| # | Title | Journal | Year | Citations |
|---|
| 1 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 9,397 |
| 2 | Computer "Experiments" on Classical Fluids. I. Thermodynamical Properties of Lennard-Jones Molecules | Physical Review | 1967 | 7,486 |
| 3 | An integrated map of genetic variation from 1,092 human genomes | Nature | 2012 | 7,199 |
| 4 | The Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents | Pediatrics | 2004 | 4,715 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 6 | Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma | New England Journal of Medicine | 2017 | 3,865 |
| 7 | Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes | New England Journal of Medicine | 2014 | 3,474 |
| 8 | Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies | Epilepsia | 2010 | 3,400 |
| 9 | Catastrophic cascade of failures in interdependent networks | Nature | 2010 | 3,326 |
| 10 | New Equations to Estimate GFR in Children with CKD | Journal of the American Society of Nephrology: JASN | 2009 | 2,853 |
| 11 | Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock | New England Journal of Medicine | 1999 | 2,596 |
| 12 | Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications | New England Journal of Medicine | 1988 | 2,347 |
| 13 | The adipocyte-secreted protein Acrp30 enhances hepatic insulin action | Nature Medicine | 2001 | 2,334 |
| 14 | Flow patterns around heart valves: A numerical method | Journal of Computational Physics | 1972 | 2,186 |
| 15 | A new algorithm for Monte Carlo simulation of Ising spin systems | Journal of Computational Physics | 1975 | 2,031 |
| 16 | Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions | Journal of Lipid Research | 1970 | 1,973 |
| 17 | Migraine prevalence, disease burden, and the need for preventive therapy | Neurology | 2007 | 1,943 |
| 18 | A hierarchical approach to all-atom protein loop prediction | Proteins: Structure, Function and Bioinformatics | 2004 | 1,874 |
| 19 | Nasal CPAP or Intubation at Birth for Very Preterm Infants | New England Journal of Medicine | 2008 | 1,704 |
| 20 | Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia | New England Journal of Medicine | 2012 | 1,688 |
| 21 | Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders | Pharmacogenetics and Genomics | 1996 | 1,681 |
| 22 | Effect of Dialysis Dose and Membrane Flux in Maintenance Hemodialysis | New England Journal of Medicine | 2002 | 1,664 |
| 23 | Viscous Liquids and the Glass Transition. II. Secondary Relaxations in Glasses of Rigid Molecules | Journal of Chemical Physics | 1970 | 1,645 |
| 24 | Leisure Activities and the Risk of Dementia in the Elderly | New England Journal of Medicine | 2003 | 1,584 |
| 25 | Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer | New England Journal of Medicine | 2018 | 1,558 |
| 26 | Evaluating storage, retention, and retrieval in disordered memory and learning | Neurology | 1974 | 1,544 |
| 27 | New use of BCG for recombinant vaccines | Nature | 1991 | 1,467 |
| 28 | Guidelines for Diagnosis, Treatment, and Prevention of Clostridium difficile Infections | American Journal of Gastroenterology | 2013 | 1,413 |
| 29 | Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments | Virology | 2010 | 1,377 |
| 30 | Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane | Journal of Biological Chemistry | 1998 | 1,375 |
| 31 | Viscous Liquids and the Glass Transition: A Potential Energy Barrier Picture | Journal of Chemical Physics | 1969 | 1,366 |
| 32 | The Obese Without Cardiometabolic Risk Factor Clustering and the Normal Weight With Cardiometabolic Risk Factor Clustering | Archives of Internal Medicine | 2008 | 1,340 |
| 33 | Integrin signalling during tumour progression | Nature Reviews Molecular Cell Biology | 2004 | 1,317 |
| 34 | Zidovudine in Asymptomatic Human Immunodeficiency Virus Infection | New England Journal of Medicine | 1990 | 1,312 |
| 35 | Lexical access in aphasic and nonaphasic speakers. | Psychological Review | 1997 | 1,270 |
| 36 | Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein | Nature Genetics | 2000 | 1,254 |
| 37 | Essential role of mouse telomerase in highly proliferative organs | Nature | 1998 | 1,195 |
| 38 | Understanding the phase-change mechanism of rewritable optical media | Nature Materials | 2004 | 1,193 |
| 39 | Hydrogen‐Evolution Catalysts Based on Non‐Noble Metal Nickel–Molybdenum Nitride Nanosheets | Angewandte Chemie - International Edition | 2012 | 1,174 |
| 40 | Effect of Amlodipine on Morbidity and Mortality in Severe Chronic Heart Failure | New England Journal of Medicine | 1996 | 1,141 |
| 41 | Ebola virus entry requires the cholesterol transporter Niemann–Pick C1 | Nature | 2011 | 1,127 |
| 42 | Prevalence of Migraine Headache in the United States | JAMA - Journal of the American Medical Association | 1992 | 1,097 |
| 43 | Exact Solution of Generalized Percus-Yevick Equation for a Mixture of Hard Spheres | Physical Review | 1964 | 1,094 |
| 44 | Predictors of Relapse Following Response From a First Episode of Schizophrenia or Schizoaffective Disorder | Archives of General Psychiatry | 1999 | 1,093 |
| 45 | Effects of Medical Therapies on Retinopathy Progression in Type 2 Diabetes | New England Journal of Medicine | 2010 | 1,091 |
| 46 | An Oscillatory Hierarchy Controlling Neuronal Excitability and Stimulus Processing in the Auditory Cortex | Journal of Neurophysiology | 2005 | 1,086 |
| 47 | A Randomized Trial of Adenotonsillectomy for Childhood Sleep Apnea | New England Journal of Medicine | 2013 | 1,085 |
| 48 | Computer "Experiments" on Classical Fluids. II. Equilibrium Correlation Functions | Physical Review | 1968 | 1,082 |
| 49 | Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis | Endocrinology | 2003 | 1,077 |
| 50 | ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism | Trends in Endocrinology and Metabolism | 2002 | 1,069 |
