| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C | Nature Genetics | 2009 | 2,124 |
| 3 | CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1 | Nature Genetics | 1994 | 1,717 |
| 4 | Reconstitution of I(KATP): An Inward Rectifier Subunit Plus the Sulfonylurea Receptor | Science | 1995 | 1,658 |
| 5 | Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice | Journal of Cell Biology | 2003 | 1,557 |
| 6 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 7 | Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy | New England Journal of Medicine | 2017 | 1,228 |
| 8 | Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues | Oncogene | 2006 | 1,088 |
| 9 | TFOS DEWS II pathophysiology report | Ocular Surface | 2017 | 1,049 |
| 10 | Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer | Cell | 2002 | 957 |
| 11 | Gut microbiota in the pathogenesis of inflammatory bowel disease | Clinical Journal of Gastroenterology | 2018 | 904 |
| 12 | Internal tandem duplication of the flt3 gene found in acute myeloid leukemia | Leukemia | 1996 | 903 |
| 13 | Representation of Action-Specific Reward Values in the Striatum | Science | 2005 | 823 |
| 14 | Expression of cyclooxygenase-1 and -2 in human colorectal cancer | Cancer Research | 1995 | 810 |
| 15 | Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival | Nature Medicine | 2012 | 721 |
| 16 | Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus | Nature Genetics | 2008 | 694 |
| 17 | The Severity of Ultrasonographic Findings in Nonalcoholic Fatty Liver Disease Reflects the Metabolic Syndrome and Visceral Fat Accumulation | American Journal of Gastroenterology | 2007 | 688 |
| 18 | Endoscopic sphincterotomy of the ampulla of Vater | Gastrointestinal Endoscopy | 1974 | 672 |
| 19 | Functional aspects of the tear film lipid layer | Experimental Eye Research | 2004 | 647 |
| 20 | Corneal transplantation | Lancet, The | 2012 | 642 |
| 21 | The International Workshop on Meibomian Gland Dysfunction: Report of the Diagnosis Subcommittee | | 2011 | 634 |
| 22 | Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease Than Transient Elastography | Gastroenterology | 2016 | 628 |
| 23 | Is Neisseria gonorrhoeae Initiating a Future Era of Untreatable Gonorrhea?: Detailed Characterization of the First Strain with High-Level Resistance to Ceftriaxone | Antimicrobial Agents and Chemotherapy | 2011 | 600 |
| 24 | Association Between Fibrosis Stage and Outcomes of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis | Gastroenterology | 2020 | 575 |
| 25 | Circulating microRNAs in plasma of patients with gastric cancers | British Journal of Cancer | 2010 | 573 |
| 26 | Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial | Lancet, The | 2012 | 560 |
| 27 | Collinear stimuli regulate visual responses depending on cell's contrast threshold | Nature | 1998 | 559 |
| 28 | New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals | Nature Cell Biology | 2000 | 543 |
| 29 | Association of Non-alcoholic Fatty Liver Disease with Chronic Kidney Disease: A Systematic Review and Meta-analysis | PLoS Medicine | 2014 | 507 |
| 30 | Spatial and temporal expression pattern of N-cadherin cell adhesion molecules correlated with morphogenetic processes of chicken embryos | Developmental Biology | 1987 | 506 |
| 31 | Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus: Second Edition | Neurologia Medico-Chirurgica | 2012 | 506 |
| 32 | Impact of recombinant soluble thrombomodulin (thrombomodulin alfa) on disseminated intravascular coagulation | Thrombosis Research | 2013 | 506 |
| 33 | Stromal cell–derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model | Arthritis and Rheumatism | 2009 | 499 |
| 34 | Histone Deacetylase 3 (HDAC3) and Other Class I HDACs Regulate Colon Cell Maturation and p21 Expression and Are Deregulated in Human Colon Cancer | Journal of Biological Chemistry | 2006 | 486 |
| 35 | Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease | World Journal of Gastroenterology | 2007 | 469 |
| 36 | Characterization of 21 newly established esophageal cancer cell lines | Cancer | 1992 | 468 |
| 37 | Limitations of liver biopsy and non-invasive diagnostic tests for the diagnosis of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis | World Journal of Gastroenterology | 2014 | 453 |
| 38 | Growth factors: importance in wound healing and maintenance of transparency of the cornea | Progress in Retinal and Eye Research | 2000 | 452 |
| 39 | Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease | Neurology | 2010 | 449 |
| 40 | Cultivated corneal epithelial stem cell transplantation in ocular surface disorders11The authors have no financial interest in this work. | Ophthalmology | 2001 | 444 |
| 41 | Nox1 Is Involved in Angiotensin II–Mediated Hypertension | Circulation | 2005 | 443 |
| 42 | Side effects of high-dose interferon therapy for chronic hepatitis C | Journal of Hepatology | 1996 | 441 |
| 43 | A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis | Nature Genetics | 2007 | 435 |
| 44 | Distribution of glucocorticoid receptor immunoreactivity and mRNA in the rat brain: an immunohistochemical and in situ hybridization study | Neuroscience Research | 1996 | 432 |
| 45 | Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines | Leukemia | 1997 | 422 |
| 46 | Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product | Leukemia | 1998 | 422 |
| 47 | Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial | Gut | 2020 | 411 |
| 48 | Narrow‐band imaging (NBI) magnifying endoscopic classification of colorectal tumors proposed by the Japan NBI Expert Team | Digestive Endoscopy | 2016 | 410 |
| 49 | Constitutive Expression of AID Leads to Tumorigenesis | Journal of Experimental Medicine | 2003 | 405 |
| 50 | The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza | Cell | 2013 | 399 |
