| # | Title | Journal | Year | Citations |
|---|
| 1 | Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial | Lancet Oncology, The | 2014 | 1,932 |
| 2 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial | Lancet, The | 2014 | 1,833 |
| 3 | LMNA, encoding lamin A/C, is mutated in partial lipodystrophy | Nature Genetics | 2000 | 653 |
| 4 | Percutaneous coronary angioplasty versus coronary artery bypass grafting in treatment of unprotected left main stenosis (NOBLE): a prospective, randomised, open-label, non-inferiority trial | Lancet, The | 2016 | 620 |
| 5 | Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): a randomised controlled trial | Lancet, The | 2007 | 520 |
| 6 | Everolimus for Previously Treated Advanced Gastric Cancer: Results of the Randomized, Double-Blind, Phase III GRANITE-1 Study | Journal of Clinical Oncology | 2013 | 411 |
| 7 | ERCP-related adverse events: European Society of Gastrointestinal Endoscopy (ESGE) Guideline | Endoscopy | 2020 | 397 |
| 8 | Prevalence and determinants of undetected dementia in the community: a systematic literature review and a meta-analysis | BMJ Open | 2017 | 349 |
| 9 | Inflammatory bowel disease and domestic hygiene in infancy | Lancet, The | 1994 | 343 |
| 10 | Diabetic ketoacidosis in pregnancy | Postgraduate Medical Journal | 2003 | 313 |
| 11 | Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years | British Journal of Surgery | 2017 | 304 |
| 12 | Randomised controlled trial of nasal nicotine spray in smoking cessation | Lancet, The | 1992 | 290 |
| 13 | A rapid gas-liquid chromatographic method for the determination of cotinine and nicotine in biological fluids | Journal of Pharmacy and Pharmacology | 2011 | 285 |
| 14 | Passive smoking and risk of coronary heart disease and stroke: prospective study with cotinine measurement | BMJ: British Medical Journal | 2004 | 265 |
| 15 | The national colonoscopy audit: a nationwide assessment of the quality and safety of colonoscopy in the UK | Gut | 2013 | 248 |
| 16 | Quality standards in upper gastrointestinal endoscopy: a position statement of the British Society of Gastroenterology (BSG) and Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS) | Gut | 2017 | 243 |
| 17 | How commonly is upper gastrointestinal cancer missed at endoscopy? A meta-analysis | Endoscopy International Open | 2014 | 237 |
| 18 | Endoscopy in patients on antiplatelet or anticoagulant therapy, including direct oral anticoagulants: British Society of Gastroenterology (BSG) and European Society of Gastrointestinal Endoscopy (ESGE) guidelines | Gut | 2016 | 225 |
| 19 | Vitamin D: a negative acute phase reactant | Journal of Clinical Pathology | 2013 | 221 |
| 20 | Endoscopy and antiplatelet agents. European Society of Gastrointestinal Endoscopy (ESGE) Guideline | Endoscopy | 2011 | 216 |
| 21 | Defining response to anti-VEGF therapies in neovascular AMD | Eye | 2015 | 214 |
| 22 | Muscle soreness, swelling, stiffness and strength loss after intense eccentric exercise. | British Journal of Sports Medicine | 1992 | 213 |
| 23 | Impact of the COVID-19 pandemic on UK endoscopic activity and cancer detection: a National Endoscopy Database Analysis | Gut | 2021 | 209 |
| 24 | Guidelines for the management of anticoagulant and antiplatelet therapy in patients undergoing endoscopic procedures | Gut | 2008 | 199 |
| 25 | Error in Radiology | Clinical Radiology | 2001 | 198 |
| 26 | Parkinson's disease is overdiagnosed clinically at baseline in diagnostically uncertain cases: A 3‐year European multicenter study with repeat [123I]FP‐CIT SPECT | Movement Disorders | 2009 | 195 |
| 27 | Diagnosis and management of acute lower gastrointestinal bleeding: guidelines from the British Society of Gastroenterology | Gut | 2019 | 195 |
| 28 | 4 Gy versus 24 Gy radiotherapy for patients with indolent lymphoma (FORT): a randomised phase 3 non-inferiority trial | Lancet Oncology, The | 2014 | 191 |
| 29 | Once-per-week selinexor, bortezomib, and dexamethasone versus twice-per-week bortezomib and dexamethasone in patients with multiple myeloma (BOSTON): a randomised, open-label, phase 3 trial | Lancet, The | 2020 | 188 |
| 30 | British Society of Gastroenterology/Association of Coloproctologists of Great Britain and Ireland guidelines for the management of large non-pedunculated colorectal polyps | Gut | 2015 | 175 |
| 31 | Guidance on the management of diarrhoea during cancer chemotherapy | Lancet Oncology, The | 2014 | 171 |
| 32 | Endoscopy in patients on antiplatelet or anticoagulant therapy, including direct oral anticoagulants: British Society of Gastroenterology (BSG) and European Society of Gastrointestinal Endoscopy (ESGE) guidelines | Endoscopy | 2016 | 170 |
| 33 | Adenoma surveillance and colorectal cancer incidence: a retrospective, multicentre, cohort study | Lancet Oncology, The | 2017 | 169 |
| 34 | Good practice recommendations for outpatient parenteral antimicrobial therapy (OPAT) in adults in the UK: a consensus statement | Journal of Antimicrobial Chemotherapy | 2012 | 165 |
| 35 | The Heart Failure Revascularisation Trial (HEART) | European Journal of Heart Failure | 2011 | 164 |
| 36 | Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus | Nature Genetics | 2012 | 162 |
| 37 | Final results of the Royal College of Radiologists' trial comparing two different radiotherapy schedules in the treatment of cerebral metastases | Clinical Oncology | 1996 | 154 |
| 38 | The Treatment of Anal Fistula: ACPGBI Position Statement | Colorectal Disease | 2007 | 149 |
| 39 | Further observations on LKB1/STK11 status and cancer risk in Peutz–Jeghers syndrome | British Journal of Cancer | 2003 | 148 |
| 40 | Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers | European Urology | 2019 | 148 |
| 41 | Delayed onset muscle soreness: Mechanisms and management | Journal of Sports Sciences | 1992 | 147 |
| 42 | Histopathological evaluation of thrombus in patients presenting with stent thrombosis. A multicenter European study: a report of the prevention of late stent thrombosis by an interdisciplinary global European effort consortium | European Heart Journal | 2016 | 147 |
| 43 | A randomized, open-label study of the efficacy and safety of AZD4547 monotherapy versus paclitaxel for the treatment of advanced gastric adenocarcinoma with FGFR2 polysomy or gene amplification | Annals of Oncology | 2017 | 147 |
| 44 | A NEW STATISTICAL APPROACH TO THE PROGNOSTIC SIGNIFICANCE OF PLASMA PARAQUAT CONCENTRATIONS | Lancet, The | 1984 | 144 |
| 45 | Short-term safety outcomes of mastectomy and immediate implant-based breast reconstruction with and without mesh (iBRA): a multicentre, prospective cohort study | Lancet Oncology, The | 2019 | 141 |
| 46 | Factors affecting responses on Dermatology Life Quality Index items among vitiligo sufferers | Clinical and Experimental Dermatology | 1996 | 138 |
| 47 | 2016 European guideline on the management of non-gonococcal urethritis | International Journal of STD and AIDS | 2016 | 137 |
| 48 | Pulmonary Metastasectomy in Colorectal Cancer: updated analysis of 93 randomized patients – control survival is much better than previously assumed | Colorectal Disease | 2020 | 135 |
| 49 | PATTERNS OF EXPRESSION OF KERATIN 19 AS DETECTED WITH MONOCLONAL ANTIBODIES IN HUMAN BREAST TISSUES AND TUMOURS | International Journal of Cancer | 1985 | 126 |
| 50 | Prospective study of presynaptic dopaminergic imaging in patients with mild parkinsonism and tremor disorders: Part 1. Baseline and 3-month observations | Movement Disorders | 2003 | 124 |
