive-Pressure Ventilation With Extracorporeal CO2 Removal in Severe Acute Respiratory Failure | JAMA - Journal of the American Medical Association | 1986 | 558 |
| 39 | Randomized Study of Adjuvant Chemotherapy for Completely Resected Stage I, II, or IIIA Non-Small-Cell Lung Cancer | Journal of the National Cancer Institute | 2003 | 550 |
| 40 | The Frontal Assessment Battery (FAB): normative values in an Italian population sample | Neurological Sciences | 2005 | 550 |
| 41 | Effects of positive end-expiratory pressure on regional distribution of tidal volume and recruitment in adult respiratory distress syndrome. | American Journal of Respiratory and Critical Care Medicine | 1995 | 545 |
| 42 | Aspirin for Preventing the Recurrence of Venous Thromboembolism | New England Journal of Medicine | 2012 | 545 |
| 43 | Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta‐analysis | Journal of Gastroenterology and Hepatology (Australia) | 2016 | 537 |
| 44 | APOE and Alzheimer disease: a major gene with semi-dominant inheritance | Molecular Psychiatry | 2011 | 529 |
| 45 | ESCMID guideline: diagnosis and treatment of acute bacterial meningitis | Clinical Microbiology and Infection | 2016 | 529 |
| 46 | Fertility and ageing | Human Reproduction Update | 2005 | 520 |
| 47 | Subcutaneous and visceral fat distribution according to sex, age, and overweight, evaluated by computed tomography | American Journal of Clinical Nutrition | 1986 | 517 |
| 48 | Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study | Lancet Respiratory Medicine,the | 2020 | 516 |
| 49 | Systematic approach to sonographic evaluation of the pelvis in women with suspected endometriosis, including terms, definitions and measurements: a consensus opinion from the International Deep Endometriosis Analysis (IDEA) group | Ultrasound in Obstetrics and Gynecology | 2016 | 503 |
| 50 | COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study | Lancet Oncology, The | 2020 | 503 |
