| # | Title | Journal | Year | Citations |
|---|
| 1 | Obsessional-compulsive problems: A cognitive-behavioural analysis | Behaviour Research and Therapy | 1985 | 1,533 |
| 2 | Modified Look-Locker inversion recovery (MOLLI) for high-resolutionT1 mapping of the heart | Magnetic Resonance in Medicine | 2004 | 1,485 |
| 3 | Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy | New England Journal of Medicine | 2009 | 1,471 |
| 4 | Clostridium difficile infection: new developments in epidemiology and pathogenesis | Nature Reviews Microbiology | 2009 | 1,249 |
| 5 | Enteral Nutrient Supply for Preterm Infants: Commentary From the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition | Journal of Pediatric Gastroenterology and Nutrition | 2010 | 1,206 |
| 6 | International evidence-based recommendations on ultrasound-guided vascular access | Intensive Care Medicine | 2012 | 1,199 |
| 7 | Acute renal failure in the ICU: risk factors and outcome evaluated by the SOFA score | Intensive Care Medicine | 2000 | 1,183 |
| 8 | Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes | Nature Genetics | 2018 | 1,124 |
| 9 | Current concepts in the management of Helicobacter pylori infection—The Maastricht 2‐2000 Consensus Report | Alimentary Pharmacology and Therapeutics | 2002 | 1,068 |
| 10 | The Complement Inhibitor Eculizumab in Paroxysmal Nocturnal Hemoglobinuria | New England Journal of Medicine | 2006 | 1,060 |
| 11 | Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial | Lancet, The | 1999 | 1,041 |
| 12 | Role of circumferential margin involvement in the local recurrence of rectal cancer | Lancet, The | 1994 | 989 |
| 13 | Cardiovascular magnetic resonance and single-photon emission computed tomography for diagnosis of coronary heart disease (CE-MARC): a prospective trial | Lancet, The | 2012 | 936 |
| 14 | Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist | Arthritis and Rheumatism | 1998 | 920 |
| 15 | Ultrasound assessment of the polycystic ovary: international consensus definitions | Human Reproduction Update | 2003 | 857 |
| 16 | Clinicopathological definition of Waldenstrom's macroglobulinemia: Consensus Panel Recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia | Seminars in Oncology | 2003 | 841 |
| 17 | Long-Term Outcomes After Transcatheter Aortic Valve Implantation in High-Risk Patients With Severe Aortic Stenosis | Journal of the American College of Cardiology | 2011 | 839 |
| 18 | Complementary Feeding: A Commentary by the ESPGHAN Committee on Nutrition | Journal of Pediatric Gastroenterology and Nutrition | 2008 | 788 |
| 19 | Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data | BMJ: British Medical Journal | 2010 | 765 |
| 20 | Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus | Nature Genetics | 2006 | 752 |
| 21 | Increased Local Recurrence and Reduced Survival From Colorectal Cancer Following Anastomotic Leak | Annals of Surgery | 2011 | 725 |
| 22 | Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature | Nature Genetics | 2012 | 712 |
| 23 | Mortality and Cancer Incidence in Acromegaly: A Retrospective Cohort Study1 | Journal of Clinical Endocrinology and Metabolism | 1998 | 705 |
| 24 | Internal construct validity of the Warwick-Edinburgh Mental Well-being Scale (WEMWBS): a Rasch analysis using data from the Scottish Health Education Population Survey | Health and Quality of Life Outcomes | 2009 | 700 |
| 25 | Normal human left and right ventricular dimensions for MRI as assessed by turbo gradient echo and steady‐state free precession imaging sequences | Journal of Magnetic Resonance Imaging | 2003 | 660 |
| 26 | Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial | Lancet, The | 2007 | 660 |
| 27 | Prevalence of, and Risk Factors for, Chronic Idiopathic Constipation in the Community: Systematic Review and Meta-analysis | American Journal of Gastroenterology | 2011 | 645 |
| 28 | A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma | Arthritis and Rheumatism | 2006 | 632 |
| 29 | The value of sonography in the detection of bone erosions in patients with rheumatoid arthritis: A comparison with conventional radiography | Arthritis and Rheumatism | 2000 | 611 |
| 30 | Presence of significant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug–induced clinical remission: Evidence from an imaging study may explain structural progression | Arthritis and Rheumatism | 2006 | 606 |
| 31 | APACHE-II SCORE FOR ASSESSMENT AND MONITORING OF ACUTE PANCREATITIS | Lancet, The | 1989 | 604 |
| 32 | Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED) | Endoscopy | 2012 | 594 |
| 33 | Handover of responsibility for the anaesthetised patient - opinion and practice | Anaesthesia | 2004 | 572 |
| 34 | EBIC-Guidelines for management of severe head injury in adults | Acta Neurochirurgica | 1997 | 565 |
| 35 | Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells | Arthritis and Rheumatism | 2002 | 563 |
| 36 | The function of immunoglobulin A in immunity | Journal of Pathology | 2006 | 555 |
| 37 | Classification of inflammatory arthritis by enthesitis | Lancet, The | 1998 | 553 |
| 38 | Imaging techniques for assessment of inflammatory bowel disease: Joint ECCO and ESGAR evidence-based consensus guidelines | Journal of Crohn's and Colitis | 2013 | 541 |
| 39 | Alemtuzumab Compared With Chlorambucil As First-Line Therapy for Chronic Lymphocytic Leukemia | Journal of Clinical Oncology | 2007 | 533 |
| 40 | Obesity in anaesthesia and intensive care | British Journal of Anaesthesia | 2000 | 531 |
| 41 | Efficacy of Biological Therapies in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis | American Journal of Gastroenterology | 2011 | 523 |
| 42 | Very early treatment with infliximab in addition to methotrexate in early, poor‐prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: Results from a twelve‐month randomized, double‐blind, placebo‐controlled trial | Arthritis and Rheumatism | 2005 | 521 |
| 43 | Breast‐feeding: A Commentary by the ESPGHAN Committee on Nutrition | Journal of Pediatric Gastroenterology and Nutrition | 2009 | 510 |
| 44 | EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis | Annals of the Rheumatic Diseases | 2013 | 504 |
| 45 | Randomized Trial of Diaspirin Cross-linked Hemoglobin Solution as an Alternative to Blood Transfusion after Cardiac Surgery | Anesthesiology | 2000 | 498 |
| 46 | Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline | Endoscopy | 2013 | 498 |
| 47 | BTS guidelines for the management of spontaneous pneumothorax | Thorax | 2003 | 483 |
| 48 | Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria | Blood | 2007 | 481 |
| 49 | A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium | Nature Genetics | 2009 | 481 |
| 50 | Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: Twelve‐month results of a phase iib, double‐blind, randomized, placebo‐controlled trial | Arthritis and Rheumatism | 2005 | 456 |
