| # | Title | Journal | Year | Citations |
|---|
| 1 | Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials | Lancet, The | 2014 | 1,971 |
| 2 | Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma | Molecular Cancer | 2006 | 1,550 |
| 3 | Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2 | Nature Genetics | 1996 | 1,092 |
| 4 | The mycobiota: interactions between commensal fungi and the host immune system | Nature Reviews Immunology | 2014 | 525 |
| 5 | Genome-wide Analyses Identify KIF5A as a Novel ALS Gene | Neuron | 2018 | 517 |
| 6 | Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 508 |
| 7 | C9orf72 is required for proper macrophage and microglial function in mice | Science | 2016 | 478 |
| 8 | Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease | Lancet Infectious Diseases, The | 2005 | 475 |
| 9 | Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double‐blind, placebo‐controlled study | Arthritis and Rheumatism | 2009 | 431 |
| 10 | Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis | Nature Neuroscience | 2014 | 398 |
| 11 | Subthalamic deep brain stimulation with a constant-current device in Parkinson's disease: an open-label randomised controlled trial | Lancet Neurology, The | 2012 | 354 |
| 12 | Elevated maternal cortisol early in pregnancy predicts third trimester levels of placental corticotropin releasing hormone (CRH): Priming the placental clock | Peptides | 2006 | 331 |
| 13 | Extended Rituximab (anti-CD20 monoclonal antibody) therapy for relapsed or refractory low-grade or follicular non-Hodgkin's lymphoma | Annals of Oncology | 1999 | 329 |
| 14 | Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation | Journal of Heart and Lung Transplantation | 2016 | 316 |
| 15 | Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human | Nature Genetics | 2000 | 304 |
| 16 | ATAXIA-TELANGIECTASIA | Pediatrics | 1958 | 294 |
| 17 | The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit | Nature Neuroscience | 2013 | 284 |
| 18 | The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative | Nature Reviews Neurology | 2016 | 274 |
| 19 | Pattern of perceived stress and anxiety in pregnancy predicts preterm birth. | Health Psychology | 2008 | 270 |
| 20 | Using the National Institutes of Health Stroke Scale | Stroke | 2017 | 261 |
| 21 | Commensal Fungi in Health and Disease | Cell Host and Microbe | 2017 | 258 |
| 22 | Angiogenesis in Endocrine Tumors | Endocrine Reviews | 2003 | 251 |
| 23 | C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD | Neuron | 2015 | 249 |
| 24 | RIGOR Guidelines: Escalating STAIR and STEPS for Effective Translational Research | Translational Stroke Research | 2013 | 240 |
| 25 | Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features | Cancer Research | 2001 | 238 |
| 26 | Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data | Lancet Neurology, The | 2018 | 229 |
| 27 | TREM2Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis | JAMA Neurology | 2014 | 221 |
| 28 | Assessment of Sinus Node Function in Patients with the Sick Sinus Syndrome | Circulation | 1972 | 220 |
| 29 | Revisiting Cerebral Postischemic Reperfusion Injury: New Insights in Understanding Reperfusion Failure, Hemorrhage, and Edema | International Journal of Stroke | 2015 | 204 |
| 30 | COVID‐19–associated Guillain‐Barré syndrome: The early pandemic experience | Muscle and Nerve | 2020 | 196 |
| 31 | Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: Contrasting effects of HLA-DR3 and the shared epitope alleles | Arthritis and Rheumatism | 2005 | 194 |
| 32 | Effects of Alteplase for Acute Stroke on the Distribution of Functional Outcomes | Stroke | 2016 | 193 |
| 33 | Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (PATH): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet Neurology, The | 2018 | 193 |
| 34 | Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis | Lancet Neurology, The | 2016 | 187 |
| 35 | MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A | Science | 2018 | 187 |
| 36 | Persistently active neurons in human medial frontal and medial temporal lobe support working memory | Nature Neuroscience | 2017 | 185 |
| 37 | Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations | Modern Pathology | 2015 | 180 |
| 38 | A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy? | Expert Opinion on Pharmacotherapy | 2010 | 179 |
| 39 | European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force—Second revision | Journal of the Peripheral Nervous System | 2021 | 176 |
| 40 | TDP-43 activates microglia through NF-κB and NLRP3 inflammasome | Experimental Neurology | 2015 | 174 |
| 41 | The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status | Genes and Immunity | 2005 | 173 |
| 42 | Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes | Annals of Neurology | 2015 | 171 |
| 43 | Temporary Emergency Guidance to US Stroke Centers During the Coronavirus Disease 2019 (COVID-19) Pandemic | Stroke | 2020 | 169 |
| 44 | Expression of ataxin-2 in brains from normal individuals and patients with Alzheimer's disease and spinocerebellar ataxia 2 | Annals of Neurology | 1999 | 161 |
| 45 | Current and future strategies for the treatment of malignant brain tumors | Annals of Neurology | 2003 | 160 |
| 46 | AWARE—AWAreness during REsuscitation—A prospective study | Resuscitation | 2014 | 157 |
| 47 | ARTERIO-VENOUS ANASTOMOSES IN LIVER, SPLEEN, AND LUNGS | American Journal of Physiology | 1947 | 153 |
| 48 | Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis | Tissue Antigens | 2007 | 153 |
| 49 | European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force—Second revision | European Journal of Neurology | 2021 | 153 |
| 50 | Interobserver and Intraobserver Variability of a Two-tier System for Grading Ovarian Serous Carcinoma | American Journal of Surgical Pathology | 2007 | 152 |
