| # | Title | Journal | Year | Citations |
|---|
| 1 | Particle mesh Ewald: AnN⋅log(N) method for Ewald sums in large systems | Journal of Chemical Physics | 1993 | 24,656 |
| 2 | A smooth particle mesh Ewald method | Journal of Chemical Physics | 1995 | 18,266 |
| 3 | Apoptosis: A Review of Programmed Cell Death | Toxicologic Pathology | 2007 | 10,063 |
| 4 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 9,397 |
| 5 | The Amber biomolecular simulation programs | Journal of Computational Chemistry | 2005 | 7,742 |
| 6 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,376 |
| 7 | A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1 | Science | 1994 | 5,747 |
| 8 | Integrative analysis of 111 reference human epigenomes | Nature | 2015 | 5,653 |
| 9 | Mutational heterogeneity in cancer and the search for new cancer-associated genes | Nature | 2013 | 4,761 |
| 10 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 11 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 12 | Microglia-mediated neurotoxicity: uncovering the molecular mechanisms | Nature Reviews Neuroscience | 2007 | 3,477 |
| 13 | Identification of the breast cancer susceptibility gene BRCA2 | Nature | 1995 | 3,230 |
| 14 | New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites | Gene | 1988 | 2,923 |
| 15 | An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress | Molecular Cell | 2003 | 2,791 |
| 16 | The Lancet Commission on pollution and health | Lancet, The | 2018 | 2,747 |
| 17 | Identification of the haematopoietic stem cell niche and control of the niche size | Nature | 2003 | 2,633 |
| 18 | Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses | Endocrine Reviews | 2012 | 2,413 |
| 19 | Chronic inflammation in the etiology of disease across the life span | Nature Medicine | 2019 | 2,195 |
| 20 | Incidence of Early Loss of Pregnancy | New England Journal of Medicine | 1988 | 2,130 |
| 21 | High cumulative incidence of uterine leiomyoma in black and white women: Ultrasound evidence | American Journal of Obstetrics and Gynecology | 2003 | 1,817 |
| 22 | Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration | Glia | 2007 | 1,778 |
| 23 | Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us? | Endocrine Reviews | 1999 | 1,759 |
| 24 | Genome-wide association study reveals genetic risk underlying Parkinson's disease | Nature Genetics | 2009 | 1,745 |
| 25 | Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer | Cell | 2017 | 1,742 |
| 26 | Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease | Nature Genetics | 2014 | 1,685 |
| 27 | Rates of Spontaneous Mutation | Genetics | 1998 | 1,672 |
| 28 | A Test of Neutral Molecular Evolution Based on Nucleotide Data | Genetics | 1987 | 1,666 |
| 29 | The Ames Salmonella/microsome mutagenicity assay | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis | 2000 | 1,600 |
| 30 | STATISTICAL PROPERTIES OF THE NUMBER OF RECOMBINATION EVENTS IN THE HISTORY OF A SAMPLE OF DNA SEQUENCES | Genetics | 1985 | 1,536 |
| 31 | EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals | Endocrine Reviews | 2015 | 1,508 |
| 32 | Capacitative calcium entry revisited | Cell Calcium | 1990 | 1,473 |
| 33 | T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ | Immunity | 2008 | 1,471 |
| 34 | Normalization and microbial differential abundance strategies depend upon data characteristics | Microbiome | 2017 | 1,434 |
| 35 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 36 | Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism | Progress in Neurobiology | 2005 | 1,350 |
| 37 | Essential autocrine regulation by IL-21 in the generation of inflammatory T cells | Nature | 2007 | 1,341 |
| 38 | Control of microglial neurotoxicity by the fractalkine receptor | Nature Neuroscience | 2006 | 1,334 |
| 39 | Microglial M1/M2 polarization and metabolic states | British Journal of Pharmacology | 2016 | 1,308 |
| 40 | Multiple Female Reproductive Failures in Cyclooxygenase 2–Deficient Mice | Cell | 1997 | 1,307 |
| 41 | Analysis of composition of microbiomes: a novel method for studying microbial composition | Microbial Ecology in Health and Disease | 2015 | 1,283 |
| 42 | Opportunities and obstacles for deep learning in biology and medicine | Journal of the Royal Society Interface | 2018 | 1,282 |
| 43 | ART: a next-generation sequencing read simulator | Bioinformatics | 2012 | 1,234 |
| 44 | Global, regional, and national levels and causes of maternal mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 1,230 |
| 45 | Molecular definitions of autophagy and related processes | EMBO Journal | 2017 | 1,230 |
| 46 | Capturing and profiling adult hair follicle stem cells | Nature Biotechnology | 2004 | 1,198 |
| 47 | DNA MISMATCH REPAIR | Annual Review of Biochemistry | 2005 | 1,174 |
| 48 | BRCA1 mutations in primary breast and ovarian carcinomas | Science | 1994 | 1,167 |
| 49 | The "hitchhiking effect" revisited. | Genetics | 1989 | 1,135 |
| 50 | A constant rate of spontaneous mutation in DNA-based microbes. | Proceedings of the National Academy of Sciences of the United States of America | 1991 | 1,101 |
