| # | Title | Journal | Year | Citations |
|---|
| 1 | Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial | Lancet, The | 2002 | 2,331 |
| 2 | Nomenclature of monocytes and dendritic cells in blood | Blood | 2010 | 2,046 |
| 3 | Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study | Lancet, The | 2019 | 1,804 |
| 4 | Epidemiology and Risk Factors of Urothelial Bladder Cancer | European Urology | 2013 | 1,572 |
| 5 | A Randomized, Placebo-Controlled Trial of Zoledronic Acid in Patients With Hormone-Refractory Metastatic Prostate Carcinoma | Journal of the National Cancer Institute | 2002 | 1,557 |
| 6 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial | Lancet Oncology, The | 2010 | 1,477 |
| 7 | TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis | Nature Genetics | 2008 | 1,371 |
| 8 | Long-Term Angiographic Recurrences After Selective Endovascular Treatment of Aneurysms With Detachable Coils | Stroke | 2003 | 1,347 |
| 9 | Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases | JAMA - Journal of the American Medical Association | 2016 | 1,225 |
| 10 | Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study | Lancet, The | 2019 | 1,153 |
| 11 | Long-Term Efficacy of Zoledronic Acid for the Prevention of Skeletal Complications in Patients With Metastatic Hormone-Refractory Prostate Cancer | Journal of the National Cancer Institute | 2004 | 1,081 |
| 12 | Cushing's syndrome | Lancet, The | 2015 | 988 |
| 13 | Osteoarthritis, an inflammatory disease: Potential implication for the selection of new therapeutic targets | Arthritis and Rheumatism | 2001 | 953 |
| 14 | Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer | New England Journal of Medicine | 2018 | 947 |
| 15 | Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease | Journal of Crohn's and Colitis | 2014 | 804 |
| 16 | The role of cytokines in osteoarthritis pathophysiology | Biorheology | 2002 | 713 |
| 17 | Updated Nomogram Predicting Lymph Node Invasion in Patients with Prostate Cancer Undergoing Extended Pelvic Lymph Node Dissection: The Essential Importance of Percentage of Positive Cores | European Urology | 2012 | 594 |
| 18 | Autologous Hematopoietic Stem Cell Transplantation vs Intravenous Pulse Cyclophosphamide in Diffuse Cutaneous Systemic Sclerosis | JAMA - Journal of the American Medical Association | 2014 | 566 |
| 19 | Frailty in Older Adults Undergoing Aortic Valve Replacement | Journal of the American College of Cardiology | 2017 | 561 |
| 20 | Pathologic fractures correlate with reduced survival in patients with malignant bone disease | Cancer | 2007 | 559 |
| 21 | New CT Index to Quantify Arterial Obstruction in Pulmonary Embolism | American Journal of Roentgenology | 2001 | 551 |
| 22 | Estimating Survival in Patients With Lung Cancer and Brain Metastases | JAMA Oncology | 2017 | 543 |
| 23 | Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud's phenomenon to systemic sclerosis: A twenty‐year prospective study of 586 patients, with validation of proposed criteria for early systemic sclerosis | Arthritis and Rheumatism | 2008 | 507 |
| 24 | Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017 | European Urology | 2018 | 488 |
| 25 | Vascular access use and outcomes: an international perspective from the dialysis outcomes and practice patterns study | Nephrology Dialysis Transplantation | 2008 | 476 |
| 26 | Early identification of HCV genotype 1 patients responding to 24 weeks peginterferon α-2a (40 kd)/ribavirin therapy | Hepatology | 2006 | 469 |
| 27 | Drug-Eluting and Bare Nitinol Stents for the Treatment of Atherosclerotic Lesions in the Superficial Femoral Artery:Long-term Results From the SIROCCO Trial | Journal of Endovascular Therapy | 2006 | 468 |
| 28 | A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy | Brain | 2011 | 461 |
| 29 | Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study | Annals of Oncology | 2019 | 456 |
| 30 | Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: A randomized, double-blind, placebo-controlled trial | Arthritis and Rheumatism | 2003 | 452 |
| 31 | eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 447 |
| 32 | Lamivudine treatment for decompensated cirrhosis resulting from chronic hepatitis B | Hepatology | 2000 | 435 |
| 33 | Guidance on the use of bisphosphonates in solid tumours: recommendations of an international expert panel | Annals of Oncology | 2008 | 410 |
| 34 | Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial | Lancet, The | 2020 | 400 |
| 35 | Understanding polydrug use: review of heroin and cocaine co-use | Addiction | 2003 | 391 |
| 36 | Radiomics strategies for risk assessment of tumour failure in head-and-neck cancer | Scientific Reports | 2017 | 391 |
| 37 | Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study | Lancet HIV,the | 2017 | 379 |
| 38 | ERS statement on respiratory muscle testing at rest and during exercise | European Respiratory Journal | 2019 | 379 |
| 39 | Opiate substitution treatment and HIV transmission in people who inject drugs: systematic review and meta-analysis | BMJ, The | 2012 | 363 |
| 40 | β-Blockers in Congestive Heart Failure: A Bayesian Meta-Analysis | Annals of Internal Medicine | 2001 | 347 |
| 41 | Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs | Annals of the Rheumatic Diseases | 2003 | 346 |
| 42 | Impact of age, age at diagnosis and duration of diabetes on the risk of macrovascular and microvascular complications and death in type 2 diabetes | Diabetologia | 2014 | 346 |
| 43 | Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data | BMJ: British Medical Journal | 2017 | 346 |
| 44 | Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects | Journal of Allergy and Clinical Immunology | 2018 | 344 |
| 45 | Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: Results of the two-year multinational knee osteoarthritis structural arthritis study | Arthritis and Rheumatism | 2006 | 338 |
| 46 | Lapatinib as a component of neoadjuvant therapy for HER2-positive operable breast cancer (NSABP protocol B-41): an open-label, randomised phase 3 trial | Lancet Oncology, The | 2013 | 332 |
| 47 | Hypertension Canada’s 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children | Canadian Journal of Cardiology | 2020 | 324 |
| 48 | Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase | Arthritis and Rheumatism | 1998 | 318 |
| 49 | Consensus on diagnosis and management of Cushing's disease: a guideline update | Lancet Diabetes and Endocrinology,the | 2021 | 315 |
| 50 | Mechanisms of hypersensitivity in IBS and functional disorders | Neurogastroenterology and Motility | 2007 | 310 |
