| # | Title | Journal | Year | Citations |
|---|
| 1 | Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation | Journal of Experimental Medicine | 2000 | 4,394 |
| 2 | PD-L2 is a second ligand for PD-1 and inhibits T cell activation | Nature Immunology | 2001 | 2,504 |
| 3 | Extended-Spectrum β-Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat | Clinical Microbiology Reviews | 2001 | 2,099 |
| 4 | Comparative distribution of estrogen receptor-? and -? mRNA in the rat central nervous system | Clinical Microbiology Reviews | 1997 | 2,033 |
| 5 | Mutations in SDHD, a Mitochondrial Complex II Gene, in Hereditary Paraganglioma | Science | 2000 | 1,554 |
| 6 | π-Stacking Interactions | Journal of Biological Chemistry | 1998 | 1,001 |
| 7 | Modulation of A-type potassium channels by a family of calcium sensors | Nature | 2000 | 914 |
| 8 | Remission rates during treatment with venlafaxine or selective serotonin reuptake inhibitors | British Journal of Psychiatry | 2001 | 750 |
| 9 | Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system | British Journal of Psychiatry | 1999 | 660 |
| 10 | Society for Healthcare Epidemiology of America and Infectious Diseases Society of America Joint Committee on the Prevention of Antimicrobial Resistance: Guidelines for the Prevention of Antimicrobial Resistance in Hospitals | Clinical Infectious Diseases | 1997 | 625 |
| 11 | Sirolimus: its discovery, biological properties, and mechanism of action | Transplantation Proceedings | 2003 | 601 |
| 12 | Transcription Profiling-Based Identification of Staphylococcus aureus Genes Regulated by the agr and/or sarA Loci | Journal of Bacteriology | 2001 | 589 |
| 13 | Recommendations for the design and optimization of immunoassays used in the detection of host antibodies against biotechnology products | Journal of Immunological Methods | 2004 | 576 |
| 14 | Prevention of HIV-1 infection in chimpanzees by gpl20 V3 domain-specific monoclonal antibody | Nature | 1992 | 547 |
| 15 | Gemtuzumab Ozogamicin, A Potent and Selective Anti-CD33 Antibody−Calicheamicin Conjugate for Treatment of Acute Myeloid Leukemia | Bioconjugate Chemistry | 2002 | 506 |
| 16 | Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana | Microbiology (United Kingdom) | 1996 | 498 |
| 17 | Combinatorial chemoprevention of intestinal neoplasia | Nature Medicine | 2000 | 495 |
| 18 | Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice | Journal of Clinical Investigation | 2001 | 473 |
| 19 | Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist | Behavioural Brain Research | 1995 | 461 |
| 20 | A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2. | Journal of Experimental Medicine | 1996 | 455 |
| 21 | The Cell Cycle: A Review | Veterinary Pathology | 1998 | 453 |
| 22 | Estradiol Modulates bcl-2 in Cerebral Ischemia: A Potential Role for Estrogen Receptors | Journal of Neuroscience | 1999 | 435 |
| 23 | Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the foss of an outer membrane protein | Antimicrobial Agents and Chemotherapy | 1997 | 431 |
| 24 | Distribution of estrogen receptor ? immunoreactivity in the rat central nervous system | Journal of Comparative Neurology | 2001 | 424 |
| 25 | Crystal structure of the wide-spectrum binuclear zinc β-lactamase from Bacteroides fragilis | Structure | 1996 | 402 |
| 26 | mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. | Endocrine-Related Cancer | 2001 | 388 |
| 27 | Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains. | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 383 |
| 28 | The Estrogen Receptor β Subtype: A Novel Mediator of Estrogen Action in Neuroendocrine Systems | Frontiers in Neuroendocrinology | 1998 | 382 |
| 29 | βSubunits Promote K+ Channel Surface Expression through Effects Early in Biosynthesis | Neuron | 1996 | 375 |
| 30 | Carbapenem-hydrolyzing beta-lactamases | Antimicrobial Agents and Chemotherapy | 1997 | 369 |
| 31 | Channeling of Substrates and Intermediates in Enzyme-Catalyzed Reactions | Annual Review of Biochemistry | 2001 | 352 |
| 32 | TRAM-1, A Novel 160-kDa Thyroid Hormone Receptor Activator Molecule, Exhibits Distinct Properties from Steroid Receptor Coactivator-1 | Journal of Biological Chemistry | 1997 | 347 |
| 33 | Relief of vasomotor symptoms and vaginal atrophy with lower doses of conjugated equine estrogens and medroxyprogesterone acetate | Fertility and Sterility | 2001 | 339 |
| 34 | Haloperidol, lorazepam, or both for psychotic agitation? A multicenter, prospective, double-blind, emergency department study | American Journal of Emergency Medicine | 1997 | 336 |
| 35 | Chronic musculoskeletal pain and depressive symptoms in the national health and nutrition examination I. Epidemiologic follow-up study | Pain | 1993 | 315 |
| 36 | Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 302 |
| 37 | Automated analysis of protein NMR assignments using methods from artificial intelligence | Journal of Molecular Biology | 1997 | 292 |
| 38 | Chronic musculoskeletal pain and depressive symptoms in the general population. An analysis of the 1st National Health and Nutrition Examination Survey data | Pain | 1990 | 283 |
| 39 | Therapy of hyponatremia in cirrhosis with a vasopressin receptor antagonist: A randomized double-blind multicenter trial | Gastroenterology | 2003 | 280 |
| 40 | The distribution of estrogen receptor-β mRNA in the rat hypothalamus | Steroids | 1996 | 277 |
| 41 | New Potent Antihyperglycemic Agents in db/db Mice: Synthesis and Structure−Activity Relationship Studies of (4-Substituted benzyl)(trifluoromethyl)pyrazoles and -pyrazolones | Journal of Medicinal Chemistry | 1996 | 275 |
| 42 | Association and Colocalization of the Kvβ1 and Kvβ2 β-Subunits with Kv1 α-Subunits in Mammalian Brain K+Channel Complexes | Journal of Neuroscience | 1997 | 264 |
| 43 | Economic Burden of Postoperative Ileus Associated With Colectomy in the United States | Journal of Managed Care Pharmacy | 2009 | 258 |
| 44 | Comparative distribution of estrogen receptor-α (ER-α) and β (ER-β) mRNA in the rat pituitary, gonad, and reproductive tract | Steroids | 1998 | 256 |
| 45 | Channel specificity in antiarrhythmic drug action. Mechanism of potassium channel block and its role in suppressing and aggravating cardiac arrhythmias. | Circulation | 1990 | 253 |
| 46 | Detection of Estrogen Receptor-β Messenger Ribonucleic Acid and 125I-Estrogen Binding Sites in Luteinizing Hormone-Releasing Hormone Neurons of the Rat Brain | Endocrinology | 2000 | 253 |
| 47 | 6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-2) Tyrosine Kinases with Enhanced Antitumor Activity | Journal of Medicinal Chemistry | 2001 | 251 |
| 48 | Phospholipase A2 enzymes: regulation and inhibition | Trends in Pharmacological Sciences | 1993 | 247 |
| 49 | Estrogen Receptor-β Immunoreactivity in Luteinizing Hormone-Releasing Hormone Neurons of the Rat Brain | Endocrinology | 2001 | 244 |
| 50 | Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells | Nature Medicine | 1999 | 237 |
