| # | Title | Journal | Year | Citations |
|---|
| 1 | Protein Misfolding, Functional Amyloid, and Human Disease | Annual Review of Biochemistry | 2006 | 5,737 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 4,561 |
| 4 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration | Lancet Neurology, The | 2013 | 3,919 |
| 5 | Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease | Nature | 1995 | 3,894 |
| 6 | Magnetic bistability in a metal-ion cluster | Nature | 1993 | 3,860 |
| 7 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Nature Genetics | 2013 | 3,741 |
| 8 | The size and burden of mental disorders and other disorders of the brain in Europe 2010 | European Neuropsychopharmacology | 2011 | 2,930 |
| 9 | Carbonic anhydrases: novel therapeutic applications for inhibitors and activators | Nature Reviews Drug Discovery | 2008 | 2,702 |
| 10 | Quantum Tunneling of Magnetization and Related Phenomena in Molecular Materials | Angewandte Chemie - International Edition | 2003 | 2,637 |
| 11 | Microalgae for oil: Strain selection, induction of lipid synthesis and outdoor mass cultivation in a low‐cost photobioreactor | Biotechnology and Bioengineering | 2009 | 2,628 |
| 12 | Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges | Lancet Neurology, The | 2010 | 2,586 |
| 13 | 2013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative | Arthritis and Rheumatism | 2013 | 2,359 |
| 14 | Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases | Nature | 2002 | 2,322 |
| 15 | Assessment of cardiac output from systemic arterial pressure in humans | Critical Care Medicine | 2002 | 2,062 |
| 16 | Effects of fire on properties of forest soils: a review | Oecologia | 2005 | 2,058 |
| 17 | Concept Misformation in Comparative Politics | American Political Science Review | 1970 | 1,996 |
| 18 | Natural products in drug discovery: advances and opportunities | Nature Reviews Drug Discovery | 2021 | 1,990 |
| 19 | Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene | Nature | 1995 | 1,977 |
| 20 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 21 | Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade | Annual Review of Biochemistry | 2017 | 1,929 |
| 22 | Response to cadmium in higher plants | Environmental and Experimental Botany | 1999 | 1,893 |
| 23 | An anomalous positron abundance in cosmic rays with energies 1.5–100 GeV | Nature | 2009 | 1,794 |
| 24 | CONSENSUS: Guidelines for Diagnosis and Therapy of MEN Type 1 and Type 2 | Journal of Clinical Endocrinology and Metabolism | 2001 | 1,782 |
| 25 | The Myofibroblast | American Journal of Pathology | 2007 | 1,782 |
| 26 | Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans | Mechanisms of Ageing and Development | 2007 | 1,759 |
| 27 | Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease | Nature Genetics | 2011 | 1,708 |
| 28 | 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative | Annals of the Rheumatic Diseases | 2013 | 1,705 |
| 29 | Phenotypic and functional features of human Th17 cells | Journal of Experimental Medicine | 2007 | 1,689 |
| 30 | Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22 | Immunity | 2013 | 1,663 |
| 31 | CHIANTI - an atomic database for emission lines | Astronomy and Astrophysics | 1997 | 1,640 |
| 32 | Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. | Journal of Experimental Medicine | 1993 | 1,615 |
| 33 | Magnetism of Lanthanides in Molecular Materials with Transition-Metal Ions and Organic Radicals | Chemical Reviews | 2002 | 1,512 |
| 34 | Microbial diversity and soil functions | European Journal of Soil Science | 2003 | 1,496 |
| 35 | Randomized Trial of the Effects of Risedronate on Vertebral Fractures in Women with Established Postmenopausal Osteoporosis | Osteoporosis International | 2000 | 1,461 |
| 36 | The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1 | Epilepsia | 2011 | 1,454 |
| 37 | Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution | Journal of Molecular Medicine | 2003 | 1,444 |
| 38 | Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex | Science | 2002 | 1,441 |
| 39 | Flavonoids as antioxidants in plants: Location and functional significance | Plant Science | 2012 | 1,408 |
| 40 | TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system | Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin | 2006 | 1,403 |
| 41 | Anderson localization of a non-interacting Bose–Einstein condensate | Nature | 2008 | 1,393 |
| 42 | Quantum Phase Interference and Parity Effects in Magnetic Molecular Clusters | Science | 1999 | 1,386 |
| 43 | Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis | American Journal of Clinical Nutrition | 2010 | 1,318 |
| 44 | Polyoxometalates: Very Large ClustersNanoscale Magnets | Chemical Reviews | 1998 | 1,304 |
| 45 | Lymphokine Production by Human T Cells in Disease States | Annual Review of Immunology | 1994 | 1,295 |
| 46 | A general algorithm for calculating jet cross sections in NLO QCD | Nuclear Physics B | 1997 | 1,281 |
| 47 | Adherence to Mediterranean diet and health status: meta-analysis | BMJ: British Medical Journal | 2008 | 1,259 |
| 48 | Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC) | Blood | 2007 | 1,243 |
| 49 | Role for Interferon-γ in the Immunomodulatory Activity of Human Bone Marrow Mesenchymal Stem Cells | Stem Cells | 2006 | 1,226 |
| 50 | The Einstein Telescope: a third-generation gravitational wave observatory | Classical and Quantum Gravity | 2010 | 1,211 |
