| # | Title | Journal | Year | Citations |
|---|
| 1 | Intensive Insulin Therapy in Critically Ill Patients | New England Journal of Medicine | 2001 | 14,320 |
| 2 | The Pascal Visual Object Classes (VOC) Challenge | International Journal of Computer Vision | 2010 | 12,097 |
| 3 | Least Squares Support Vector Machine Classifiers | Neural Processing Letters | 1999 | 7,709 |
| 4 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial | Lancet, The | 2010 | 5,899 |
| 5 | 2007 Guidelines for the Management of Arterial Hypertension | Journal of Hypertension | 2007 | 4,778 |
| 6 | Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer | New England Journal of Medicine | 2004 | 4,721 |
| 7 | Intensive Insulin Therapy in the Medical ICU | New England Journal of Medicine | 2006 | 4,713 |
| 8 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 9 | Histological grading and staging of chronic hepatitis | Journal of Hepatology | 1995 | 4,685 |
| 10 | 2013 ESH/ESC Guidelines for the management of arterial hypertension | Journal of Hypertension | 2013 | 4,251 |
| 11 | The Pascal Visual Object Classes Challenge: A Retrospective | International Journal of Computer Vision | 2015 | 4,116 |
| 12 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,038 |
| 13 | IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040 | Diabetes Research and Clinical Practice | 2017 | 4,032 |
| 14 | Functional profiling of the Saccharomyces cerevisiae genome | Nature | 2002 | 3,938 |
| 15 | Photodynamic therapy of cancer: An update | Ca-A Cancer Journal for Clinicians | 2011 | 3,902 |
| 16 | Multimodality image registration by maximization of mutual information | IEEE Transactions on Medical Imaging | 1997 | 3,793 |
| 17 | Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele | Nature | 1996 | 3,776 |
| 18 | Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis | Science | 1999 | 3,761 |
| 19 | Minimum information about a microarray experiment (MIAME)—toward standards for microarray data | Nature Genetics | 2001 | 3,750 |
| 20 | Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer | New England Journal of Medicine | 2009 | 3,543 |
| 21 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update | Annals of the Rheumatic Diseases | 2017 | 3,366 |
| 22 | Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia | New England Journal of Medicine | 2003 | 3,227 |
| 23 | Five-Year Follow-up of Patients Receiving Imatinib for Chronic Myeloid Leukemia | New England Journal of Medicine | 2006 | 3,212 |
| 24 | A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease | New England Journal of Medicine | 1997 | 3,152 |
| 25 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 26 | Angiogenesis in life, disease and medicine | Nature | 2005 | 3,097 |
| 27 | SCENIC: single-cell regulatory network inference and clustering | Nature Methods | 2017 | 3,086 |
| 28 | Genomic Classification and Prognosis in Acute Myeloid Leukemia | New England Journal of Medicine | 2016 | 3,067 |
| 29 | Lanthanide-Based Luminescent Hybrid Materials | Chemical Reviews | 2009 | 2,989 |
| 30 | Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension | Lancet, The | 1997 | 2,841 |
| 31 | Treatment of Hypertension in Patients 80 Years of Age or Older | New England Journal of Medicine | 2008 | 2,714 |
| 32 | Infliximab for the Treatment of Fistulas in Patients with Crohn's Disease | New England Journal of Medicine | 1999 | 2,665 |
| 33 | Pre-eclampsia | Lancet, The | 2010 | 2,648 |
| 34 | Structure and Functions of the Bacterial Microbiota of Plants | Annual Review of Plant Biology | 2013 | 2,589 |
| 35 | Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporosis | New England Journal of Medicine | 2007 | 2,536 |
| 36 | A Comparison of Affine Region Detectors | International Journal of Computer Vision | 2005 | 2,469 |
| 37 | Classification of chronic hepatitis: Diagnosis, grading and staging | Hepatology | 1994 | 2,456 |
| 38 | Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary | American Journal of Respiratory and Critical Care Medicine | 2017 | 2,393 |
| 39 | A blueprint for blue carbon: toward an improved understanding of the role of vegetated coastal habitats in sequestering CO2 | Frontiers in Ecology and the Environment | 2011 | 2,354 |
| 40 | How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology | European Heart Journal | 2007 | 2,302 |
| 41 | Wetting and spreading | Reviews of Modern Physics | 2009 | 2,278 |
| 42 | Principles and potential of the anaerobic digestion of waste-activated sludge | Progress in Energy and Combustion Science | 2008 | 2,275 |
| 43 | Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib | New England Journal of Medicine | 2015 | 2,240 |
| 44 | A review of classic Fenton’s peroxidation as an advanced oxidation technique | Journal of Hazardous Materials | 2003 | 2,239 |
| 45 | The Impact of Charging Plug-In Hybrid Electric Vehicles on a Residential Distribution Grid | IEEE Transactions on Power Systems | 2010 | 2,213 |
| 46 | Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis | Gastroenterology | 2013 | 2,211 |
| 47 | Phase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors | New England Journal of Medicine | 2017 | 2,206 |
| 48 | A study of the microstructural evolution during selective laser melting of Ti–6Al–4V | Acta Materialia | 2010 | 2,189 |
| 49 | Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes | New England Journal of Medicine | 2015 | 2,188 |
| 50 | Natural fibres: can they replace glass in fibre reinforced plastics? | Composites Science and Technology | 2003 | 2,165 |
