| # | Title | Journal | Year | Citations |
|---|
| 1 | An analysis of the attrition of drug candidates from four major pharmaceutical companies | Nature Reviews Drug Discovery | 2015 | 996 |
| 2 | Race, Ethnicity, and NIH Research Awards | Science | 2011 | 797 |
| 3 | Increasing Prevalence of Atrial Fibrillation and Flutter in the United States | American Journal of Cardiology | 2009 | 746 |
| 4 | The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance | Nature Biotechnology | 2014 | 420 |
| 5 | The rise of research networks | Nature | 2012 | 331 |
| 6 | Determinants of corporate social responsibility disclosure: the case of Islamic banks | Journal of Islamic Accounting and Business Research | 2011 | 238 |
| 7 | Prevalence of clinical venous thromboembolism in the USA: Current trends and future projections | American Journal of Hematology | 2011 | 215 |
| 8 | Improving data transparency in clinical trials using blockchain smart contracts | F1000Research | 2016 | 215 |
| 9 | Real-time Rumor Debunking on Twitter | | 2015 | 205 |
| 10 | Reduction in Acute Gastroenteritis Hospitalizations among US Children After Introduction of Rotavirus Vaccine: Analysis of Hospital Discharge Data from 18 US States | Journal of Infectious Diseases | 2010 | 196 |
| 11 | Association between hypoglycaemic events and fall‐related fractures in Medicare‐covered patients with type 2 diabetes | Diabetes, Obesity and Metabolism | 2012 | 190 |
| 12 | The geological history of northwestern South America: from Pangaea to the early collision of the Caribbean Large Igneous Province (290–75Ma) | Gondwana Research | 2015 | 190 |
| 13 | Emergency Department Care in the United States: A Profile of National Data Sources | Annals of Emergency Medicine | 2010 | 173 |
| 14 | Evidence Linking Hypoglycemic Events to an Increased Risk of Acute Cardiovascular Events in Patients With Type 2 Diabetes | Diabetes Care | 2011 | 162 |
| 15 | Modifying the journal impact factor by fractional citation weighting: The audience factor | Journal of the Association for Information Science and Technology | 2008 | 157 |
| 16 | The use and misuse of journal metrics and other citation indicators | Archivum Immunologiae Et Therapiae Experimentalis | 2009 | 157 |
| 17 | An investigation of biomarkers derived from legacy microarray data for their utility in the RNA-seq era | Genome Biology | 2014 | 147 |
| 18 | Differential contributions of hippocampus and medial prefrontal cortex to self-projection and self-referential processing | Neuropsychologia | 2015 | 143 |
| 19 | Datapoints: Psychotropic Drug Prescriptions by Medical Specialty | Psychiatric Services | 2009 | 136 |
| 20 | The value of data | Nature Genetics | 2011 | 126 |
| 21 | Emerging research fronts in science and technology: patterns of new knowledge development | Scientometrics | 2010 | 123 |
| 22 | Duration of venous thromboembolism risk across a continuum in medically ill hospitalized patients | Journal of Hospital Medicine | 2012 | 118 |
| 23 | The Journal Impact Factor Denominator | JAMA - Journal of the American Medical Association | 2009 | 113 |
| 24 | The cost burden of oral, oral pharyngeal, and salivary gland cancers in three groups: commercial insurance, medicare, and medicaid | Head & Neck Oncology | 2012 | 106 |
| 25 | Long‐term medical costs and resource utilization in systemic lupus erythematosus and lupus nephritis: A five‐year analysis of a large medicaid population | Arthritis and Rheumatism | 2009 | 101 |
| 26 | Changes In US Spending On Mental Health And Substance Abuse Treatment, 1986–2005, And Implications For Policy | Health Affairs | 2011 | 100 |
| 27 | Recent Experience In Health Promotion At Johnson & Johnson: Lower Health Spending, Strong Return On Investment | Health Affairs | 2011 | 100 |
| 28 | The Association between Insomnia Severity and Healthcare and Productivity Costs in a Health Plan Sample | Sleep | 2011 | 98 |
| 29 | The economic burden of fibromyalgia: comparative analysis with rheumatoid arthritis | Current Medical Research and Opinion | 2009 | 96 |
| 30 | Epigenetic Regulation of Cell Type–Specific Expression Patterns in the Human Mammary Epithelium | PLoS Genetics | 2011 | 96 |
| 31 | Cost burden of treatment resistance in patients with depression | American Journal of Managed Care | 2010 | 90 |
| 32 | Antidepressant Use in Geriatric Populations: The Burden of Side Effects and Interactions and Their Impact on Adherence and Costs | American Journal of Geriatric Psychiatry | 2011 | 88 |
| 33 | Knowledge-based analysis of proteomics data | BMC Bioinformatics | 2012 | 88 |
| 34 | Association of insomnia severity and comorbid medical and psychiatric disorders in a health plan-based sample: Insomnia severity and comorbidities | Sleep Medicine | 2010 | 85 |
| 35 | Direct healthcare costs of hip, vertebral, and non-hip, non-vertebral fractures | Bone | 2009 | 83 |
| 36 | Treatment Patterns in the First Year After Initiating Tumor Necrosis Factor Blockers in Real-World Settings | Advances in Therapy | 2012 | 81 |
| 37 | Interpreting maps of science using citation context sentiments: a preliminary investigation | Scientometrics | 2011 | 80 |
| 38 | Event-Driven Trading and the “New News” | Journal of Portfolio Management | 2011 | 79 |
| 39 | Learning Bayesian network parameters under incomplete data with domain knowledge | Pattern Recognition | 2009 | 78 |
| 40 | Incidence and prevalence of idiopathic inflammatory myopathies among commercially insured, Medicare supplemental insured, and Medicaid enrolled populations: an administrative claims analysis | BMC Musculoskeletal Disorders | 2012 | 78 |
| 41 | Evolving BioAssay Ontology (BAO): modularization, integration and applications | Journal of Biomedical Semantics | 2014 | 75 |
| 42 | Systems-Based Analyses of Brain Regions Functionally Impacted in Parkinson's Disease Reveals Underlying Causal Mechanisms | PLoS ONE | 2014 | 74 |
| 43 | Effects of Oseltamivir on Influenza-Related Complications in Children With Chronic Medical Conditions | Pediatrics | 2009 | 73 |
| 44 | A Value-Based Insurance Design Program At A Large Company Boosted Medication Adherence For Employees With Chronic Illnesses | Health Affairs | 2011 | 64 |
| 45 | Seeking Cancer-Related Information From Media and Family/Friends Increases Fruit and Vegetable Consumption Among Cancer Patients | Health Communication | 2012 | 63 |
| 46 | Opportunities for and limitations of the Book Citation Index | Journal of the Association for Information Science and Technology | 2013 | 63 |
| 47 | Multimodal Entity Coreference for Cervical Dysplasia Diagnosis | IEEE Transactions on Medical Imaging | 2015 | 61 |
| 48 | A simple semi-supervised algorithm for named entity recognition | | 2009 | 61 |
| 49 | Cost Burden of Cardiovascular Hospitalization and Mortality in ATHENA‐Like Patients With Atrial Fibrillation/Atrial Flutter in the United States | Clinical Cardiology | 2010 | 57 |
| 50 | The Economic Value of Specialized Lower-Extremity Medical Care by Podiatric Physicians in the Treatment of Diabetic Foot Ulcers | Journal of the American Podiatric Medical Association | 2011 | 56 |
