| # | Title | Journal | Year | Citations |
|---|
| 1 | Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells | Nature | 2013 | 3,901 |
| 2 | Bifidobacteria can protect from enteropathogenic infection through production of acetate | Nature | 2011 | 1,836 |
| 3 | Dopaminergic Loss and Inclusion Body Formation in -Synuclein Mice: Implications for Neurodegenerative Disorders | Science | 2000 | 1,691 |
| 4 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 | JAMA Oncology | 2019 | 1,691 |
| 5 | PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance | Molecular Cell | 1999 | 1,281 |
| 6 | Interpreting Diagnostic Tests for SARS-CoV-2 | JAMA - Journal of the American Medical Association | 2020 | 1,276 |
| 7 | Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome | Nature Genetics | 2010 | 1,238 |
| 8 | Genome-wide analysis of mammalian promoter architecture and evolution | Nature Genetics | 2006 | 1,201 |
| 9 | Non-homologous DNA end joining and alternative pathways to double-strand break repair | Nature Reviews Molecular Cell Biology | 2017 | 1,152 |
| 10 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer | International Journal of Clinical Oncology | 2020 | 1,123 |
| 11 | ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation | Nature | 2012 | 1,035 |
| 12 | Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine | Muscle and Nerve | 1995 | 1,006 |
| 13 | Type 2C protein phosphatases directly regulate abscisic acid-activated protein kinases in Arabidopsis | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 980 |
| 14 | The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014) | Hypertension Research | 2014 | 962 |
| 15 | Histone Deimination Antagonizes Arginine Methylation | Cell | 2004 | 744 |
| 16 | Intrahepatic Cholangiocarcinoma | Annals of Surgery | 2008 | 729 |
| 17 | Duration of Adjuvant Chemotherapy for Stage III Colon Cancer | New England Journal of Medicine | 2018 | 699 |
| 18 | A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes | Nature | 1998 | 644 |
| 19 | The PAR-aPKC system: lessons in polarity | Journal of Cell Science | 2006 | 632 |
| 20 | Standard steroid treatment for autoimmune pancreatitis | Gut | 2009 | 630 |
| 21 | In vitro production of functional sperm in cultured neonatal mouse testes | Nature | 2011 | 630 |
| 22 | Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease Than Transient Elastography | Gastroenterology | 2016 | 628 |
| 23 | Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties | Hepatology | 2006 | 621 |
| 24 | Effects of resistance exercise combined with moderate vascular occlusion on muscular function in humans | Journal of Applied Physiology | 2000 | 615 |
| 25 | S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex | Nature | 2003 | 614 |
| 26 | Role of Cell Surface Metalloprotease Mt1-Mmp in Epithelial Cell Migration over Laminin-5 | Journal of Cell Biology | 2000 | 596 |
| 27 | Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function | Archives of Biochemistry and Biophysics | 2018 | 586 |
| 28 | TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines | Nature | 2008 | 551 |
| 29 | Randomized Phase III Study of Gemcitabine Plus S-1, S-1 Alone, or Gemcitabine Alone in Patients With Locally Advanced and Metastatic Pancreatic Cancer in Japan and Taiwan: GEST Study | Journal of Clinical Oncology | 2013 | 548 |
| 30 | Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response | Nature | 2009 | 544 |
| 31 | Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice | Journal of Clinical Investigation | 2002 | 539 |
| 32 | Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinoma | Journal of Hepatology | 2015 | 538 |
| 33 | DLB and PDD boundary issues: Diagnosis, treatment, molecular pathology, and biomarkers | Neurology | 2007 | 515 |
| 34 | Multiple wheat genomes reveal global variation in modern breeding | Nature | 2020 | 513 |
| 35 | Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus | Nature | 2015 | 496 |
| 36 | Encephalitis and Encephalopathy Associated with an Influenza Epidemic in Japan | Clinical Infectious Diseases | 2002 | 493 |
| 37 | Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices | Cell | 1994 | 486 |
| 38 | Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci | Nature Genetics | 2010 | 476 |
| 39 | Arabidopsis Transcriptome Analysis under Drought, Cold, High-Salinity and ABA Treatment Conditions using a Tiling Array | Plant and Cell Physiology | 2008 | 475 |
| 40 | Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction | Journal of Experimental Medicine | 2005 | 446 |
| 41 | Randomized, Open-Label, Phase III Study Comparing Irinotecan With Paclitaxel in Patients With Advanced Gastric Cancer Without Severe Peritoneal Metastasis After Failure of Prior Combination Chemotherapy Using Fluoropyrimidine Plus Platinum: WJOG 4007 Trial | Journal of Clinical Oncology | 2013 | 439 |
| 42 | Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity | Nature | 2007 | 435 |
| 43 | Structural and Transcriptional Analysis of the Self-Incompatibility Locus of Almond: Identification of a Pollen-Expressed F-Box Gene with Haplotype-Specific Polymorphism | Plant Cell | 2003 | 422 |
| 44 | Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ | Nature | 2002 | 400 |
| 45 | Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial | Lancet Oncology, The | 2017 | 398 |
| 46 | Intercellular junctions and cellular polarity: the PAR–aPKC complex, a conserved core cassette playing fundamental roles in cell polarity | Current Opinion in Cell Biology | 2001 | 397 |
| 47 | Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin | Arthritis Research | 2004 | 397 |
| 48 | De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood | Nature Genetics | 2013 | 396 |
| 49 | Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases | Journal of Neuroimmunology | 2002 | 394 |
| 50 | Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene | Nature Genetics | 2001 | 376 |
