| # | Title | Journal | Year | Citations |
|---|
| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 2 | Validation of the Insomnia Severity Index as an outcome measure for insomnia research | Sleep Medicine | 2001 | 5,399 |
| 3 | CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes | Science | 2007 | 4,956 |
| 4 | Single-Junction Organic Solar Cell with over 15% Efficiency Using Fused-Ring Acceptor with Electron-Deficient Core | Joule | 2019 | 4,052 |
| 5 | Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus | Arthritis and Rheumatism | 2012 | 3,838 |
| 6 | Allergic Rhinitis and its Impact on Asthma (ARIA) 2008* | Allergy: European Journal of Allergy and Clinical Immunology | 2008 | 3,827 |
| 7 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 8 | Thalamocortical oscillations in the sleeping and aroused brain | Science | 1993 | 3,328 |
| 9 | Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients | New England Journal of Medicine | 2019 | 3,312 |
| 10 | Starburst99: Synthesis Models for Galaxies with Active Star Formation | Astrophysical Journal, Supplement Series | 1999 | 3,279 |
| 11 | Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events | New England Journal of Medicine | 2008 | 3,155 |
| 12 | A comprehensive genetic map of the human genome based on 5,264 microsatellites | Nature | 1996 | 2,916 |
| 13 | The Insomnia Severity Index: Psychometric Indicators to Detect Insomnia Cases and Evaluate Treatment Response | Sleep | 2011 | 2,889 |
| 14 | Decision aids for people facing health treatment or screening decisions | The Cochrane Library | 2017 | 2,780 |
| 15 | Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma | New England Journal of Medicine | 2017 | 2,677 |
| 16 | Stenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis | New England Journal of Medicine | 2010 | 2,634 |
| 17 | Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE | Nature | 1994 | 2,471 |
| 18 | Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase | Cell | 1995 | 2,396 |
| 19 | The Theory of Planned Behavior: A Review of its Applications to Health-Related Behaviors | American Journal of Health Promotion | 1996 | 2,342 |
| 20 | An updated evolutionary classification of CRISPR–Cas systems | Nature Reviews Microbiology | 2015 | 2,081 |
| 21 | Evolution and classification of the CRISPR–Cas systems | Nature Reviews Microbiology | 2011 | 2,078 |
| 22 | Heteronuclear decoupling in rotating solids | Journal of Chemical Physics | 1995 | 2,064 |
| 23 | Terrestrial Gross Carbon Dioxide Uptake: Global Distribution and Covariation with Climate | Science | 2010 | 2,056 |
| 24 | The Varnes classification of landslide types, an update | Landslides | 2014 | 2,018 |
| 25 | Bacteriophage resistance mechanisms | Nature Reviews Microbiology | 2010 | 1,906 |
| 26 | Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers | JAMA - Journal of the American Medical Association | 2017 | 1,898 |
| 27 | The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA | Nature | 2010 | 1,897 |
| 28 | A Phase 3 Trial of Bevacizumab in Ovarian Cancer | New England Journal of Medicine | 2011 | 1,843 |
| 29 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 30 | Waist circumference and abdominal sagittal diameter: Best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women | American Journal of Cardiology | 1994 | 1,744 |
| 31 | A novel slow (< 1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components | Journal of Neuroscience | 1993 | 1,705 |
| 32 | BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain | Nature | 2005 | 1,690 |
| 33 | Sugar-Sweetened Beverages and Risk of Metabolic Syndrome and Type 2 Diabetes | Diabetes Care | 2010 | 1,648 |
| 34 | Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial | Lancet, The | 2019 | 1,625 |
| 35 | Ecological Impacts of Deer Overabundance | Annual Review of Ecology, Evolution, and Systematics | 2004 | 1,557 |
| 36 | Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions | Biochemical Journal | 1999 | 1,541 |
| 37 | Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis | New England Journal of Medicine | 2016 | 1,467 |
| 38 | Mindfulness-based therapy: A comprehensive meta-analysis | Clinical Psychology Review | 2013 | 1,446 |
| 39 | Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants | Nature Reviews Microbiology | 2020 | 1,427 |
| 40 | Basal Insulin and Cardiovascular and Other Outcomes in Dysglycemia | New England Journal of Medicine | 2012 | 1,426 |
| 41 | Vaccine hesitancy | Human Vaccines and Immunotherapeutics | 2013 | 1,419 |
| 42 | Effects of Rimonabant on Metabolic Risk Factors in Overweight Patients with Dyslipidemia | New England Journal of Medicine | 2005 | 1,350 |
| 43 | Application of Large Pore MCM-41 Molecular Sieves To Improve Pore Size Analysis Using Nitrogen Adsorption Measurements | Langmuir | 1997 | 1,345 |
| 44 | Toward a Rational Design of Poly(2,7-Carbazole) Derivatives for Solar Cells | Journal of the American Chemical Society | 2008 | 1,328 |
| 45 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 46 | The Mixed Methods Appraisal Tool (MMAT) version 2018 for information professionals and researchers | Education for Information | 2018 | 1,312 |
| 47 | Understanding Smart Cities: An Integrative Framework | Education for Information | 2012 | 1,306 |
| 48 | The Norway spruce genome sequence and conifer genome evolution | Nature | 2013 | 1,303 |
| 49 | FAST-TRACK: Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis) | Molecular Ecology | 2004 | 1,298 |
| 50 | Pulmonary rehabilitation for chronic obstructive pulmonary disease | The Cochrane Library | 2015 | 1,275 |
