| # | Title | Journal | Year | Citations |
|---|
| 1 | A Revised Medium for Rapid Growth and Bio Assays with Tobacco Tissue Cultures | Physiologia Plantarum | 1962 | 56,749 |
| 2 | Fiji: an open-source platform for biological-image analysis | Nature Methods | 2012 | 47,818 |
| 3 | NIH Image to ImageJ: 25 years of image analysis | Nature Methods | 2012 | 46,756 |
| 4 | MrBayes 3.2: Efficient Bayesian Phylogenetic Inference and Model Choice Across a Large Model Space | Systematic Biology | 2012 | 20,458 |
| 5 | RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome | BMC Bioinformatics | 2011 | 16,042 |
| 6 | Embryonic Stem Cell Lines Derived from Human Blastocysts | BMC Bioinformatics | 1998 | 13,539 |
| 7 | Bioconductor: open software development for computational biology and bioinformatics | Genome Biology | 2004 | 10,796 |
| 8 | A Proportional Hazards Model for the Subdistribution of a Competing Risk | Journal of the American Statistical Association | 1999 | 10,534 |
| 9 | Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells | Science | 2007 | 9,459 |
| 10 | Global Consequences of Land Use | Science | 2005 | 9,451 |
| 11 | A Paradigm for Developing Better Measures of Marketing Constructs | Journal of Marketing Research | 1979 | 9,201 |
| 12 | The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults | New England Journal of Medicine | 1993 | 9,133 |
| 13 | Managing Legitimacy: Strategic and Institutional Approaches | Academy of Management Review | 1995 | 9,080 |
| 14 | Natural population analysis | Journal of Chemical Physics | 1985 | 8,757 |
| 15 | A simplification of the protein assay method of Lowry et al. which is more generally applicable | Analytical Biochemistry | 1977 | 8,587 |
| 16 | On the Einstein Podolsky Rosen paradox | Physics Physique Физика | 1964 | 8,020 |
| 17 | Spin Diffusion Measurements: Spin Echoes in the Presence of a Time‐Dependent Field Gradient | Journal of Chemical Physics | 1965 | 7,292 |
| 18 | The Complete Genome Sequence of Escherichia coli K-12 | Science | 1997 | 7,145 |
| 19 | Planetary boundaries: Guiding human development on a changing planet | Science | 2015 | 7,124 |
| 20 | De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis | Nature Protocols | 2013 | 7,054 |
| 21 | Constrained model predictive control: Stability and optimality | Automatica | 2000 | 6,750 |
| 22 | Selenium: Biochemical Role as a Component of Glutathione Peroxidase | Science | 1973 | 6,415 |
| 23 | An Efficient Method of Estimating Seemingly Unrelated Regressions and Tests for Aggregation Bias | Journal of the American Statistical Association | 1962 | 5,928 |
| 24 | Solutions for a cultivated planet | Nature | 2011 | 5,821 |
| 25 | Absorptive Capacity: A Review, Reconceptualization, and Extension | Academy of Management Review | 2002 | 5,702 |
| 26 | A Real-Time QRS Detection Algorithm | IEEE Transactions on Biomedical Engineering | 1985 | 5,695 |
| 27 | Catastrophic shifts in ecosystems | Nature | 2001 | 5,656 |
| 28 | Integrative analysis of 111 reference human epigenomes | Nature | 2015 | 5,653 |
| 29 | Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2006 | 5,525 |
| 30 | Comparison of Four Chemotherapy Regimens for Advanced Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2002 | 4,873 |
| 31 | Dose translation from animal to human studies revisited | FASEB Journal | 2008 | 4,838 |
| 32 | Model selection and estimation in regression with grouped variables | Journal of the Royal Statistical Society Series B: Statistical Methodology | 2006 | 4,736 |
| 33 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 34 | Strength and Breaking Mechanism of Multiwalled Carbon Nanotubes Under Tensile Load | Science | 2000 | 4,695 |
| 35 | ImageJ2: ImageJ for the next generation of scientific image data | BMC Bioinformatics | 2017 | 4,464 |
| 36 | NONPOINT POLLUTION OF SURFACE WATERS WITH PHOSPHORUS AND NITROGEN | BMC Bioinformatics | 1998 | 4,255 |
| 37 | Resilience, Adaptability and Transformability in Social-ecological Systems | Ecology and Society | 2004 | 4,244 |
| 38 | Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction | New England Journal of Medicine | 2019 | 4,108 |
| 39 | Mauve: Multiple Alignment of Conserved Genomic Sequence With Rearrangements | Genome Research | 2004 | 4,085 |
| 40 | Toward a Theory of Culturally Relevant Pedagogy | American Educational Research Journal | 1995 | 3,944 |
| 41 | Impure Altruism and Donations to Public Goods: A Theory of Warm-Glow Giving | Economic Journal | 1990 | 3,910 |
| 42 | Allergic Rhinitis and its Impact on Asthma (ARIA) 2008* | Allergy: European Journal of Allergy and Clinical Immunology | 2008 | 3,827 |
| 43 | Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices | Journal of Pharmaceutical Sciences | 1963 | 3,810 |
| 44 | The gem5 simulator | Computer Architecture News | 2011 | 3,750 |
| 45 | Epidemiology of Obstructive Sleep Apnea | American Journal of Respiratory and Critical Care Medicine | 2002 | 3,723 |
| 46 | Direct Gene Transfer into Mouse Muscle in Vivo | Science | 1990 | 3,687 |
| 47 | An Analysis of Transformations | Journal of the Royal Statistical Society Series B: Methodological | 1964 | 3,686 |
| 48 | School readiness and later achievement. | Developmental Psychology | 2007 | 3,669 |
| 49 | progressiveMauve: Multiple Genome Alignment with Gene Gain, Loss and Rearrangement | PLoS ONE | 2010 | 3,652 |
| 50 | A unified mixed-model method for association mapping that accounts for multiple levels of relatedness | Nature Genetics | 2006 | 3,622 |
