| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 2 | Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease | New England Journal of Medicine | 2010 | 2,710 |
| 3 | Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease | Nature Genetics | 2009 | 2,155 |
| 4 | Epidemiology and Natural History of Inflammatory Bowel Diseases | Gastroenterology | 2011 | 1,718 |
| 5 | Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease | Nature Genetics | 2011 | 1,708 |
| 6 | Large-scale association analysis identifies new risk loci for coronary artery disease | Nature Genetics | 2013 | 1,439 |
| 7 | Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target | American Journal of Gastroenterology | 2015 | 1,425 |
| 8 | Reversible anionic redox chemistry in high-capacity layered-oxide electrodes | Nature Materials | 2013 | 1,192 |
| 9 | Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein | Viruses | 2012 | 1,086 |
| 10 | Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial | Lancet, The | 2014 | 1,008 |
| 11 | Origin of voltage decay in high-capacity layered oxide electrodes | Nature Materials | 2015 | 757 |
| 12 | Subcutaneous Golimumab Induces Clinical Response and Remission in Patients With Moderate-to-Severe Ulcerative Colitis | Gastroenterology | 2014 | 753 |
| 13 | Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways | Nature Genetics | 2012 | 746 |
| 14 | Can Clinically Significant Prostate Cancer Be Detected with Multiparametric Magnetic Resonance Imaging? A Systematic Review of the Literature | European Urology | 2015 | 657 |
| 15 | European Stroke Organisation (ESO) Guidelines for the Management of Spontaneous Intracerebral Hemorrhage | International Journal of Stroke | 2014 | 638 |
| 16 | Dynamic Frequency Control Support by Energy Storage to Reduce the Impact of Wind and Solar Generation on Isolated Power System's Inertia | IEEE Transactions on Sustainable Energy | 2012 | 621 |
| 17 | Effects of Vedolizumab Induction Therapy for Patients With Crohn’s Disease in Whom Tumor Necrosis Factor Antagonist Treatment Failed | Gastroenterology | 2014 | 607 |
| 18 | Subcutaneous Golimumab Maintains Clinical Response in Patients With Moderate-to-Severe Ulcerative Colitis | Gastroenterology | 2014 | 605 |
| 19 | Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations | Nature Genetics | 2009 | 585 |
| 20 | Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture | Nature Genetics | 2013 | 578 |
| 21 | Image-Guided Prostate Biopsy Using Magnetic Resonance Imaging–Derived Targets: A Systematic Review | European Urology | 2013 | 479 |
| 22 | A new highly penetrant form of obesity due to deletions on chromosome 16p11.2 | Nature | 2010 | 476 |
| 23 | Selective catalytic oxidation of glycerol: perspectives for high value chemicals | Green Chemistry | 2011 | 468 |
| 24 | Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children | PLoS Medicine | 2011 | 446 |
| 25 | NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer | Journal of Clinical Investigation | 2013 | 444 |
| 26 | Increased Risk for Nonmelanoma Skin Cancers in Patients Who Receive Thiopurines for Inflammatory Bowel Disease | Gastroenterology | 2011 | 431 |
| 27 | Diagnosis of polycystic ovary syndrome (PCOS): revisiting the threshold values of follicle count on ultrasound and of the serum AMH level for the definition of polycystic ovaries | Human Reproduction | 2011 | 399 |
| 28 | A new prognostic clinicopathological classification of pituitary adenomas: a multicentric case–control study of 410 patients with 8 years post-operative follow-up | Acta Neuropathologica | 2013 | 395 |
| 29 | Standards of Reporting for MRI-targeted Biopsy Studies (START) of the Prostate: Recommendations from an International Working Group | European Urology | 2013 | 383 |
| 30 | Kupffer cells promote hepatic steatosis via interleukin-1β-dependent suppression of peroxisome proliferator-activated receptor α activity | Hepatology | 2010 | 381 |
| 31 | Glycerol dehydration to acrolein in the context of new uses of glycerol | Green Chemistry | 2010 | 374 |
| 32 | A 16-yr Follow-up of the European Randomized study of Screening for Prostate Cancer | European Urology | 2019 | 359 |
| 33 | Breast cancer risk–associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression | Nature Genetics | 2012 | 357 |
| 34 | Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes | Nature Genetics | 2018 | 356 |
| 35 | Electrochemical and XPS studies of the corrosion inhibition of carbon steel in hydrochloric acid pickling solutions by 3,5-bis(2-thienylmethyl)-4-amino-1,2,4-triazole | Corrosion Science | 2013 | 353 |
| 36 | Prostate Cancer Diagnosis: Multiparametric MR-targeted Biopsy with Cognitive and Transrectal US–MR Fusion Guidance versus Systematic Biopsy—Prospective Multicenter Study | Radiology | 2013 | 348 |
| 37 | Role of magnetic resonance imaging before initial biopsy: comparison of magnetic resonance imaging-targeted and systematic biopsy for significant prostate cancer detection | BJU International | 2011 | 341 |
| 38 | Long-term use of standardised ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial | Lancet Neurology, The | 2012 | 331 |
| 39 | Interactions between androgens, FSH, anti-Müllerian hormone and estradiol during folliculogenesis in the human normal and polycystic ovary | Human Reproduction Update | 2016 | 329 |
| 40 | Coordinative Chain Transfer Polymerization | Chemical Reviews | 2013 | 326 |
| 41 | Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology | Molecular Psychiatry | 2013 | 321 |
| 42 | Multivariate curve resolution: A review of advanced and tailored applications and challenges | Analytica Chimica Acta | 2013 | 321 |
| 43 | Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 315 |
| 44 | The Microbiota Mediates Pathogen Clearance from the Gut Lumen after Non-Typhoidal Salmonella Diarrhea | PLoS Pathogens | 2010 | 314 |
| 45 | Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia | Blood | 2013 | 313 |
| 46 | Secondary ketocarotenoid astaxanthin biosynthesis in algae: a multifunctional response to stress | Photosynthesis Research | 2010 | 310 |
| 47 | Bile Acids and Metabolic Regulation | Diabetes Care | 2009 | 304 |
| 48 | Frontotemporal dementia and its subtypes: a genome-wide association study | Lancet Neurology, The | 2014 | 302 |
| 49 | Magnetic Resonance Imaging in Active Surveillance of Prostate Cancer: A Systematic Review | European Urology | 2015 | 284 |
| 50 | Natural history of elderly-onset inflammatory bowel disease: a population-based cohort study | Gut | 2014 | 282 |
