| # | Title | Journal | Year | Citations |
|---|
| 1 | Methodological index for non-randomized studies (MINORS ): development and validation of a new instrument | ANZ Journal of Surgery | 2003 | 4,914 |
| 2 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration | Lancet Neurology, The | 2013 | 3,919 |
| 3 | Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 3,581 |
| 4 | Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4) | Pain | 2005 | 1,969 |
| 5 | Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials | Lancet Neurology, The | 2007 | 1,580 |
| 6 | Cerebral dural arteriovenous fistulas: clinical and angiographic correlation with a revised classification of venous drainage. | Radiology | 1995 | 1,485 |
| 7 | Molecular Mechanisms of Myocardial Remodeling | Physiological Reviews | 1999 | 1,451 |
| 8 | Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism | Journal of the American College of Cardiology | 2005 | 1,359 |
| 9 | Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study | Lancet, The | 2008 | 1,258 |
| 10 | The RESTORE Study | Ophthalmology | 2011 | 1,212 |
| 11 | Echocardiography in the intensive care unit: from evolution to revolution? | Intensive Care Medicine | 2008 | 1,195 |
| 12 | Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach | Lancet Infectious Diseases, The | 2013 | 1,138 |
| 13 | Vascular Anomalies Classification: Recommendations From the International Society for the Study of Vascular Anomalies | Pediatrics | 2015 | 1,026 |
| 14 | CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands | Nature Medicine | 2016 | 1,001 |
| 15 | Arterial embolisation to treat uterine myomata | Lancet, The | 1995 | 999 |
| 16 | Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial | Lancet, The | 2009 | 995 |
| 17 | A Review of Activity Indices and Efficacy End Points for Clinical Trials of Medical Therapy in Adults With Ulcerative Colitis | Gastroenterology | 2007 | 917 |
| 18 | The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. A prospective series of 67 patients | Brain | 2007 | 911 |
| 19 | Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE | American Journal of Physiology - Endocrinology and Metabolism | 2001 | 890 |
| 20 | The International Vitreomacular Traction Study Group Classification of Vitreomacular Adhesion, Traction, and Macular Hole | Ophthalmology | 2013 | 855 |
| 21 | Elevated Levels of Shed Membrane Microparticles With Procoagulant Potential in the Peripheral Circulating Blood of Patients With Acute Coronary Syndromes | Circulation | 2000 | 851 |
| 22 | A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome | Nature Genetics | 1997 | 844 |
| 23 | Catecholaminergic Polymorphic Ventricular Tachycardia in Children | Circulation | 1995 | 820 |
| 24 | Gout | Lancet, The | 2010 | 818 |
| 25 | Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy | European Journal of Heart Failure | 2010 | 787 |
| 26 | Improved Automated Detection of Diabetic Retinopathy on a Publicly Available Dataset Through Integration of Deep Learning | European Journal of Heart Failure | 2016 | 749 |
| 27 | Sequential-Design, Multicenter, Randomized, Controlled Trial of Early Decompressive Craniectomy in Malignant Middle Cerebral Artery Infarction (DECIMAL Trial) | Stroke | 2007 | 726 |
| 28 | Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma | Lancet, The | 2000 | 698 |
| 29 | State of the art: Using natriuretic peptide levels in clinical practice | European Journal of Heart Failure | 2008 | 691 |
| 30 | Reversible cerebral vasoconstriction syndrome | Lancet Neurology, The | 2012 | 674 |
| 31 | A contribution of image processing to the diagnosis of diabetic retinopathy-detection of exudates in color fundus images of the human retina | IEEE Transactions on Medical Imaging | 2002 | 667 |
| 32 | Safety and Efficacy of Ranibizumab in Diabetic Macular Edema (RESOLVE Study) | Diabetes Care | 2010 | 656 |
| 33 | Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients | Lancet, The | 1997 | 651 |
| 34 | EURObservational Research Programme: regional differences and 1‐year follow‐up results of the Heart Failure Pilot Survey (ESC‐HF Pilot) | European Journal of Heart Failure | 2013 | 645 |
| 35 | European Stroke Organisation (ESO) Guidelines for the Management of Spontaneous Intracerebral Hemorrhage | International Journal of Stroke | 2014 | 638 |
| 36 | Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study | Diabetologia | 2020 | 638 |
| 37 | Atypical and Malignant Solitary Fibrous Tumors in Extrathoracic Locations | American Journal of Surgical Pathology | 1998 | 628 |
| 38 | EANO guidelines for the diagnosis and treatment of meningiomas | Lancet Oncology, The | 2016 | 627 |
| 39 | Mechanisms of Action and Therapeutic Potential of Strontium in Bone | Calcified Tissue International | 2001 | 602 |
| 40 | Microcirculation in Hypertension | Circulation | 2001 | 564 |
| 41 | Expression of Interleukin-18 in Human Atherosclerotic Plaques and Relation to Plaque Instability | Circulation | 2001 | 555 |
| 42 | Myosin isoenzyme redistribution in chronic heart overload | Nature | 1979 | 552 |
| 43 | 2015 Gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative | Annals of the Rheumatic Diseases | 2015 | 545 |
| 44 | Effect of Heart Rate Control With Esmolol on Hemodynamic and Clinical Outcomes in Patients With Septic Shock | JAMA - Journal of the American Medical Association | 2013 | 542 |
| 45 | European Society of Cardiology Heart Failure Long‐Term Registry (ESC‐HF‐LT): 1‐year follow‐up outcomes and differences across regions | European Journal of Heart Failure | 2016 | 538 |
| 46 | Are hospitalized or ambulatory patients with heart failure treated in accordance with European Society of Cardiology guidelines? Evidence from 12 440 patients of the ESC Heart Failure Long‐Term Registry | European Journal of Heart Failure | 2013 | 533 |
| 47 | Endarterectomy Versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis (EVA-3S) trial: results up to 4 years from a randomised, multicentre trial | Lancet Neurology, The | 2008 | 531 |
| 48 | Platelet α-granules | Blood Reviews | 1993 | 529 |
| 49 | Prognostic Accuracy of Sepsis-3 Criteria for In-Hospital Mortality Among Patients With Suspected Infection Presenting to the Emergency Department | JAMA - Journal of the American Medical Association | 2017 | 529 |
| 50 | Increased myocardial NADPH oxidase activity in human heart failure | Journal of the American College of Cardiology | 2003 | 521 |
