| # | Title | Journal | Year | Citations |
|---|
| 1 | GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects | Cell | 2010 | 2,013 |
| 2 | The Vienna classification of gastrointestinal epithelial neoplasia | Gut | 2000 | 1,838 |
| 3 | HRS/EHRA/APHRS Expert Consensus Statement on the Diagnosis and Management of Patients with Inherited Primary Arrhythmia Syndromes | Heart Rhythm | 2013 | 1,587 |
| 4 | Increased expression of interleukin 17 in inflammatory bowel disease | Gut | 2003 | 1,436 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 6 | Mutations of optineurin in amyotrophic lateral sclerosis | Nature | 2010 | 1,097 |
| 7 | The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43 | Nature Communications | 2013 | 1,089 |
| 8 | Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin | Gastroenterology | 2001 | 1,088 |
| 9 | The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019) | Hypertension Research | 2019 | 1,047 |
| 10 | In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses | Nature | 2009 | 1,002 |
| 11 | Human metabolic phenotype diversity and its association with diet and blood pressure | Nature | 2008 | 966 |
| 12 | The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014) | Hypertension Research | 2014 | 962 |
| 13 | Gut microbiota in the pathogenesis of inflammatory bowel disease | Clinical Journal of Gastroenterology | 2018 | 904 |
| 14 | The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis | Experimental Dermatology | 2001 | 897 |
| 15 | Attenuation of Compensation of Endogenous Cardiac Natriuretic Peptide System in Chronic Heart Failure | Circulation | 1997 | 851 |
| 16 | Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus | Nature Genetics | 2008 | 694 |
| 17 | A standard method to calibrate sonochemical efficiency of an individual reaction system | Ultrasonics Sonochemistry | 2003 | 691 |
| 18 | Plasma brain natriuretic peptide as a biochemical marker of high left ventricular end-diastolic pressure in patients with symptomatic left ventricular dysfunction | American Heart Journal | 1998 | 690 |
| 19 | SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations | Nature Genetics | 2008 | 641 |
| 20 | Prevalence of Parkinson’s disease across North America | Npj Parkinson's Disease | 2018 | 611 |
| 21 | Cardiovascular Disease and Risk Factors in Asia | Circulation | 2008 | 604 |
| 22 | Effect of 1-Month Dual Antiplatelet Therapy Followed by Clopidogrel vs 12-Month Dual Antiplatelet Therapy on Cardiovascular and Bleeding Events in Patients Receiving PCI | JAMA - Journal of the American Medical Association | 2019 | 602 |
| 23 | A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn’s disease☆ | Gastroenterology | 2004 | 600 |
| 24 | Curcumin Maintenance Therapy for Ulcerative Colitis: Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial | Clinical Gastroenterology and Hepatology | 2006 | 565 |
| 25 | A cross-population atlas of genetic associations for 220 human phenotypes | Nature Genetics | 2021 | 560 |
| 26 | Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney | Journal of Clinical Investigation | 2010 | 560 |
| 27 | Absence of hemodynamic tolerance to nicorandil in patients with severe congestive heart failure | American Heart Journal | 1994 | 549 |
| 28 | A simple method to estimate populational 24-h urinary sodium and potassium excretion using a casual urine specimen | Journal of Human Hypertension | 2002 | 541 |
| 29 | Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption | Nature Genetics | 2001 | 539 |
| 30 | A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development | Nature Cell Biology | 2005 | 532 |
| 31 | Interleukin-6 Spillover in the Peripheral Circulation Increases With the Severity of Heart Failure, and the High Plasma Level of Interleukin-6 Is an Important Prognostic Predictor in Patients With Congestive Heart Failure | Journal of the American College of Cardiology | 1998 | 488 |
| 32 | Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death | Nature Genetics | 2013 | 467 |
| 33 | Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease | Digestion | 2016 | 458 |
| 34 | Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP2 | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 444 |
| 35 | Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice | Clinical Immunology | 2004 | 439 |
| 36 | Interleukin-22, a Member of the IL-10 Subfamily, Induces Inflammatory Responses in Colonic Subepithelial Myofibroblasts | Gastroenterology | 2005 | 439 |
| 37 | Germline gain-of-function mutations in RAF1 cause Noonan syndrome | Nature Genetics | 2007 | 438 |
| 38 | NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice | Nature Medicine | 2003 | 430 |
| 39 | Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells | Cell Stem Cell | 2015 | 428 |
| 40 | A developmental coordinate of pluripotency among mice, monkeys and humans | Nature | 2016 | 419 |
| 41 | Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes | FASEB Journal | 2000 | 417 |
| 42 | CT-guided needle biopsy of lung lesions: A survey of severe complication based on 9783 biopsies in Japan | European Journal of Radiology | 2006 | 404 |
| 43 | Nutrient intakes of middle-aged men and women in China, Japan, United Kingdom, and United States in the late 1990s: The INTERMAP Study | Journal of Human Hypertension | 2003 | 400 |
| 44 | De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood | Nature Genetics | 2013 | 396 |
| 45 | Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study | Blood | 2009 | 383 |
| 46 | High levels of plasma brain natriuretic peptide and interleukin-6 after optimized treatment for heart failure are independent risk factors for morbidity and mortality in patients with congestive heart failure | Journal of the American College of Cardiology | 2000 | 382 |
| 47 | Brachial-Ankle Pulse Wave Velocity and the Risk Prediction of Cardiovascular Disease | Hypertension | 2017 | 382 |
| 48 | Localization of NADPH-diaphorase-containing neurons in sensory ganglia of the rat | Journal of Comparative Neurology | 1991 | 377 |
| 49 | Kyphotic malalignment after anterior cervical fusion is one of the factors promoting the degenerative process in adjacent intervertebral levels | European Spine Journal | 2001 | 372 |
| 50 | Role of premature leptin surge in obesity resulting from intrauterine undernutrition | Cell Metabolism | 2005 | 370 |
