| # | Title | Journal | Year | Citations |
|---|
| 1 | The Fluid Mosaic Model of the Structure of Cell Membranes | Science | 1972 | 8,318 |
| 2 | An Information-Maximization Approach to Blind Separation and Blind Deconvolution | Neural Computation | 1995 | 7,791 |
| 3 | The steroid and thyroid hormone receptor superfamily | Science | 1988 | 7,368 |
| 4 | The Protein Kinase Complement of the Human Genome | Science | 2002 | 7,123 |
| 5 | The Genome Sequence of Drosophila melanogaster | Science | 2000 | 5,566 |
| 6 | The protein kinase family: conserved features and deduced phylogeny of the catalytic domains | Science | 1988 | 5,015 |
| 7 | In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector | Science | 1996 | 4,589 |
| 8 | Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin | Science | 1981 | 4,243 |
| 9 | Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects | Nature Neuroscience | 1999 | 4,034 |
| 10 | Cloned Glutamate Receptors | Annual Review of Neuroscience | 1994 | 3,813 |
| 11 | Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone | Science | 1973 | 3,432 |
| 12 | Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus | Nature Neuroscience | 1999 | 3,370 |
| 13 | AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint | Molecular Cell | 2008 | 3,147 |
| 14 | Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling | Cell | 1995 | 2,868 |
| 15 | Mechanisms Underlying Inflammation in Neurodegeneration | Cell | 2010 | 2,860 |
| 16 | Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation | Journal of Neuroscience | 1996 | 2,844 |
| 17 | 15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ | Cell | 1995 | 2,811 |
| 18 | Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking | Nature Biotechnology | 2016 | 2,802 |
| 19 | Mechanisms and Functional Implications of Adult Neurogenesis | Cell | 2008 | 2,678 |
| 20 | H2O2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response | Cell | 1994 | 2,602 |
| 21 | Suppression of TNF-alpha -Induced Apoptosis by NF-kappa B | Science | 1996 | 2,565 |
| 22 | Running enhances neurogenesis, learning, and long-term potentiation in mice | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 2,499 |
| 23 | Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133 | Cell | 1989 | 2,462 |
| 24 | Face recognition by elastic bunch graph matching | IEEE Transactions on Pattern Analysis and Machine Intelligence | 1997 | 2,408 |
| 25 | The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions | Science | 2007 | 2,354 |
| 26 | A gene expression map of Arabidopsis thaliana development | Nature Genetics | 2005 | 2,293 |
| 27 | Transcriptional regulation by the phosphorylation-dependent factor CREB | Nature Reviews Molecular Cell Biology | 2001 | 2,257 |
| 28 | Neural consequences of enviromental enrichment | Nature Reviews Neuroscience | 2000 | 2,147 |
| 29 | Hydrogen peroxide mediates amyloid β protein toxicity | Cell | 1994 | 2,136 |
| 30 | Cyclins and cancer II: Cyclin D and CDK inhibitors come of age | Cell | 1994 | 2,113 |
| 31 | Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy | Science | 2011 | 2,107 |
| 32 | Adapting Proteostasis for Disease Intervention | Science | 2008 | 2,104 |
| 33 | The three-dimensional organization of the hippocampal formation: A review of anatomical data | Neuroscience | 1989 | 2,090 |
| 34 | Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: An in situ hybridization study | Journal of Comparative Neurology | 1990 | 2,020 |
| 35 | A framework for advancing our understanding of cancer-associated fibroblasts | Nature Reviews Cancer | 2020 | 2,012 |
| 36 | Identification of a receptor for the morphogen retinoic acid | Nature | 1987 | 1,983 |
| 37 | Phosphorylated CREB binds specifically to the nuclear protein CBP | Nature | 1993 | 1,978 |
| 38 | p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21 | Cell | 1994 | 1,976 |
| 39 | The possible role of hydrogen sulfide as an endogenous neuromodulator | Journal of Neuroscience | 1996 | 1,927 |
| 40 | A transcriptional co-repressor that interacts with nuclear hormone receptors | Nature | 1995 | 1,845 |
| 41 | Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo | Nature Biotechnology | 1997 | 1,826 |
| 42 | Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors | Cell | 1991 | 1,738 |
| 43 | Reliability of spike timing in neocortical neurons | Science | 1995 | 1,728 |
| 44 | The NIH Roadmap Epigenomics Mapping Consortium | Nature Biotechnology | 2010 | 1,705 |
| 45 | Protein Tyrosine Phosphatases in the Human Genome | Cell | 2004 | 1,697 |
| 46 | Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors | Nature | 1992 | 1,678 |
| 47 | Analysis of fMRI data by blind separation into independent spatial components | Human Brain Mapping | 1998 | 1,653 |
| 48 | A Theory of Self-Nonself Discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively | Science | 1970 | 1,603 |
| 49 | Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. | Genes and Development | 1995 | 1,600 |
| 50 | Reactive astrocytes: cellular and molecular cues to biological function | Trends in Neurosciences | 1997 | 1,591 |
