| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | YET ANOTHER CHAOTIC ATTRACTOR | International Journal of Bifurcation and Chaos in Applied Sciences and Engineering | 1999 | 2,370 |
| 3 | Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome | Nature | 2013 | 1,774 |
| 4 | Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning | Nature Genetics | 1997 | 1,065 |
| 5 | A Slicer-Mediated Mechanism for Repeat-Associated siRNA 5' End Formation in Drosophila | Science | 2007 | 1,065 |
| 6 | Electrodiagnostic criteria for diagnosis of ALS | Clinical Neurophysiology | 2008 | 927 |
| 7 | Genome evolution in the allotetraploid frog Xenopus laevis | Nature | 2016 | 849 |
| 8 | p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload | Nature | 2007 | 809 |
| 9 | A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application | Nature Immunology | 2013 | 783 |
| 10 | Comparative Metagenomics Revealed Commonly Enriched Gene Sets in Human Gut Microbiomes | DNA Research | 2007 | 760 |
| 11 | An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy | Nature | 1998 | 758 |
| 12 | Therapy for thymic epithelial tumors: a clinical study of 1,320 patients from Japan | Annals of Thoracic Surgery | 2003 | 724 |
| 13 | Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways | Genes and Development | 2004 | 715 |
| 14 | ATP-sensitive K+ channel in the mitochondrial inner membrane | Nature | 1991 | 694 |
| 15 | Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus | Nature Genetics | 2008 | 694 |
| 16 | Search for Majorana Neutrinos Near the Inverted Mass Hierarchy Region with KamLAND-Zen | Physical Review Letters | 2016 | 672 |
| 17 | Femtosecond laser-assisted three-dimensional microfabrication in silica | Optics Letters | 2001 | 661 |
| 18 | Circulating Skeletal Stem Cells | Journal of Cell Biology | 2001 | 632 |
| 19 | Transcriptional Roles of Nuclear Factor κB and Nuclear Factor-Interleukin-6 in the Tumor Necrosis Factor α-Dependent Induction of Cyclooxygenase-2 in MC3T3-E1 Cells | Journal of Biological Chemistry | 1995 | 601 |
| 20 | Three-dimensional photonic crystal structures achieved with two-photon-absorption photopolymerization of resin | Applied Physics Letters | 1999 | 581 |
| 21 | Journey through the thymus: stromal guides for T-cell development and selection | Nature Reviews Immunology | 2006 | 579 |
| 22 | Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome | Genes and Development | 2006 | 566 |
| 23 | Mutation of DNASE1 in people with systemic lupus erythematosus | Nature Genetics | 2001 | 560 |
| 24 | Inhibition of protein phosphatases by microcystis and nodularin associated with hepatotoxicity | Journal of Cancer Research and Clinical Oncology | 1990 | 557 |
| 25 | Nanomedicine for drug delivery and imaging: A promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles | International Journal of Cancer | 2007 | 553 |
| 26 | A Vitamin D Receptor Gene Polymorphism in the Translation Initiation Codon: Effect on Protein Activity and Relation to Bone Mineral Density in Japanese Women | Journal of Bone and Mineral Research | 1997 | 552 |
| 27 | Effects of Extracranial–Intracranial Bypass for Patients With Hemorrhagic Moyamoya Disease | Stroke | 2014 | 533 |
| 28 | Application of moisturizer to neonates prevents development of atopic dermatitis | Journal of Allergy and Clinical Immunology | 2014 | 532 |
| 29 | Purification and subunit structure of hepatocyte growth factor from rat platelets | FEBS Letters | 1987 | 522 |
| 30 | A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins | Genes and Development | 2002 | 513 |
| 31 | lefty-1 Is Required for Left-Right Determination as a Regulator of lefty-2 and nodal | Cell | 1998 | 507 |
| 32 | Guidelines for the use of flow cytometry and cell sorting in immunological studies* | European Journal of Immunology | 2017 | 505 |
| 33 | Regulation of CD8+ T Cell Development by Thymus-Specific Proteasomes | Science | 2007 | 504 |
| 34 | Akt Enhances Mdm2-mediated Ubiquitination and Degradation of p53 | Journal of Biological Chemistry | 2002 | 503 |
| 35 | Estimating an EQ-5D population value set: the case of Japan | Health Economics (United Kingdom) | 2002 | 472 |
| 36 | Autophagy and autophagy-related proteins in the immune system | Nature Immunology | 2015 | 465 |
| 37 | Criteria for ductile fracture and their applications | Journal of Mechanical Working Technology | 1980 | 464 |
| 38 | The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans | Cell | 2002 | 456 |
| 39 | Inactivation of Stat5 in Mouse Mammary Epithelium during Pregnancy Reveals Distinct Functions in Cell Proliferation, Survival, and Differentiation | Molecular and Cellular Biology | 2004 | 449 |
| 40 | Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence | Nature Cell Biology | 2006 | 439 |
| 41 | The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance | Immunity | 2008 | 434 |
| 42 | Persistence and partitioning of eight selected pharmaceuticals in the aquatic environment: Laboratory photolysis, biodegradation, and sorption experiments | Water Research | 2009 | 434 |
| 43 | Adhesion testing of dentin bonding agents: A review | Dental Materials | 1995 | 419 |
| 44 | Autotaxin Stabilizes Blood Vessels and Is Required for Embryonic Vasculature by Producing Lysophosphatidic Acid | Journal of Biological Chemistry | 2006 | 418 |
| 45 | Direct Evidence that Dislocations are Non-Radiative Recombination Centers in GaN | Japanese Journal of Applied Physics | 1998 | 417 |
| 46 | Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells | Nature | 2008 | 417 |
| 47 | An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their dissemination | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 413 |
| 48 | Uncouplers of oxidative phosphorylation. | Environmental Health Perspectives | 1990 | 410 |
| 49 | Pimet, the Drosophila homolog of HEN1, mediates 2′-O-methylation of Piwi- interacting RNAs at their 3′ ends | Genes and Development | 2007 | 400 |
| 50 | Traditional medicine in Turkey X. Folk medicine in Central Anatolia | Journal of Ethnopharmacology | 2001 | 398 |
