| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Protein Misfolding, Functional Amyloid, and Human Disease | Annual Review of Biochemistry | 2006 | 5,832 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,789 |
| 3 | Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 4,709 |
| 4 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration | Lancet Neurology, The | 2013 | 4,173 |
| 5 | Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease | Nature | 1995 | 3,923 |
| 6 | Magnetic bistability in a metal-ion cluster | Nature | 1993 | 3,922 |
| 7 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Nature Genetics | 2013 | 3,872 |
| 8 | WHO-EORTC classification for cutaneous lymphomas | Blood | 2005 | 3,564 |
| 9 | Carbonic anhydrases: novel therapeutic applications for inhibitors and activators | Nature Reviews Drug Discovery | 2008 | 2,772 |
| 10 | Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges | Lancet Neurology, The | 2010 | 2,701 |
| 11 | Microalgae for oil: Strain selection, induction of lipid synthesis and outdoor mass cultivation in a low‐cost photobioreactor | Biotechnology and Bioengineering | 2009 | 2,664 |
| 12 | Quantum Tunneling of Magnetization and Related Phenomena in Molecular Materials | Angewandte Chemie - International Edition | 2003 | 2,660 |
| 13 | 2013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative | Arthritis and Rheumatism | 2013 | 2,467 |
| 14 | Natural products in drug discovery: advances and opportunities | Nature Reviews Drug Discovery | 2021 | 2,404 |
| 15 | Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases | Nature | 2002 | 2,345 |
| 16 | Effects of fire on properties of forest soils: a review | Oecologia | 2005 | 2,156 |
| 17 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 2,145 |
| 18 | Concept Misformation in Comparative Politics | American Political Science Review | 1970 | 2,073 |
| 19 | Assessment of cardiac output from systemic arterial pressure in humans | Critical Care Medicine | 2002 | 2,064 |
| 20 | Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene | Nature | 1995 | 1,999 |
| 21 | 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative | Annals of the Rheumatic Diseases | 2013 | 1,847 |
| 22 | An anomalous positron abundance in cosmic rays with energies 1.5–100 GeV | Nature | 2009 | 1,812 |
| 23 | CONSENSUS: Guidelines for Diagnosis and Therapy of MEN Type 1 and Type 2 | Journal of Clinical Endocrinology and Metabolism | 2001 | 1,803 |
| 24 | Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22 | Immunity | 2013 | 1,759 |
| 25 | Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease | Nature Genetics | 2011 | 1,756 |
| 26 | Phenotypic and functional features of human Th17 cells | Journal of Experimental Medicine | 2007 | 1,707 |
| 27 | CHIANTI - an atomic database for emission lines | Astronomy and Astrophysics | 1997 | 1,680 |
| 28 | Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. | Journal of Experimental Medicine | 1993 | 1,627 |
| 29 | GW170817: Measurements of Neutron Star Radii and Equation of State | Physical Review Letters | 2018 | 1,622 |
| 30 | The Ventriloquist Effect Results from Near-Optimal Bimodal Integration | Current Biology | 2004 | 1,561 |
| 31 | Microbial diversity and soil functions | European Journal of Soil Science | 2003 | 1,538 |
| 32 | Magnetism of Lanthanides in Molecular Materials with Transition-Metal Ions and Organic Radicals | Chemical Reviews | 2002 | 1,519 |
| 33 | The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1 | Epilepsia | 2011 | 1,491 |
| 34 | Randomized Trial of the Effects of Risedronate on Vertebral Fractures in Women with Established Postmenopausal Osteoporosis | Osteoporosis International | 2000 | 1,472 |
| 35 | Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution | Journal of Molecular Medicine | 2003 | 1,467 |
| 36 | TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system | Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin | 2006 | 1,418 |
| 37 | Quantum Phase Interference and Parity Effects in Magnetic Molecular Clusters | Science | 1999 | 1,395 |
| 38 | Interfering with pH regulation in tumours as a therapeutic strategy | Nature Reviews Drug Discovery | 2011 | 1,372 |
| 39 | Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis | American Journal of Clinical Nutrition | 2010 | 1,344 |
| 40 | Cholangiocarcinoma 2020: the next horizon in mechanisms and management | Nature Reviews Gastroenterology and Hepatology | 2020 | 1,321 |
| 41 | Lymphokine Production by Human T Cells in Disease States | Annual Review of Immunology | 1994 | 1,319 |
| 42 | Guidelines for the Management of Asymptomatic Primary Hyperparathyroidism: Summary Statement from the Fourth International Workshop | Journal of Clinical Endocrinology and Metabolism | 2014 | 1,302 |
| 43 | Adherence to Mediterranean diet and health status: meta-analysis | BMJ: British Medical Journal | 2008 | 1,295 |
| 44 | Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC) | Blood | 2007 | 1,278 |
| 45 | Role for Interferon-γ in the Immunomodulatory Activity of Human Bone Marrow Mesenchymal Stem Cells | Stem Cells | 2006 | 1,240 |
| 46 | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 | Nature Genetics | 2011 | 1,224 |
| 47 | Clinical Practice Guidelines for Multiple Endocrine Neoplasia Type 1 (MEN1) | Journal of Clinical Endocrinology and Metabolism | 2012 | 1,174 |
| 48 | Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians | PLoS ONE | 2010 | 1,157 |
| 49 | New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment | Blood | 2009 | 1,125 |
| 50 | Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture | Nature Genetics | 2012 | 1,120 |
