| # | Title | Journal | Year | Citations |
|---|
| 1 | The complete genome sequence of the Gram-positive bacterium Bacillus subtilis | Nature | 1997 | 3,519 |
| 2 | The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells | Cell | 2003 | 2,892 |
| 3 | Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase) | Science | 1996 | 2,693 |
| 4 | Global landscape of protein complexes in the yeast Saccharomyces cerevisiae | Nature | 2006 | 2,681 |
| 5 | Toll-Like Receptor Signaling Pathways | Frontiers in Immunology | 2014 | 2,349 |
| 6 | Whole genome sequencing of meticillin-resistant Staphylococcus aureus | Lancet, The | 2001 | 1,835 |
| 7 | MassBank: a public repository for sharing mass spectral data for life sciences | Journal of Mass Spectrometry | 2010 | 1,831 |
| 8 | Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase) | Journal of Biological Chemistry | 1996 | 1,767 |
| 9 | Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin | Science | 2005 | 1,694 |
| 10 | Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance | Nature Immunology | 2002 | 1,566 |
| 11 | Extensive impact of non-antibiotic drugs on human gut bacteria | Nature | 2018 | 1,339 |
| 12 | Essential Bacillus subtilis genes | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 1,261 |
| 13 | Complete set of ORF clones of Escherichia coli ASKA library (A Complete Set of E. coli K-12 ORF Archive): Unique Resources for Biological Research | DNA Research | 2006 | 1,213 |
| 14 | Genome sequencing and analysis of Aspergillus oryzae | Nature | 2005 | 1,128 |
| 15 | TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction | Nature Immunology | 2003 | 1,107 |
| 16 | Hd3a Protein Is a Mobile Flowering Signal in Rice | Science | 2007 | 1,067 |
| 17 | Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D | Nature | 2004 | 1,016 |
| 18 | Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase | Science | 1997 | 999 |
| 19 | Insights into Land Plant Evolution Garnered from the Marchantia polymorpha Genome | Cell | 2017 | 973 |
| 20 | Intracellular temperature mapping with a fluorescent polymeric thermometer and fluorescence lifetime imaging microscopy | Nature Communications | 2012 | 952 |
| 21 | Conserved factors regulate signalling in Arabidopsis thaliana shoot and root stem cell organizers | Nature | 2007 | 943 |
| 22 | Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells | Annual Review of Biochemistry | 1999 | 941 |
| 23 | Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. | EMBO Journal | 1996 | 932 |
| 24 | Preparation and assessment of revised simulated body fluids | Journal of Biomedical Materials Research Part B | 2003 | 897 |
| 25 | PGR5 Is Involved in Cyclic Electron Flow around Photosystem I and Is Essential for Photoprotection in Arabidopsis | Cell | 2002 | 873 |
| 26 | ARF7 and ARF19 Regulate Lateral Root Formation via Direct Activation of LBD/ASL Genes in Arabidopsis | Plant Cell | 2007 | 805 |
| 27 | A Genetic Framework for the Control of Cell Division and Differentiation in the Root Meristem | Science | 2008 | 802 |
| 28 | Cyclic electron flow around photosystem I is essential for photosynthesis | Nature | 2004 | 793 |
| 29 | Over-expression of a single Ca2+-dependent protein kinase confers both cold and salt/drought tolerance on rice plants | Plant Journal | 2000 | 791 |
| 30 | Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death | Journal of Cell Biology | 2004 | 775 |
| 31 | Comparative Metagenomics Revealed Commonly Enriched Gene Sets in Human Gut Microbiomes | DNA Research | 2007 | 760 |
| 32 | Prediction of immediate and future rewards differentially recruits cortico-basal ganglia loops | Nature Neuroscience | 2004 | 757 |
| 33 | Targeted Ablation of Osteocytes Induces Osteoporosis with Defective Mechanotransduction | Cell Metabolism | 2007 | 735 |
| 34 | Activation of Caspase-12, an Endoplastic Reticulum (ER) Resident Caspase, through Tumor Necrosis Factor Receptor-associated Factor 2-dependent Mechanism in Response to the ER Stress | Journal of Biological Chemistry | 2001 | 727 |
| 35 | Voice Conversion Based on Maximum-Likelihood Estimation of Spectral Parameter Trajectory | IEEE Transactions on Audio Speech and Language Processing | 2007 | 711 |
| 36 | The Genome of the Western Clawed Frog Xenopus tropicalis | Science | 2010 | 708 |
| 37 | Rho–Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells | Trends in Pharmacological Sciences | 2001 | 693 |
| 38 | Genome Structure of the Legume, Lotus japonicus | DNA Research | 2008 | 691 |
| 39 | CRMP-2 binds to tubulin heterodimers to promote microtubule assembly | Nature Cell Biology | 2002 | 687 |
| 40 | Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration | Nature | 2010 | 686 |
| 41 | Adaptation of photoperiodic control pathways produces short-day flowering in rice | Nature | 2003 | 680 |
| 42 | The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity | Cell | 1996 | 677 |
| 43 | Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 656 |
| 44 | Lateral root formation is blocked by a gain-of-function mutation in the SOLITARY-ROOT/IAA14 gene of Arabidopsis | Plant Journal | 2002 | 654 |
| 45 | SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity | Nature Genetics | 2001 | 649 |
| 46 | A Bayesian missing value estimation method for gene expression profile data | Bioinformatics | 2003 | 607 |
| 47 | SELF-INCOMPATIBILITY IN PLANTS | Annual Review of Plant Biology | 2005 | 602 |
| 48 | Gibberellin-induced DELLA recognition by the gibberellin receptor GID1 | Nature | 2008 | 594 |
| 49 | Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1 | Nature | 1999 | 593 |
| 50 | Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis | Nature Neuroscience | 2009 | 584 |
