| # | Title | Journal | Year | Citations |
|---|
| 1 | Prevalence and burden of overactive bladder in the United States | World Journal of Urology | 2003 | 1,925 |
| 2 | Bioanalytical method validation--a revisit with a decade of progress | Pharmaceutical Research | 2000 | 1,423 |
| 3 | COX-2 is expressed in human pulmonary, colonic, and mammary tumors | Cancer | 2000 | 798 |
| 4 | aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation | Developmental Cell | 2002 | 779 |
| 5 | Rapid grid-based construction of the molecular surface and the use of induced surface charge to calculate reaction field energies: Applications to the molecular systems and geometric objects | Journal of Computational Chemistry | 2002 | 631 |
| 6 | Linezolid versus Vancomycin for the Treatment of Methicillin‐ResistantStaphylococcus aureusInfections | Clinical Infectious Diseases | 2002 | 626 |
| 7 | Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression | Nature | 2001 | 609 |
| 8 | Aldosterone induces a vascular inflammatory phenotype in the rat heart | American Journal of Physiology - Heart and Circulatory Physiology | 2002 | 553 |
| 9 | Oxazolidinone Structure–Activity Relationships Leading to Linezolid | Angewandte Chemie - International Edition | 2003 | 471 |
| 10 | Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats | Kidney International | 2003 | 463 |
| 11 | A comparison of latanoprost, bimatoprost, and travoprost in patients with elevated intraocular pressure: | American Journal of Ophthalmology | 2003 | 461 |
| 12 | Molecular Docking and High-Throughput Screening for Novel Inhibitors of Protein Tyrosine Phosphatase-1B | Journal of Medicinal Chemistry | 2002 | 453 |
| 13 | Linezolid for the Treatment of Multidrug‐Resistant, Gram‐Positive Infections: Experience from a Compassionate‐Use Program | Clinical Infectious Diseases | 2003 | 397 |
| 14 | Efficacy and safety of the cyclooxygenase 2 inhibitors parecoxib and valdecoxib in patients undergoing coronary artery bypass surgery | Journal of Thoracic and Cardiovascular Surgery | 2003 | 382 |
| 15 | Endocrine Dysfunction in Prader-Willi Syndrome: A Review with Special Reference to GH | Endocrine Reviews | 2001 | 356 |
| 16 | Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs | Journal of Orthopaedic Research | 2003 | 307 |
| 17 | Chemistry and Biochemistry of Type 2 Diabetes | Chemical Reviews | 2004 | 303 |
| 18 | Effects of celecoxib and rofecoxib on blood pressure and edema in patients ≥65 years of age with systemic hypertension and osteoarthritis | American Journal of Cardiology | 2002 | 298 |
| 19 | The Impact of Urinary Urgency and Frequency on Health-Related Quality of Life in Overactive Bladder: Results from a National Community Survey | Value in Health | 2004 | 297 |
| 20 | The prevalence of nocturia and its effect on health‐related quality of life and sleep in a community sample in the USA | BJU International | 2003 | 293 |
| 21 | Identification of a novel mitochondrial protein (“mitoNEET”) cross-linked specifically by a thiazolidinedione photoprobe | American Journal of Physiology - Endocrinology and Metabolism | 2004 | 292 |
| 22 | Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants | Arthritis and Rheumatism | 2002 | 281 |
| 23 | Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint | EMBO Journal | 2002 | 278 |
| 24 | Clinical Pharmacokinetics of Linezolid, a Novel Oxazolidinone Antibacterial | Clinical Pharmacokinetics | 2003 | 257 |
| 25 | Obesity and health-related quality of life: a cross-sectional analysis of the US population | International Journal of Obesity | 2003 | 250 |
| 26 | Biological markers for therapeutic trials in Alzheimer’s disease | Neurobiology of Aging | 2003 | 249 |
| 27 | Near-infrared spectral imaging for quality assurance of pharmaceutical products: Analysis of tablets to assess powder blend homogeneity | AAPS PharmSciTech | 2002 | 239 |
| 28 | The Pathophysiology of Aldosterone in the Cardiovascular System | Annals of the New York Academy of Sciences | 2002 | 238 |
| 29 | Inhibition of Mammalian Mitochondrial Protein Synthesis by Oxazolidinones | Antimicrobial Agents and Chemotherapy | 2006 | 233 |
| 30 | Estimated economic costs of overactive bladder in the United States | Urology | 2003 | 232 |
| 31 | Continuation of a randomized, double-blind, multicenter study of linezolid versus vancomycin in the treatment of patients with nosocomial pneumonia | Clinical Therapeutics | 2003 | 227 |
| 32 | Health-related quality of life among adults with symptoms of overactive bladder: results from a U.S. community-based survey | Urology | 2001 | 226 |
| 33 | Efficacy and tolerability of eplerenone and losartan in hypertensive black and white patients | Journal of the American College of Cardiology | 2003 | 214 |
| 34 | Celecoxib: A Specific COX-2 Inhibitor with Anticancer Properties | Cancer Control | 2002 | 207 |
| 35 | Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype | Neurobiology of Disease | 2003 | 206 |
| 36 | Pathophysiological effects of aldosterone in cardiovascular tissues | Trends in Endocrinology and Metabolism | 2001 | 200 |
| 37 | A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics | FASEB Journal | 2003 | 193 |
| 38 | Investigations into Biochemical Changes Due to Diurnal Variation and Estrus Cycle in Female Rats Using High-Resolution 1H NMR Spectroscopy of Urine and Pattern Recognition | Analytical Biochemistry | 2001 | 182 |
| 39 | ANALYSIS OF NOVEL DISEASE-RELATED GENES IN BRONCHIAL ASTHMA | Cytokine | 2002 | 181 |
| 40 | Worldwide Assessment of Linezolid's Clinical Safety and Tolerability: Comparator-Controlled Phase III Studies | Antimicrobial Agents and Chemotherapy | 2003 | 168 |
| 41 | Pharmacokinetics, metabolism, and excretion of linezolid following an oral dose of [(14)C]linezolid to healthy human subjects | Drug Metabolism and Disposition | 2001 | 168 |
| 42 | Psychometric evaluation of the 12-item short-form health survey (SF-12) in osteoarthritis and rheumatoid arthritis clinical trials | Clinical Therapeutics | 2001 | 167 |
| 43 | Oxazolidinone Resistance Mutations in 23S rRNA ofEscherichia coli Reveal the Central Region of Domain V as the Primary Site of Drug Action | Journal of Bacteriology | 2000 | 164 |
| 44 | A systematic literature review of the clinical and epidemiological burden of acute lymphoblastic leukaemia (ALL) | European Journal of Cancer Care | 2005 | 161 |
| 45 | Efficacy of eplerenone versus enalapril as monotherapy in systemic hypertension | American Journal of Cardiology | 2004 | 159 |
| 46 | Practical aspects of lyophilization using non-aqueous co-solvent systems | European Journal of Pharmaceutical Sciences | 2002 | 157 |
| 47 | Synthesis of (−)-PNU-286607 by Asymmetric Cyclization of Alkylidene Barbiturates | Journal of the American Chemical Society | 2009 | 156 |
| 48 | Synthesis of 8-Desbromohinckdentine A1 | Journal of the American Chemical Society | 2003 | 154 |
| 49 | BACE2 Functions as an Alternative α-Secretase in Cells | Journal of Biological Chemistry | 2001 | 152 |
| 50 | Computer-Aided Design (CAD) of Mn(II) Complexes: Superoxide Dismutase Mimetics with Catalytic Activity Exceeding the Native Enzyme | Inorganic Chemistry | 2001 | 151 |
