| # | Title | Journal | Year | Citations |
|---|
| 1 | Hallmarks of Cancer: The Next Generation | Cell | 2011 | 52,242 |
| 2 | MicroRNAs | Cell | 2004 | 32,446 |
| 3 | The Hallmarks of Cancer | Cell | 2000 | 24,832 |
| 4 | Initial sequencing and analysis of the human genome | Nature | 2001 | 21,074 |
| 5 | Primer3 on the WWW for General Users and for Biologist Programmers | Nature | 2000 | 9,865 |
| 6 | The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells | Cell | 2008 | 7,695 |
| 7 | mTOR Signaling in Growth Control and Disease | Cell | 2012 | 7,066 |
| 8 | MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations | Genomics | 1987 | 6,607 |
| 9 | Predicting effective microRNA target sites in mammalian mRNAs | ELife | 2015 | 5,779 |
| 10 | Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex | Science | 2005 | 5,761 |
| 11 | Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals | Nature Genetics | 2003 | 5,434 |
| 12 | Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results | Nature Genetics | 1995 | 5,020 |
| 13 | A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells | Cell | 2006 | 4,773 |
| 14 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 15 | Prediction of Mammalian MicroRNA Targets | Cell | 2003 | 4,682 |
| 16 | Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. | Genetics | 1989 | 4,642 |
| 17 | In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector | Science | 1996 | 4,589 |
| 18 | The retinoblastoma protein and cell cycle control | Cell | 1995 | 4,548 |
| 19 | Alternative isoform regulation in human tissue transcriptomes | Nature | 2008 | 4,508 |
| 20 | Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs | Nature | 2005 | 4,435 |
| 21 | CellProfiler: image analysis software for identifying and quantifying cell phenotypes | Genome Biology | 2006 | 4,287 |
| 22 | Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells | Cell | 2005 | 4,000 |
| 23 | A Perspective on Cancer Cell Metastasis | Science | 2011 | 3,985 |
| 24 | The Genome of Black Cottonwood, Populus trichocarpa (Torr. & Gray) | Science | 2006 | 3,945 |
| 25 | Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals | Nature | 2009 | 3,801 |
| 26 | Genome-wide maps of chromatin state in pluripotent and lineage-committed cells | Nature | 2007 | 3,733 |
| 27 | Targeted mutation of the DNA methyltransferase gene results in embryonic lethality | Cell | 1992 | 3,677 |
| 28 | Mammalian microRNAs predominantly act to decrease target mRNA levels | Nature | 2010 | 3,513 |
| 29 | mTOR: from growth signal integration to cancer, diabetes and ageing | Nature Reviews Molecular Cell Biology | 2011 | 3,464 |
| 30 | Histone H3K27ac separates active from poised enhancers and predicts developmental state | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 3,446 |
| 31 | Understanding the tumor immune microenvironment (TIME) for effective therapy | Nature Medicine | 2018 | 3,421 |
| 32 | Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis | Cell | 2004 | 3,405 |
| 33 | The GTPase superfamily: conserved structure and molecular mechanism | Nature | 1991 | 3,349 |
| 34 | Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion | Cell | 2005 | 3,273 |
| 35 | The impact of microRNAs on protein output | Nature | 2008 | 3,270 |
| 36 | Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes | Cell | 2013 | 3,202 |
| 37 | Genetic dissection of complex traits | Science | 1994 | 3,158 |
| 38 | Tumor Metastasis: Molecular Insights and Evolving Paradigms | Cell | 2011 | 3,143 |
| 39 | One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering | Cell | 2013 | 3,133 |
| 40 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 41 | An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans | Science | 2001 | 3,041 |
| 42 | MicroRNAs Modulate Hematopoietic Lineage Differentiation | Science | 2004 | 3,025 |
| 43 | Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits | Nature Reviews Cancer | 2009 | 2,951 |
| 44 | Super-Enhancers in the Control of Cell Identity and Disease | Cell | 2013 | 2,916 |
| 45 | Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes | Nature | 1983 | 2,901 |
| 46 | A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma | Nature | 1986 | 2,853 |
| 47 | Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. | Journal of Experimental Medicine | 1996 | 2,739 |
| 48 | Interpreting patterns of gene expression with self-organizing maps: Methods and application to hematopoietic differentiation | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 2,731 |
| 49 | Transcriptional Regulatory Networks in Saccharomyces cerevisiae | Science | 2002 | 2,706 |
| 50 | A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes | Journal of Biological Chemistry | 1995 | 2,702 |
