| # | Title | Journal | Year | Citations |
|---|
| 1 | The Reactome pathway Knowledgebase | Nucleic Acids Research | 2016 | 3,319 |
| 2 | The Reactome Pathway Knowledgebase | Nucleic Acids Research | 2018 | 2,388 |
| 3 | Tumour evolution inferred by single-cell sequencing | Nature | 2011 | 2,313 |
| 4 | VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R | BMC Bioinformatics | 2011 | 2,018 |
| 5 | Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes | Nature | 2012 | 1,741 |
| 6 | ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia | Genome Research | 2012 | 1,708 |
| 7 | Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis | Nature Genetics | 2010 | 1,631 |
| 8 | The reactome pathway knowledgebase | Nucleic Acids Research | 2020 | 1,570 |
| 9 | Nanopore sequencing and assembly of a human genome with ultra-long reads | Nature Biotechnology | 2018 | 1,443 |
| 10 | Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray | Epigenetics | 2013 | 1,276 |
| 11 | Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia | Nature | 2014 | 1,241 |
| 12 | Shotgun metagenomics, from sampling to analysis | Nature Biotechnology | 2017 | 1,196 |
| 13 | Real-time, portable genome sequencing for Ebola surveillance | Nature | 2016 | 1,179 |
| 14 | A complete bacterial genome assembled de novo using only nanopore sequencing data | Nature Methods | 2015 | 1,176 |
| 15 | Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap | Nature Protocols | 2019 | 1,172 |
| 16 | Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE | Science | 2010 | 1,124 |
| 17 | Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Update | Archives of Pathology and Laboratory Medicine | 2014 | 961 |
| 18 | The reactome pathway knowledgebase 2022 | Nucleic Acids Research | 2022 | 924 |
| 19 | Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project | Science | 2010 | 912 |
| 20 | Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples | Nature Protocols | 2017 | 898 |
| 21 | Copy number variation and selection during reprogramming to pluripotency | Nature | 2011 | 870 |
| 22 | The Systems Biology Graphical Notation | Nature Biotechnology | 2009 | 828 |
| 23 | Detecting DNA cytosine methylation using nanopore sequencing | Nature Methods | 2017 | 820 |
| 24 | Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles | Journal of Controlled Release | 2013 | 784 |
| 25 | A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance | Nature Genetics | 2012 | 762 |
| 26 | GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment | Science | 2013 | 750 |
| 27 | BioMart – biological queries made easy | BMC Genomics | 2009 | 738 |
| 28 | Response assessment criteria for brain metastases: proposal from the RANO group | Lancet Oncology, The | 2015 | 711 |
| 29 | New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs | Cell | 2016 | 702 |
| 30 | Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer | Science | 2013 | 691 |
| 31 | The BioMart community portal: an innovative alternative to large, centralized data repositories | Nucleic Acids Research | 2015 | 682 |
| 32 | Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer | Cancer Discovery | 2018 | 676 |
| 33 | Functional normalization of 450k methylation array data improves replication in large cancer studies | Genome Biology | 2014 | 665 |
| 34 | Design and methods of the Population Assessment of Tobacco and Health (PATH) Study | Tobacco Control | 2017 | 642 |
| 35 | Sensitive tumour detection and classification using plasma cell-free DNA methylomes | Nature | 2018 | 624 |
| 36 | Pathogenic Germline Variants in 10,389 Adult Cancers | Cell | 2018 | 620 |
| 37 | Prediction of acute myeloid leukaemia risk in healthy individuals | Nature | 2018 | 617 |
| 38 | The BioPAX community standard for pathway data sharing | Nature Biotechnology | 2010 | 613 |
| 39 | Reactome pathway analysis: a high-performance in-memory approach | BMC Bioinformatics | 2017 | 600 |
| 40 | A human functional protein interaction network and its application to cancer data analysis | Genome Biology | 2010 | 591 |
| 41 | Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression | Nature Genetics | 2021 | 590 |
| 42 | Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture | Nature Genetics | 2013 | 578 |
| 43 | Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons | Sleep | 2013 | 545 |
| 44 | International Cancer Genome Consortium Data Portal--a one-stop shop for cancer genomics data | Database: the Journal of Biological Databases and Curation | 2011 | 520 |
| 45 | Establishment and cryptic transmission of Zika virus in Brazil and the Americas | Nature | 2017 | 515 |
| 46 | Molecular landmarks of tumor hypoxia across cancer types | Nature Genetics | 2019 | 480 |
| 47 | Stealth nanoparticles: High density but sheddable PEG is a key for tumor targeting | Journal of Controlled Release | 2010 | 475 |
| 48 | Genomic hallmarks of localized, non-indolent prostate cancer | Nature | 2017 | 462 |
| 49 | Common variants in the NLRP3 region contribute to Crohn's disease susceptibility | Nature Genetics | 2009 | 448 |
| 50 | The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies | BMC Endocrine Disorders | 2014 | 440 |
