| # | Title | Journal | Year | Citations |
|---|
| 1 | Jalview Version 2—a multiple sequence alignment editor and analysis workbench | Bioinformatics | 2009 | 8,091 |
| 2 | Surfing the p53 network | Nature | 2000 | 6,352 |
| 3 | Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study | Lancet, The | 2012 | 4,855 |
| 4 | p53, guardian of the genome | Nature | 1992 | 4,739 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 6 | Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B | Nature | 1995 | 4,694 |
| 7 | PRODRG: a tool for high-throughput crystallography of protein–ligand complexes | Acta Crystallographica Section D: Biological Crystallography | 2004 | 4,230 |
| 8 | A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity | Science | 2007 | 3,884 |
| 9 | Specificity and mechanism of action of some commonly used protein kinase inhibitors | Biochemical Journal | 2000 | 3,878 |
| 10 | Allergic Rhinitis and its Impact on Asthma (ARIA) 2008* | Allergy: European Journal of Allergy and Clinical Immunology | 2008 | 3,827 |
| 11 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 12 | AMPK: a nutrient and energy sensor that maintains energy homeostasis | Nature Reviews Molecular Cell Biology | 2012 | 3,463 |
| 13 | Network pharmacology: the next paradigm in drug discovery | Nature Chemical Biology | 2008 | 3,165 |
| 14 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 15 | The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I | Critical Reviews in Biochemistry and Molecular Biology | 1995 | 3,080 |
| 16 | The ground state of embryonic stem cell self-renewal | Nature | 2008 | 3,057 |
| 17 | Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis | Lancet Neurology, The | 2015 | 2,776 |
| 18 | Specificity and mechanism of action of some commonly used protein kinase inhibitors | Biochemical Journal | 2000 | 2,718 |
| 19 | Discovery and refinement of loci associated with lipid levels | Nature Genetics | 2013 | 2,641 |
| 20 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 21 | Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα | Current Biology | 1997 | 2,612 |
| 22 | Mechanism of activation of protein kinase B by insulin and IGF-1. | EMBO Journal | 1996 | 2,599 |
| 23 | Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis | Nature Genetics | 2006 | 2,584 |
| 24 | The Structure and Regulation of Protein Phosphatases | Annual Review of Biochemistry | 1989 | 2,557 |
| 25 | AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism | Cell Metabolism | 2005 | 2,541 |
| 26 | Revised International Prognostic Scoring System for Myelodysplastic Syndromes | Blood | 2012 | 2,458 |
| 27 | Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression | NeuroSignals | 2013 | 2,288 |
| 28 | The selectivity of protein kinase inhibitors: a further update | Biochemical Journal | 2007 | 2,287 |
| 29 | Corporate social and environmental reporting | Accounting, Auditing and Accountability Journal | 1995 | 2,234 |
| 30 | Integrating cell-signalling pathways with NF-κB and IKK function | Nature Reviews Molecular Cell Biology | 2007 | 2,121 |
| 31 | Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents. | Circulation | 1994 | 2,056 |
| 32 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | Nature Genetics | 2015 | 2,054 |
| 33 | Dental caries | Lancet, The | 2007 | 2,025 |
| 34 | Metformin and reduced risk of cancer in diabetic patients | BMJ: British Medical Journal | 2005 | 2,018 |
| 35 | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk | Nature Genetics | 2010 | 1,982 |
| 36 | AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy | Nature Reviews Molecular Cell Biology | 2007 | 1,954 |
| 37 | Protein kinases — the major drug targets of the twenty-first century? | Nature Reviews Drug Discovery | 2002 | 1,944 |
| 38 | SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1 | FEBS Letters | 1995 | 1,930 |
| 39 | Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals | Nature Genetics | 2018 | 1,835 |
| 40 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 41 | Foundation literacy acquisition in European orthographies | British Journal of Psychology | 2003 | 1,708 |
| 42 | A classification of chronic pain for ICD-11 | Pain | 2015 | 1,701 |
| 43 | Cyanobacterial blooms | Nature Reviews Microbiology | 2018 | 1,671 |
| 44 | A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins | Cell | 1994 | 1,652 |
| 45 | Siglecs and their roles in the immune system | Nature Reviews Immunology | 2007 | 1,642 |
| 46 | Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis | Nature Genetics | 2010 | 1,631 |
| 47 | The Nrf2 regulatory network provides an interface between redox and intermediary metabolism | Trends in Biochemical Sciences | 2014 | 1,591 |
| 48 | Human osteoblast-like cells phagocytose metal particles and express the macrophage marker CD68 in vitro | Journal of Bone and Joint Surgery: British Volume | 2000 | 1,590 |
| 49 | A complex secretory program orchestrated by the inflammasome controls paracrine senescence | Nature Cell Biology | 2013 | 1,566 |
| 50 | Clinical and biological implications of driver mutations in myelodysplastic syndromes | Blood | 2013 | 1,562 |
