| # | Title | Journal | Year | Citations |
|---|
| 1 | Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock* | Critical Care Medicine | 2006 | 7,176 |
| 2 | Diversity of the Human Intestinal Microbial Flora | Science | 2005 | 6,617 |
| 3 | The gut microbiota as an environmental factor that regulates fat storage | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 5,131 |
| 4 | The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups | Nature | 2012 | 4,708 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 6 | Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria | Lancet Neurology, The | 2018 | 4,605 |
| 7 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 | Intensive Care Medicine | 2017 | 4,590 |
| 8 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015 | JAMA Oncology | 2017 | 4,254 |
| 9 | Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus | Arthritis and Rheumatism | 2012 | 3,838 |
| 10 | Allergic Rhinitis and its Impact on Asthma (ARIA) 2008* | Allergy: European Journal of Allergy and Clinical Immunology | 2008 | 3,827 |
| 11 | Improved method for high efficiency transformation of intact yeast cells | Nucleic Acids Research | 1992 | 3,171 |
| 12 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 13 | REDISCOVERY OF TRADITIONAL ECOLOGICAL KNOWLEDGE AS ADAPTIVE MANAGEMENT | Autophagy | 2000 | 2,464 |
| 14 | Clinical Practice Guideline for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer: 2010 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2011 | 2,434 |
| 15 | Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method | Methods in Enzymology | 2002 | 2,406 |
| 16 | Plant growth promoting rhizobacteria as biofertilizers | Plant and Soil | 2003 | 2,351 |
| 17 | TANDEM: matching proteins with tandem mass spectra | Bioinformatics | 2004 | 2,345 |
| 18 | A meta-analytic examination of the correlates of the three dimensions of job burnout. | Journal of Applied Psychology | 1996 | 2,334 |
| 19 | Randomised trial of interferon α2b plus ribavirin for 48 weeks or for 24 weeks versus interferon α2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus | Lancet, The | 1998 | 2,268 |
| 20 | International Clinical Practice Guidelines for the Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in Women: A 2010 Update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases | Clinical Infectious Diseases | 2011 | 2,194 |
| 21 | High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method | Nature Protocols | 2007 | 2,082 |
| 22 | Infliximab Maintenance Therapy for Fistulizing Crohn's Disease | New England Journal of Medicine | 2004 | 2,026 |
| 23 | Deep Learning‐Based Crack Damage Detection Using Convolutional Neural Networks | Computer-Aided Civil and Infrastructure Engineering | 2017 | 2,022 |
| 24 | Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial | Lancet, The | 2007 | 1,982 |
| 25 | Initiation of Inappropriate Antimicrobial Therapy Results in a Fivefold Reduction of Survival in Human Septic Shock | Chest | 2009 | 1,941 |
| 26 | Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure | Yeast | 1995 | 1,939 |
| 27 | Histone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions | Science | 2006 | 1,881 |
| 28 | 2002 Guidelines for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer | Clinical Infectious Diseases | 2002 | 1,738 |
| 29 | Banff 07 Classification of Renal Allograft Pathology: Updates and Future Directions | American Journal of Transplantation | 2008 | 1,710 |
| 30 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 | JAMA Oncology | 2019 | 1,691 |
| 31 | Presentation adapting a clinical comorbidity index for use with ICD-9-CM administrative data: Differing perspectives | Journal of Clinical Epidemiology | 1993 | 1,615 |
| 32 | Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report | Journal of Allergy and Clinical Immunology | 2010 | 1,614 |
| 33 | Diagnosis, Prevention, and Treatment of Catheter-Associated Urinary Tract Infection in Adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America | Clinical Infectious Diseases | 2010 | 1,604 |
| 34 | Biomass pretreatment: Fundamentals toward application | Biotechnology Advances | 2011 | 1,544 |
| 35 | Evolution of co-management: Role of knowledge generation, bridging organizations and social learning | Journal of Environmental Management | 2009 | 1,517 |
| 36 | Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 | Intensive Care Medicine | 2021 | 1,503 |
| 37 | Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome | Sleep Medicine | 2003 | 1,488 |
| 38 | Mortality and Apnea Index in Obstructive Sleep Apnea | Chest | 1988 | 1,471 |
| 39 | The Effect of Bisoprolol on Perioperative Mortality and Myocardial Infarction in High-Risk Patients Undergoing Vascular Surgery | New England Journal of Medicine | 1999 | 1,466 |
| 40 | The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level | JAMA Oncology | 2017 | 1,448 |
| 41 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 42 | Infectious Diseases Society of America Guidelines for the Diagnosis and Treatment of Asymptomatic Bacteriuria in Adults | Clinical Infectious Diseases | 2005 | 1,371 |
| 43 | 2012 Infectious Diseases Society of America Clinical Practice Guideline for the Diagnosis and Treatment of Diabetic Foot Infectionsa | Clinical Infectious Diseases | 2012 | 1,348 |
| 44 | The natural history of atrial fibrillation: Incidence, risk factors, and prognosis in the manitoba follow-up study | American Journal of Medicine | 1995 | 1,334 |
| 45 | Early infancy microbial and metabolic alterations affect risk of childhood asthma | Science Translational Medicine | 2015 | 1,277 |
| 46 | Nomenclature of Amphiboles; Report of the Subcommittee on Amphiboles of the International Mineralogical Association Commission on New Minerals and Mineral Names | Mineralogical Magazine | 1997 | 1,264 |
| 47 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016 | JAMA Oncology | 2018 | 1,260 |
| 48 | Osteoporosis | Lancet, The | 2019 | 1,252 |
| 49 | Diversity of structures and properties among catalases | Cellular and Molecular Life Sciences | 2004 | 1,243 |
| 50 | A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression | Nature | 1997 | 1,204 |
