| # | Title | Journal | Year | Citations |
|---|
| 1 | Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila | Science | 1995 | 1,516 |
| 2 | GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death | EMBO Journal | 2016 | 842 |
| 3 | Mammalian Epoxide Hydrases: Inducible Enzymes Catalysing the Inactivation of Carcinogenic and Cytotoxic Metabolites Derived from Aromatic and Olefinic Compounds | Xenobiotica | 1973 | 818 |
| 4 | Definitions and guidelines for research on antibiotic persistence | Nature Reviews Microbiology | 2019 | 748 |
| 5 | Cyclic di-GMP: second messenger extraordinaire | Nature Reviews Microbiology | 2017 | 706 |
| 6 | Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1 | Nature Medicine | 2003 | 699 |
| 7 | Nuclear Lamins: Their Structure, Assembly, and Interactions | Journal of Structural Biology | 1998 | 653 |
| 8 | Mechanisms of Cyclic-di-GMP Signaling in Bacteria | Annual Review of Genetics | 2006 | 571 |
| 9 | Nutrient sensing and TOR signaling in yeast and mammals | EMBO Journal | 2017 | 570 |
| 10 | Pharmacogenetics and adverse drug reactions | Lancet, The | 2000 | 556 |
| 11 | Transmembrane Signaling across the Ligand-Gated FhuA Receptor | Cell | 1998 | 527 |
| 12 | MOLECULAR MECHANISMS OF GENETIC POLYMORPHISMS OF DRUG METABOLISM | Annual Review of Pharmacology and Toxicology | 1997 | 499 |
| 13 | Induction of Drug Metabolism: The Role of Nuclear Receptors | Pharmacological Reviews | 2003 | 430 |
| 14 | Dynamic Elastic Modulus of Porcine Articular Cartilage Determined at Two Different Levels of Tissue Organization by Indentation-Type Atomic Force Microscopy | Biophysical Journal | 2004 | 424 |
| 15 | Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases | Nature | 2014 | 416 |
| 16 | The Transcriptional Coactivator PGC-1 Regulates the Expression and Activity of the Orphan Nuclear Receptor Estrogen-Related Receptor α (ERRα) | Journal of Biological Chemistry | 2003 | 409 |
| 17 | Early detection of aging cartilage and osteoarthritis in mice and patient samples using atomic force microscopy | Nature Nanotechnology | 2009 | 391 |
| 18 | Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts | Bone | 2002 | 390 |
| 19 | Structure, evolution and action of vitamin B6-dependent enzymes | Current Opinion in Structural Biology | 1998 | 386 |
| 20 | Ligand binding induces a large conformational change in O-acetylserine sulfhydrylase from Salmonella typhimurium | Journal of Molecular Biology | 1999 | 364 |
| 21 | Imaging and manipulation of biological structures with the AFM | Micron | 2002 | 364 |
| 22 | Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development | Neural Development | 2008 | 340 |
| 23 | Watching amyloid fibrils grow by time-lapse atomic force microscopy 1 1Edited by W. Baumeister | Journal of Molecular Biology | 1999 | 331 |
| 24 | The absence of Emp24p, a component of ER-derived COPII-coated vesicles, causes a defect in transport of selected proteins to the Golgi. | EMBO Journal | 1995 | 329 |
| 25 | Specific Retrieval of the Exocytic SNARE Snc1p from Early Yeast Endosomes | Molecular Biology of the Cell | 2000 | 326 |
| 26 | end5, end6, and end7: mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae. | Molecular Biology of the Cell | 1995 | 314 |
| 27 | Alternative cleavage and polyadenylation in health and disease | Nature Reviews Genetics | 2019 | 305 |
| 28 | Solution NMR of proteins within polyacrylamide gels: diffusional properties and residual alignment by mechanical stress or embedding of oriented purple membranes | Journal of Biomolecular NMR | 2000 | 304 |
| 29 | Adsorption of Biological Molecules to a Solid Support for Scanning Probe Microscopy | Journal of Structural Biology | 1997 | 293 |
| 30 | Thalamic nuclei convey diverse contextual information to layer 1 of visual cortex | Nature Neuroscience | 2016 | 292 |
| 31 | A Tissue-Specific Coactivator of Steroid Receptors, Identified in a Functional Genetic Screen | Molecular and Cellular Biology | 2000 | 286 |
| 32 | Polymorphic Fibrillar Assembly of Human Amylin | Journal of Structural Biology | 1997 | 284 |
| 33 | The Leptin Receptor Activates Janus Kinase 2 and Signals for Proliferation in a Factor-Dependent Cell Line | Molecular Endocrinology | 1997 | 282 |
| 34 | Shared Synaptic Pathophysiology in Syndromic and Nonsyndromic Rodent Models of Autism | Science | 2012 | 278 |
| 35 | Functional selection and analysis of yeast centromeric DNA | Cell | 1985 | 270 |
| 36 | PGC-1, a versatile coactivator | Trends in Endocrinology and Metabolism | 2001 | 269 |
| 37 | The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast. | Molecular Biology of the Cell | 1994 | 265 |
| 38 | Lag1p and Lac1p Are Essential for the Acyl-CoA–dependent Ceramide Synthase Reaction inSaccharomyces cerevisae | Molecular Biology of the Cell | 2001 | 263 |
| 39 | Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: identification of six new END genes. | Journal of Cell Biology | 1994 | 260 |
| 40 | Structural basis of small-molecule inhibition of human multidrug transporter ABCG2 | Nature Structural and Molecular Biology | 2018 | 258 |
| 41 | The Protein Model Portal—a comprehensive resource for protein structure and model information | Database: the Journal of Biological Databases and Curation | 2013 | 254 |
| 42 | The master control gene for morphogenesis and evolution of the eye | Genes To Cells | 1996 | 250 |
| 43 | Nuclear mRNA Export Requires Complex Formation between Mex67p and Mtr2p at the Nuclear Pores | Molecular and Cellular Biology | 1998 | 248 |
| 44 | Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 236 |
| 45 | The Emp24 Complex Recruits a Specific Cargo Molecule into Endoplasmic Reticulum–Derived Vesicles | Journal of Cell Biology | 2000 | 234 |
| 46 | Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin | Cell | 2016 | 233 |
| 47 | The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors. | Genes and Development | 1992 | 232 |
| 48 | Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae | EMBO Journal | 2000 | 231 |
| 49 | Protein Sorting upon Exit from the Endoplasmic Reticulum | Cell | 2001 | 227 |
| 50 | Coupling site-directed mutagenesis with high-level expression: large scale production of mutant porins fromE. coli | FEMS Microbiology Letters | 1998 | 221 |
