| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Descending control of pain | Progress in Neurobiology | 2002 | 2,567 |
| 2 | iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics | Lancet Oncology, The | 2017 | 1,733 |
| 3 | The induction of pain: an integrative review | Progress in Neurobiology | 1999 | 1,527 |
| 4 | AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice | Cell Metabolism | 2011 | 1,410 |
| 5 | RECIST 1.1—Update and clarification: From the RECIST committee | European Journal of Cancer | 2016 | 1,251 |
| 6 | Functional and physical interaction between Bcl-XL and a BH3-like domain in Beclin-1 | EMBO Journal | 2007 | 1,009 |
| 7 | Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy | Nature Reviews Drug Discovery | 2012 | 1,002 |
| 8 | Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy | Nature Reviews Drug Discovery | 2012 | 1,002 |
| 9 | The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models | Nature | 2016 | 861 |
| 10 | The neurobiology and control of anxious states | Progress in Neurobiology | 2003 | 819 |
| 11 | A dynamic COVID-19 immune signature includes associations with poor prognosis | Nature Medicine | 2020 | 812 |
| 12 | International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels | Pharmacological Reviews | 2003 | 743 |
| 13 | EDHF: bringing the concepts together | Trends in Pharmacological Sciences | 2002 | 733 |
| 14 | Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture) | American Journal of Physiology - Heart and Circulatory Physiology | 2006 | 673 |
| 15 | Endothelial dysfunction and vascular disease - a 30th anniversary update | Acta Physiologica | 2017 | 670 |
| 16 | Endothelial dysfunction and vascular disease | Acta Physiologica | 2009 | 644 |
| 17 | Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system | Nature Reviews Drug Discovery | 2009 | 605 |
| 18 | International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology | Pharmacological Reviews | 2003 | 554 |
| 19 | Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure | Nature Communications | 2020 | 554 |
| 20 | Overview of Nomenclature of Nuclear Receptors | Pharmacological Reviews | 2006 | 550 |
| 21 | Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing | Nature Reviews Drug Discovery | 2020 | 521 |
| 22 | Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis | Arthritis and Rheumatism | 2006 | 512 |
| 23 | Identification of the Melatonin-binding SiteMT 3 as the Quinone Reductase 2 | Journal of Biological Chemistry | 2000 | 503 |
| 24 | International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors | Pharmacological Reviews | 2010 | 499 |
| 25 | Comparison of the Effect of Denosumab and Alendronate on BMD and Biochemical Markers of Bone Turnover in Postmenopausal Women With Low Bone Mass: A Randomized, Blinded, Phase 3 Trial | Journal of Bone and Mineral Research | 2009 | 493 |
| 26 | The Novel Melatonin Agonist Agomelatine (S20098) Is an Antagonist at 5-Hydroxytryptamine2C Receptors, Blockade of Which Enhances the Activity of Frontocortical Dopaminergic and Adrenergic Pathways | Journal of Pharmacology and Experimental Therapeutics | 2003 | 488 |
| 27 | Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application | | 2006 | 485 |
| 28 | Antibacterial Effects of the Essential Oils of Commonly Consumed Medicinal Herbs Using an In Vitro Model | Molecules | 2010 | 466 |
| 29 | International Union of Pharmacology. XLVI. G Protein-Coupled Receptor List | Pharmacological Reviews | 2005 | 465 |
| 30 | Antianginal and Antiischemic Effects of Ivabradine, an I f Inhibitor, in Stable Angina | Circulation | 2003 | 451 |
| 31 | Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double‐blind, placebo‐controlled study | Arthritis Care and Research: the Official Journal of the Arthritis Health Professions Association | 2009 | 443 |
| 32 | Efficacy of Bazedoxifene in Reducing New Vertebral Fracture Risk in Postmenopausal Women With Osteoporosis: Results From a 3-Year, Randomized, Placebo-, and Active-Controlled Clinical Trial | Journal of Bone and Mineral Research | 2008 | 441 |
| 33 | Differential Actions of Antiparkinson Agents at Multiple Classes of Monoaminergic Receptor. I. A Multivariate Analysis of the Binding Profiles of 14 Drugs at 21 Native and Cloned Human Receptor Subtypes | Journal of Pharmacology and Experimental Therapeutics | 2002 | 436 |
| 34 | Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors | Nature Medicine | 2009 | 432 |
| 35 | Electronic health records to facilitate clinical research | Clinical Research in Cardiology | 2017 | 426 |
| 36 | Endothelium-Derived Hyperpolarizing Factor | Arteriosclerosis, Thrombosis, and Vascular Biology | 2006 | 423 |
| 37 | Altering the course of schizophrenia: progress and perspectives | Nature Reviews Drug Discovery | 2016 | 421 |
| 38 | Effects of teriparatide versus alendronate for treating glucocorticoid‐induced osteoporosis: Thirty‐six–month results of a randomized, double‐blind, controlled trial | Arthritis and Rheumatism | 2009 | 415 |
| 39 | Classification of current anticancer immunotherapies | Oncotarget | 2014 | 404 |
| 40 | Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing | Nature Reviews Drug Discovery | 2018 | 401 |
| 41 | Endothelium-Dependent Hyperpolarization | Circulation | 1995 | 391 |
| 42 | Incidence and epidemiology of heart failure | Heart Failure Reviews | 2000 | 382 |
| 43 | Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma | Gut | 2017 | 371 |
| 44 | Myristoylation | Cellular Signalling | 1997 | 366 |
| 45 | Safety and efficacy of rituximab in systemic lupus erythematosus: Results from 136 patients from the French autoimmunity and rituximab registry | Arthritis and Rheumatism | 2010 | 359 |
| 46 | κ-Opioid receptors and analgesia | Trends in Pharmacological Sciences | 1990 | 355 |
| 47 | Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man | Xenobiotica | 2000 | 336 |
| 48 | An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats | Journal of Bone and Mineral Research | 1993 | 336 |
| 49 | Quality of Life in Sarcopenia and Frailty | Calcified Tissue International | 2013 | 323 |
| 50 | Agomelatine, the first melatonergic antidepressant: discovery, characterization and development | Nature Reviews Drug Discovery | 2010 | 320 |
