| # | Title | Journal | Year | Citations |
|---|
| 1 | Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines | Immunity | 2014 | 4,638 |
| 2 | Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial | Lancet, The | 2017 | 3,872 |
| 3 | Twenty-Year Follow-up of a Randomized Study Comparing Breast-Conserving Surgery with Radical Mastectomy for Early Breast Cancer | New England Journal of Medicine | 2002 | 3,765 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 5 | Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013 | Annals of Oncology | 2013 | 2,805 |
| 6 | Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium | International Journal of Gynecology and Obstetrics | 2009 | 2,331 |
| 7 | The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014 | Annals of Oncology | 2015 | 2,122 |
| 8 | Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer | Nature Reviews Cancer | 2006 | 2,049 |
| 9 | A Randomized Comparison of Sentinel-Node Biopsy with Routine Axillary Dissection in Breast Cancer | New England Journal of Medicine | 2003 | 1,960 |
| 10 | The spindle-assembly checkpoint in space and time | Nature Reviews Molecular Cell Biology | 2007 | 1,932 |
| 11 | Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes | Lancet, The | 1997 | 1,872 |
| 12 | Trained immunity: A program of innate immune memory in health and disease | Science | 2016 | 1,809 |
| 13 | The p66shc adaptor protein controls oxidative stress response and life span in mammals | Nature | 1999 | 1,619 |
| 14 | Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells | EMBO Journal | 2001 | 1,607 |
| 15 | Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication | Nature | 2006 | 1,576 |
| 16 | Tailoring therapies—improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015 | Annals of Oncology | 2015 | 1,449 |
| 17 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 18 | Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trial | Lancet Oncology, The | 2016 | 1,344 |
| 19 | International evidence-based recommendations on ultrasound-guided vascular access | Intensive Care Medicine | 2012 | 1,199 |
| 20 | Prolonged Survival in Stage III Melanoma with Ipilimumab Adjuvant Therapy | New England Journal of Medicine | 2016 | 1,140 |
| 21 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 22 | Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial | Lancet Oncology, The | 2015 | 1,093 |
| 23 | Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067): 4-year outcomes of a multicentre, randomised, phase 3 trial | Lancet Oncology, The | 2018 | 1,089 |
| 24 | EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer | EMBO Journal | 2003 | 1,052 |
| 25 | Expert Consensus for Multimodality Imaging Evaluation of Adult Patients during and after Cancer Therapy: A Report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging | Journal of the American Society of Echocardiography | 2014 | 1,051 |
| 26 | Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis | Cell | 2005 | 1,041 |
| 27 | Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors | Nature Biotechnology | 2008 | 1,030 |
| 28 | Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure | European Journal of Cancer | 2005 | 1,024 |
| 29 | Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia | Nature | 1998 | 1,015 |
| 30 | Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23–01): a phase 3 randomised controlled trial | Lancet Oncology, The | 2013 | 998 |
| 31 | Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas | Nature Medicine | 1997 | 967 |
| 32 | Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled, phase 3 study | Lancet, The | 2016 | 962 |
| 33 | Large-scale genotyping identifies 41 new loci associated with breast cancer risk | Nature Genetics | 2013 | 960 |
| 34 | Carcinoma of the Ovary | International Journal of Gynecology and Obstetrics | 2006 | 950 |
| 35 | Anthracycline-Induced Cardiomyopathy | Journal of the American College of Cardiology | 2010 | 949 |
| 36 | Overview of the main outcomes in breast-cancer prevention trials | Lancet, The | 2003 | 918 |
| 37 | Hereditary Pancreatitis and the Risk of Pancreatic Cancer | Journal of the National Cancer Institute | 1997 | 905 |
| 38 | Safety and efficacy of vemurafenib in BRAFV600E and BRAFV600K mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study | Lancet Oncology, The | 2014 | 890 |
| 39 | Alcohol consumption and site-specific cancer risk: a comprehensive dose–response meta-analysis | British Journal of Cancer | 2015 | 880 |
| 40 | Prevention of High-Dose Chemotherapy–Induced Cardiotoxicity in High-Risk Patients by Angiotensin-Converting Enzyme Inhibition | Circulation | 2006 | 875 |
| 41 | 3rd ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 3) | Annals of Oncology | 2017 | 865 |
| 42 | ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma | International Journal of Gynecological Cancer | 2021 | 859 |
| 43 | Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content | Cell | 2010 | 847 |
| 44 | De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017 | Annals of Oncology | 2017 | 844 |
| 45 | Prognostic Value of Troponin I in Cardiac Risk Stratification of Cancer Patients Undergoing High-Dose Chemotherapy | Circulation | 2004 | 797 |
| 46 | Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity | EMBO Journal | 2004 | 778 |
| 47 | Cancer in patients on dialysis for end-stage renal disease: an international collaborative study | Lancet, The | 1999 | 773 |
| 48 | 11 years' follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive early breast cancer: final analysis of the HERceptin Adjuvant (HERA) trial | Lancet, The | 2017 | 770 |
| 49 | Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence | EMBO Journal | 2002 | 764 |
| 50 | PML regulates p53 acetylation and premature senescence induced by oncogenic Ras | Nature | 2000 | 761 |
