| # | Title | Journal | Year | Citations |
|---|
| 1 | Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria | Annals of Neurology | 2011 | 8,001 |
| 2 | Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA | Science | 1989 | 7,062 |
| 3 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell | Nature Medicine | 1997 | 6,150 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 5 | Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis | Lancet, The | 1992 | 4,291 |
| 6 | A cell initiating human acute myeloid leukaemia after transplantation into SCID mice | Nature | 1994 | 4,203 |
| 7 | Identification of the cystic fibrosis gene: genetic analysis | Science | 1989 | 3,921 |
| 8 | Identification of the cystic fibrosis gene: chromosome walking and jumping | Science | 1989 | 3,136 |
| 9 | Global landscape of protein complexes in the yeast Saccharomyces cerevisiae | Nature | 2006 | 2,681 |
| 10 | The Treatment-Naive Microbiome in New-Onset Crohn’s Disease | Cell Host and Microbe | 2014 | 2,582 |
| 11 | Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost? | Lancet, The | 2013 | 2,031 |
| 12 | The Wilson disease gene is a putative copper transporting P–type ATPase similar to the Menkes gene | Nature Genetics | 1993 | 1,855 |
| 13 | The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1 | Epilepsia | 2011 | 1,454 |
| 14 | Injuries Involving the Epiphyseal Plate | Journal of Bone and Joint Surgery - Series A | 1963 | 1,446 |
| 15 | Regulation of NMDA receptor trafficking by amyloid-β | Nature Neuroscience | 2005 | 1,417 |
| 16 | Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1 | Nature Genetics | 1994 | 1,416 |
| 17 | Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. | Circulation | 1993 | 1,408 |
| 18 | Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles | Molecular Cell | 2015 | 1,408 |
| 19 | Infection by verocytotoxin-producing Escherichia coli | Clinical Microbiology Reviews | 1989 | 1,379 |
| 20 | Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray | Epigenetics | 2013 | 1,276 |
| 21 | Pediatric modification of the Montreal classification for inflammatory bowel disease | Inflammatory Bowel Diseases | 2011 | 1,182 |
| 22 | Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women | Journal of the American College of Cardiology | 1994 | 1,175 |
| 23 | Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction | Journal of the American College of Cardiology | 1994 | 1,161 |
| 24 | Medulloblastoma Comprises Four Distinct Molecular Variants | Journal of Clinical Oncology | 2011 | 1,131 |
| 25 | Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry | Nature Immunology | 2010 | 1,125 |
| 26 | Sexual dimorphism of brain developmental trajectories during childhood and adolescence | NeuroImage | 2007 | 1,121 |
| 27 | Effect of neonatal circumcision on pain response during subsequent routine vaccination | Lancet, The | 1997 | 1,116 |
| 28 | Interaction network containing conserved and essential protein complexes in Escherichia coli | Nature | 2005 | 1,093 |
| 29 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 30 | STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD | Gastroenterology | 2021 | 1,054 |
| 31 | Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission | Nature Communications | 2020 | 1,042 |
| 32 | Different immune cells mediate mechanical pain hypersensitivity in male and female mice | Nature Neuroscience | 2015 | 1,041 |
| 33 | Cerebral Sinovenous Thrombosis in Children | New England Journal of Medicine | 2001 | 1,016 |
| 34 | HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the Channelopathies and Cardiomyopathies | Heart Rhythm | 2011 | 995 |
| 35 | The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis.. | British Journal of Dermatology | 1994 | 990 |
| 36 | Iron-Chelating Therapy and the Treatment of Thalassemia | Blood | 1997 | 971 |
| 37 | Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines | Science | 1983 | 959 |
| 38 | Prediction of Mortality in Patients with Cystic Fibrosis | New England Journal of Medicine | 1992 | 928 |
| 39 | WFH Guidelines for the Management of Hemophilia, 3rd edition | Haemophilia | 2020 | 915 |
| 40 | 2013 IDSA Clinical Practice Guideline for Vaccination of the Immunocompromised Host | Clinical Infectious Diseases | 2014 | 910 |
| 41 | Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection | JAMA Pediatrics | 2021 | 910 |
| 42 | Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies | BMJ, The | 2015 | 904 |
| 43 | Stem cell gene expression programs influence clinical outcome in human leukemia | Nature Medicine | 2011 | 894 |
| 44 | Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome | Nature Genetics | 1995 | 892 |
| 45 | Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor | Nature | 1996 | 879 |
| 46 | How I treat hemophagocytic lymphohistiocytosis | Blood | 2011 | 872 |
| 47 | Joint European League Against Rheumatism and European Renal Association–European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis | Annals of the Rheumatic Diseases | 2012 | 868 |
| 48 | Survival in Medically Treated Patients with Homozygous β-Thalassemia | New England Journal of Medicine | 1994 | 829 |
| 49 | Executive Summary: 2013 IDSA Clinical Practice Guideline for Vaccination of the Immunocompromised Host | Clinical Infectious Diseases | 2014 | 825 |
| 50 | Birth defects after maternal exposure to corticosteroids: Prospective cohort study and meta-analysis of epidemiological studies | Teratology | 2000 | 823 |
