| Global biodiversity scenarios for the year 2100 | Science | 2000 | 5.9K |
| Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set | Analytical Biochemistry | 2000 | 2.4K |
| A Nonparametric “Trim and Fill” Method of Accounting for Publication Bias in Meta-Analysis | Journal of the American Statistical Association | 2000 | 1.4K |
| Experimentation in Software Engineering | Kluwer International Series in Software Engineering | 2000 | 1.3K |
| Soil Structure and Organic Matter I. Distribution of Aggregate-Size Classes and Aggregate-Associated Carbon | Soil Science Society of America Journal | 2000 | 891 |
| Mechanisms controlling the function and life span of the corpus luteum | Physiological Reviews | 2000 | 699 |
| Long-term dynamics of pine and hardwood litter in contrasting environments: toward a global model of decomposition | Global Change Biology | 2000 | 608 |
| Mortality of sea lions along the central California coast linked to a toxic diatom bloom | Nature | 2000 | 595 |
| Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer diets | American Journal of Clinical Nutrition | 2000 | 529 |
| Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 529 |
| Management options for reducing CO2 emissions from agricultural soils | Biogeochemistry | 2000 | 525 |
| Estimation of protein secondary structure from circular dichroism spectra: inclusion of denatured proteins with native proteins in the analysis | Analytical Biochemistry | 2000 | 480 |
| Contribution of increasing CO2 and climate to carbon storage by ecosystems in the United States | Science | 2000 | 458 |
| The effect of market orientation on product innovation | Journal of the Academy of Marketing Science | 2000 | 436 |
| Contracts, norms, and plural form governance | Journal of the Academy of Marketing Science | 2000 | 433 |
| Arctic and boreal ecosystems of western North America as components of the climate system. | Global Change Biology | 2000 | 431 |
| Passive Transfer of Colostral Immunoglobulins in Calves | Journal of Veterinary Internal Medicine | 2000 | 424 |
| Induction of a bystander mutagenic effect of alpha particles in mammalian cells | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 414 |
| Crystal structure of a nucleosome core particle containing the variant histone H2A.Z | Nature Structural Biology | 2000 | 411 |
| The Asymmetric Total Synthesis of (+)- and (−)-Spirotryprostatin B | Journal of the American Chemical Society | 2000 | 395 |
| CLIMATE, HABITAT QUALITY, AND FITNESS IN NORTHERN SPOTTED OWL POPULATIONS IN NORTHWESTERN CALIFORNIA | Ecological Monographs | 2000 | 389 |
| Coupled Atmosphere–Biophysics–Hydrology Models for Environmental Modeling | Journal of Applied Meteorology and Climatology | 2000 | 387 |
| Molecular Dynamics Simulations of the Interior of Aqueous Reverse Micelles | Journal of Physical Chemistry B | 2000 | 385 |
| Integration-proficient plasmids for Pseudomonas aeruginosa: site-specific integration and use for engineering of reporter and expression strains | Plasmid | 2000 | 381 |
| Survey and summary: transcription by RNA polymerases I and III | Nucleic Acids Research | 2000 | 361 |
