| # | Title | Journal | Year | Citations |
|---|
| 1 | Analysis of protein-coding genetic variation in 60,706 humans | Nature | 2016 | 9,051 |
| 2 | Planck2015 results | Astronomy and Astrophysics | 2016 | 8,344 |
| 3 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 4 | UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age | PLoS Medicine | 2015 | 6,753 |
| 5 | GW170817: Observation of Gravitational Waves from a Binary Neutron Star Inspiral | Physical Review Letters | 2017 | 6,413 |
| 6 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 7 | Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids | Current Protocols in Cell Biology | 2006 | 4,140 |
| 8 | Antiseptics and Disinfectants: Activity, Action, and Resistance | Clinical Microbiology Reviews | 1999 | 3,661 |
| 9 | Process evaluation of complex interventions: Medical Research Council guidance | BMJ, The | 2015 | 3,602 |
| 10 | Gold Catalysis | Angewandte Chemie - International Edition | 2006 | 3,254 |
| 11 | MutationTaster2: mutation prediction for the deep-sequencing age | Nature Methods | 2014 | 3,203 |
| 12 | The dawning era of polymer therapeutics | Nature Reviews Drug Discovery | 2003 | 2,963 |
| 13 | Burden and consequences of child maltreatment in high-income countries | Lancet, The | 2009 | 2,901 |
| 14 | Molpro: a general‐purpose quantum chemistry program package | Wiley Interdisciplinary Reviews: Computational Molecular Science | 2012 | 2,852 |
| 15 | Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease | Nature Genetics | 2009 | 2,697 |
| 16 | Shared Decision Making: A Model for Clinical Practice | Journal of General Internal Medicine | 2012 | 2,681 |
| 17 | Gut microbiota composition correlates with diet and health in the elderly | Nature | 2012 | 2,618 |
| 18 | Geochemical fingerprinting of oceanic basalts with applications to ophiolite classification and the search for Archean oceanic crust | Lithos | 2008 | 2,568 |
| 19 | EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent | European Urology | 2017 | 2,497 |
| 20 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study | Lancet Infectious Diseases, The | 2010 | 2,485 |
| 21 | TREM2 Variants in Alzheimer's Disease | New England Journal of Medicine | 2013 | 2,385 |
| 22 | How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology | European Heart Journal | 2007 | 2,302 |
| 23 | Mechanochemistry: opportunities for new and cleaner synthesis | Chemical Society Reviews | 2012 | 2,281 |
| 24 | Synaptic, transcriptional and chromatin genes disrupted in autism | Nature | 2014 | 2,254 |
| 25 | Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice | Nature Cell Biology | 2014 | 2,241 |
| 26 | A flat Universe from high-resolution maps of the cosmic microwave background radiation | Nature | 2000 | 2,232 |
| 27 | Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression | Nature Genetics | 2018 | 2,224 |
| 28 | The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research | PLoS Biology | 2020 | 2,209 |
| 29 | 10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer | New England Journal of Medicine | 2016 | 2,101 |
| 30 | Characterization of a New Metallo-β-Lactamase Gene, bla NDM-1 , and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India | Antimicrobial Agents and Chemotherapy | 2009 | 2,065 |
| 31 | White matter integrity, fiber count, and other fallacies: The do's and don'ts of diffusion MRI | NeuroImage | 2013 | 2,042 |
| 32 | Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and Postpartum | Thyroid | 2011 | 2,014 |
| 33 | Solvent-Free Oxidation of Primary Alcohols to Aldehydes Using Au-Pd/TiO2 Catalysts | Science | 2006 | 1,976 |
| 34 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 35 | The UKIRT Infrared Deep Sky Survey (UKIDSS) | Monthly Notices of the Royal Astronomical Society | 2007 | 1,940 |
| 36 | A manifesto for reproducible science | Nature Human Behaviour | 2017 | 1,870 |
| 37 | Episodic memory, amnesia, and the hippocampal–anterior thalamic axis | Behavioral and Brain Sciences | 1999 | 1,862 |
| 38 | Polymer conjugates as anticancer nanomedicines | Nature Reviews Cancer | 2006 | 1,828 |
| 39 | IL-6 as a keystone cytokine in health and disease | Nature Immunology | 2015 | 1,825 |
| 40 | International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care | Human Reproduction | 2007 | 1,819 |
| 41 | 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum | Thyroid | 2017 | 1,811 |
| 42 | EGFR and cancer prognosis | European Journal of Cancer | 2001 | 1,791 |
| 43 | The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration | Survey of Ophthalmology | 2000 | 1,779 |
| 44 | Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease | Nature Genetics | 2011 | 1,708 |
| 45 | FSP1 is a glutathione-independent ferroptosis suppressor | Nature | 2019 | 1,624 |
| 46 | GW170814: A Three-Detector Observation of Gravitational Waves from a Binary Black Hole Coalescence | Physical Review Letters | 2017 | 1,600 |
| 47 | Depression in adolescence | Lancet, The | 2012 | 1,593 |
| 48 | Whole-genome analyses resolve early branches in the tree of life of modern birds | Science | 2014 | 1,583 |
| 49 | Polymers of intrinsic microporosity (PIMs): organic materials for membrane separations, heterogeneous catalysis and hydrogen storage | Chemical Society Reviews | 2006 | 1,545 |
| 50 | EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer—2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent | European Urology | 2021 | 1,545 |
