| # | Title | Journal | Year | Citations |
|---|
| 1 | GSVA: gene set variation analysis for microarray and RNA-Seq data | BMC Bioinformatics | 2013 | 7,876 |
| 2 | The Immune Landscape of Cancer | Immunity | 2018 | 3,706 |
| 3 | The consensus molecular subtypes of colorectal cancer | Nature Medicine | 2015 | 3,596 |
| 4 | Biological, clinical and population relevance of 95 loci for blood lipids | Nature | 2010 | 3,249 |
| 5 | Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates | Molecular Cell | 2013 | 2,734 |
| 6 | An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics | Cell | 2018 | 2,277 |
| 7 | Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease | Cell | 2013 | 1,505 |
| 8 | Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation | Cell | 2018 | 1,417 |
| 9 | From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus | Nature | 2010 | 1,018 |
| 10 | The efficacy of smartphone‐based mental health interventions for depressive symptoms: a meta‐analysis of randomized controlled trials | World Psychiatry | 2017 | 755 |
| 11 | Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer | Nature Reviews Cancer | 2017 | 686 |
| 12 | Predictive, personalized, preventive, participatory (P4) cancer medicine | Nature Reviews Clinical Oncology | 2011 | 628 |
| 13 | Comprehensive functional genomic resource and integrative model for the human brain | Science | 2018 | 618 |
| 14 | Large-scale evaluation of ANTs and FreeSurfer cortical thickness measurements | NeuroImage | 2014 | 560 |
| 15 | Mindboggling morphometry of human brains | PLoS Computational Biology | 2017 | 448 |
| 16 | The mPower study, Parkinson disease mobile data collected using ResearchKit | Scientific Data | 2016 | 439 |
| 17 | Derivation of naïve human embryonic stem cells | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 415 |
| 18 | An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome | Nature Neuroscience | 2017 | 377 |
| 19 | The PsychENCODE project | Nature Neuroscience | 2015 | 371 |
| 20 | Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases | Scientific Data | 2016 | 361 |
| 21 | A multi-omic atlas of the human frontal cortex for aging and Alzheimer’s disease research | Scientific Data | 2018 | 357 |
| 22 | The National COVID Cohort Collaborative (N3C): Rationale, design, infrastructure, and deployment | Journal of the American Medical Informatics Association: JAMIA | 2021 | 342 |
| 23 | The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease | Scientific Data | 2018 | 320 |
| 24 | Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile | Nature Genetics | 2011 | 289 |
| 25 | Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection | Nature Methods | 2015 | 282 |
| 26 | Molecular Markers Identify Subtypes of Stage III Colon Cancer Associated With Patient Outcomes | Gastroenterology | 2015 | 273 |
| 27 | Analysis of 589,306 genomes identifies individuals resilient to severe Mendelian childhood diseases | Nature Biotechnology | 2016 | 273 |
| 28 | A Pan-cancer Landscape of Interactions between Solid Tumors and Infiltrating Immune Cell Populations | Clinical Cancer Research | 2018 | 267 |
| 29 | Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma | PLoS Genetics | 2012 | 261 |
| 30 | Assessing the clinical utility of cancer genomic and proteomic data across tumor types | Nature Biotechnology | 2014 | 257 |
| 31 | Leveraging models of cell regulation and GWAS data in integrative network-based association studies | Nature Genetics | 2012 | 252 |
| 32 | Evidence for type II cells as cells of origin of K-Ras–induced distal lung adenocarcinoma | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 242 |
| 33 | Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes | Science Translational Medicine | 2017 | 240 |
| 34 | Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen | Nature Communications | 2019 | 240 |
| 35 | Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci | American Journal of Human Genetics | 2012 | 239 |
| 36 | Indicators of retention in remote digital health studies: a cross-study evaluation of 100,000 participants | Npj Digital Medicine | 2020 | 238 |
| 37 | PARP inhibition enhances tumor cell–intrinsic immunity in ERCC1-deficient non–small cell lung cancer | Journal of Clinical Investigation | 2019 | 222 |
| 38 | Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters | Critical Care Medicine | 2018 | 219 |
| 39 | Inferring causal molecular networks: empirical assessment through a community-based effort | Nature Methods | 2016 | 209 |
| 40 | Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models | Cell Reports | 2020 | 199 |
| 41 | A statin-dependent QTL for GATM expression is associated with statin-induced myopathy | Nature | 2013 | 197 |
| 42 | A machine learning approach to integrate big data for precision medicine in acute myeloid leukemia | Nature Communications | 2018 | 194 |
| 43 | Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases | Molecular Systems Biology | 2014 | 182 |
| 44 | Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative | JAMA Network Open | 2021 | 179 |
| 45 | A community approach to mortality prediction in sepsis via gene expression analysis | Nature Communications | 2018 | 178 |
| 46 | Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies | Clinical Cancer Research | 2018 | 177 |
| 47 | Stitching together Multiple Data Dimensions Reveals Interacting Metabolomic and Transcriptomic Networks That Modulate Cell Regulation | PLoS Biology | 2012 | 173 |
| 48 | BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression | Clinical Cancer Research | 2017 | 167 |
| 49 | Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes | Cell Metabolism | 2012 | 166 |
| 50 | Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer’s disease pathogenesis | Nature Genetics | 2021 | 158 |
