| # | Title | Journal | Year | Citations |
|---|
| 1 | Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations | Lancet, The | 2000 | 1,272 |
| 2 | Low mortality associated with low volume pressure limited ventilation with permissive hypercapnia in severe adult respiratory distress syndrome | Intensive Care Medicine | 1990 | 868 |
| 3 | Oral Ixazomib, Lenalidomide, and Dexamethasone for Multiple Myeloma | New England Journal of Medicine | 2016 | 861 |
| 4 | Low mortality rate in adult respiratory distress syndrome using low-volume, pressure-limited ventilation with permissive hypercapnia: A prospective study | Critical Care Medicine | 1994 | 682 |
| 5 | Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis | BMJ: British Medical Journal | 1996 | 680 |
| 6 | 2016 IMS Recommendations on women’s midlife health and menopause hormone therapy | Climacteric | 2016 | 676 |
| 7 | Structure and variation of human α1–antitrypsin | Nature | 1982 | 665 |
| 8 | Plasma N-Terminal Pro–Brain Natriuretic Peptide and Adrenomedullin | Circulation | 1998 | 625 |
| 9 | Minimum requirements for the diagnosis of psychogenic nonepileptic seizures: A staged approach | Epilepsia | 2013 | 601 |
| 10 | Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit | JAMA - Journal of the American Medical Association | 2015 | 582 |
| 11 | Parastomal hernia | British Journal of Surgery | 2003 | 557 |
| 12 | Modeling the Reactions of Superoxide and Myeloperoxidase in the Neutrophil Phagosome | Journal of Biological Chemistry | 2006 | 544 |
| 13 | Appendiceal tumors | Diseases of the Colon and Rectum | 1998 | 508 |
| 14 | Effects of Fenofibrate Treatment on Cardiovascular Disease Risk in 9,795 Individuals With Type 2 Diabetes and Various Components of the Metabolic Syndrome | Diabetes Care | 2009 | 488 |
| 15 | Safety and Efficacy of a Totally Subcutaneous Implantable-Cardioverter Defibrillator | Circulation | 2013 | 486 |
| 16 | Plasma brain natriuretic peptide in assessment of acute dyspnoea | Lancet, The | 1994 | 472 |
| 17 | A Simple Method for the Detection of Unstable Haemoglobins | British Journal of Haematology | 1972 | 471 |
| 18 | A double‐blind, placebo‐controlled study to assess the mitochondria‐targeted antioxidant MitoQ as a disease‐modifying therapy in Parkinson's disease | Movement Disorders | 2010 | 467 |
| 19 | Optic neuritis | Lancet Neurology, The | 2014 | 463 |
| 20 | Immunoreactive amino‐terminal pro‐brain natriuretic peptide (NT‐PROBNP): a new marker of cardiac impairment | Clinical Endocrinology | 1997 | 457 |
| 21 | Comparison of an everolimus-eluting bioresorbable scaffold with an everolimus-eluting metallic stent for the treatment of coronary artery stenosis (ABSORB II): a 3 year, randomised, controlled, single-blind, multicentre clinical trial | Lancet, The | 2016 | 451 |
| 22 | Using the lower limit of normal for the FEV1/FVC ratio reduces the misclassification of airway obstruction | Thorax | 2008 | 446 |
| 23 | Comparative reactivities of various biological compounds with myeloperoxidase-hydrogen peroxide-chloride, and similarity of oxidant to hypochlorite | Biochimica Et Biophysica Acta - General Subjects | 1985 | 434 |
| 24 | A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation* | Critical Care Medicine | 2013 | 423 |
| 25 | De novo mutations of SETBP1 cause Schinzel-Giedion syndrome | Nature Genetics | 2010 | 417 |
| 26 | Evaluation of the Second Generation of a Bioresorbable Everolimus-Eluting Vascular Scaffold for the Treatment of De Novo Coronary Artery Stenosis | Journal of the American College of Cardiology | 2011 | 410 |
| 27 | TUBERCULIN-INDUCED MITOSIS IN PERIPHERAL BLOOD LEUCOCYTES | Lancet, The | 1963 | 409 |
| 28 | B-Type Natriuretic Peptides and Ejection Fraction for Prognosis After Myocardial Infarction | Circulation | 2003 | 402 |
| 29 | α1-Antitrypsin and the serpins: variation and countervariation | Trends in Biochemical Sciences | 1985 | 400 |
| 30 | Prevalence and Comorbidity of DSM-III-R Diagnoses in a Birth Cohort of 15 Year Olds | Journal of the American Academy of Child and Adolescent Psychiatry | 1993 | 400 |
| 31 | Epidemiology and Natural History of Urinary Incontinence | International Urogynecology Journal | 2000 | 390 |
| 32 | Stereotactic ablative radiotherapy versus standard radiotherapy in stage 1 non-small-cell lung cancer (TROG 09.02 CHISEL): a phase 3, open-label, randomised controlled trial | Lancet Oncology, The | 2019 | 386 |
| 33 | Capecitabine, Bevacizumab, and Mitomycin in First-Line Treatment of Metastatic Colorectal Cancer: Results of the Australasian Gastrointestinal Trials Group Randomized Phase III MAX Study | Journal of Clinical Oncology | 2010 | 370 |
| 34 | 2-Hour Accelerated Diagnostic Protocol to Assess Patients With Chest Pain Symptoms Using Contemporary Troponins as the Only Biomarker | Journal of the American College of Cardiology | 2012 | 361 |
| 35 | Short-term androgen deprivation and radiotherapy for locally advanced prostate cancer: results from the Trans-Tasman Radiation Oncology Group 96.01 randomised controlled trial | Lancet Oncology, The | 2005 | 351 |
| 36 | Measuring cortisol in human psychobiological studies | Physiology and Behavior | 2007 | 341 |
| 37 | The effect of maternal depression on maternal ratings of child behavior | Journal of Abnormal Child Psychology | 1993 | 327 |
| 38 | What is an acceptable risk of major adverse cardiac event in chest pain patients soon after discharge from the Emergency Department? | International Journal of Cardiology | 2013 | 324 |
| 39 | Plasma N-terminal pro-brain natriuretic peptide and adrenomedullin | Journal of the American College of Cardiology | 2001 | 323 |
| 40 | Prevalence of traumatic brain injury among children, adolescents and young adults: Prospective evidence from a birth cohort | Brain Injury | 2008 | 322 |
| 41 | Surface interpolation with radial basis functions for medical imaging | IEEE Transactions on Medical Imaging | 1997 | 316 |
| 42 | A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): a prospective observational validation study | Lancet, The | 2011 | 316 |
| 43 | Elective surgery after acute diverticulitis | British Journal of Surgery | 2005 | 314 |
| 44 | Bile duct injury in the era of laparoscopic cholecystectomy | British Journal of Surgery | 2006 | 306 |
| 45 | A suggested approach to once‐daily aminoglycoside dosing. | British Journal of Clinical Pharmacology | 1995 | 296 |
| 46 | Quality of life after total laparoscopic hysterectomy versus total abdominal hysterectomy for stage I endometrial cancer (LACE): a randomised trial | Lancet Oncology, The | 2010 | 296 |
| 47 | Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes | Critical Care | 2017 | 290 |
| 48 | Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium | JAMA - Journal of the American Medical Association | 2016 | 289 |
| 49 | SMOKING, LUNG FUNCTION, AND α1-ANTITRYPSIN DEFICIENCY | Lancet, The | 1985 | 288 |
| 50 | On the participation of higher oxidation states of iron and copper in fenton reactions | Free Radical Biology and Medicine | 1989 | 285 |
